全文获取类型
收费全文 | 1278425篇 |
免费 | 98043篇 |
国内免费 | 1989篇 |
专业分类
耳鼻咽喉 | 18423篇 |
儿科学 | 44349篇 |
妇产科学 | 35008篇 |
基础医学 | 182163篇 |
口腔科学 | 33585篇 |
临床医学 | 111244篇 |
内科学 | 258207篇 |
皮肤病学 | 28020篇 |
神经病学 | 100356篇 |
特种医学 | 51198篇 |
外国民族医学 | 660篇 |
外科学 | 196374篇 |
综合类 | 27048篇 |
现状与发展 | 1篇 |
一般理论 | 377篇 |
预防医学 | 95713篇 |
眼科学 | 27912篇 |
药学 | 94761篇 |
2篇 | |
中国医学 | 2422篇 |
肿瘤学 | 70634篇 |
出版年
2018年 | 13131篇 |
2017年 | 9962篇 |
2016年 | 10896篇 |
2015年 | 12369篇 |
2014年 | 17162篇 |
2013年 | 26208篇 |
2012年 | 36018篇 |
2011年 | 38050篇 |
2010年 | 22799篇 |
2009年 | 21806篇 |
2008年 | 36633篇 |
2007年 | 39243篇 |
2006年 | 39498篇 |
2005年 | 38439篇 |
2004年 | 37589篇 |
2003年 | 36443篇 |
2002年 | 35793篇 |
2001年 | 63987篇 |
2000年 | 66494篇 |
1999年 | 56407篇 |
1998年 | 15128篇 |
1997年 | 13753篇 |
1996年 | 14195篇 |
1995年 | 13452篇 |
1994年 | 12765篇 |
1993年 | 11790篇 |
1992年 | 44554篇 |
1991年 | 43464篇 |
1990年 | 42216篇 |
1989年 | 40111篇 |
1988年 | 36894篇 |
1987年 | 36234篇 |
1986年 | 33618篇 |
1985年 | 32278篇 |
1984年 | 24136篇 |
1983年 | 20268篇 |
1982年 | 11723篇 |
1981年 | 10691篇 |
1980年 | 9515篇 |
1979年 | 21341篇 |
1978年 | 14821篇 |
1977年 | 12532篇 |
1976年 | 11693篇 |
1975年 | 12623篇 |
1974年 | 14661篇 |
1973年 | 14117篇 |
1972年 | 12944篇 |
1971年 | 11729篇 |
1970年 | 11050篇 |
1969年 | 10024篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
171.
In experiments on albino rats it was established that three administrations of indomethacin in a dose of 0.01 g/kg body weight induced a severe damage of the liver characterized by disturbances of hepatocytic membranes, bile-producing and protein-producing functions of the liver, an enhancement of lipid peroxidation, a decrease of reduced glutathione pool. Antioxidants (tocopherol acetate, essentiale, legalon, flacumin) limit manifestations of indomethacin, hepatotoxicity, as a result of which tha functional-biochemical disorders in the liver show up to a lesser degree. During the combined use of antioxidants in indomethacin-induced lesions of the liver their hepatoprotective activity increases. 相似文献
172.
J Combe P Poinsard J Besancenot G Camelot F Cattin J F Bonneville T Moulin J L Henlin J L Chopard L Cotte 《Annals of vascular surgery》1990,4(6):558-562
Free-floating clots of the extracranial internal carotid artery are generally considered as surgical emergencies. This retrospective study analyzes six free-floating clots diagnosed by arteriography. Three of these patients had a fixed stroke while the other three had an evolving stroke. Three patients had antecedent ocular or hemispheric transient ischemic attacks. The causes of free-floating clots in the internal carotid artery were atheromatous stenosis in two cases, ulcerated plaque in three cases, and carotid artery dissection in one. All six patients were seen late, approximately 15 hours after their neurologic accident. They were treated with intravenous heparin over a two to five week period. Repeat arteriograms demonstrated complete clot lysis in four instances, while partial lysis was seen in one case. Moderate extension of thrombus occurred in one case only. No further neurologic complications were noted during the treatment by heparin. As indicated by follow-up arteriographic findings, secondary surgery was performed for major carotid lesions and residual clots in five cases. The free-floating thrombus syndrome of the carotid artery should not be considered as a surgical emergency when discovered late in the wake of an acute neurologic accident. 相似文献
173.
Facilitated uptake of zinc into human erythrocytes. Relevance to the treatment of sickle-cell anaemia 总被引:1,自引:0,他引:1
R C Hider L Ejim P D Taylor R Gale E Huehns J B Porter 《Biochemical pharmacology》1990,39(6):1005-1012
The ability of a number of heterocyclic metal chelators to deliver zinc into red cells, to release the liganded zinc to haemoglobin and thereby cause a left shift in the oxygen dissociation curve of intact red cells has been investigated. Incubation of neutrally charged zinc-pyrone and zinc-pyridin-2-one complexes with red cells led to the rapid accumulation of zinc within cells, whereas unliganded zinc in the form of zinc acetate, zinc chloride or zinc sulphate accumulated only slowly. The rate at which zinc was delivered to red cells by pyrone and pyridin-2-one ligands increased with increasing lipid solubility of the ligands. The uptake of zinc into both normal adult and sickle red cells was associated with a dose-dependent increase in the oxygen affinity of haemoglobin. The degree of left shift in the oxygen dissociation curve following the incubation of red cells with zinc-pyrone and -pyridin-2-one complexes suggests that these complexes may find application as agents to increase the oxygen affinity of haemoglobin in sickle cell disease and thereby decrease the probability of intravascular sickling at low tissue oxygen tensions. Ethylmaltol appears to be a particularly useful agent due to its known low toxicity. 相似文献
174.
We treated 100 consecutive ureteral calculi requiring intervention with a previously described algorithm. There were 16 ureteropelvic junction, and 18 upper, 22 mid and 44 lower ureteral calculi. Treatment was by a stent and extracorporeal shock wave lithotripsy in 10 ureteropelvic junction, 10 upper ureteral and 3 mid ureteral calculi, ureteroscopy and extracorporeal shock wave lithotripsy in 6 upper and 6 mid ureteral calculi, and ureteroscopy alone in 5 ureteropelvic junction, 2 upper and 12 mid ureteral calculi. All 44 lower ureteral calculi were treated successfully by ureteroscopy. Of the 100 patients studied 98 were treated by endourological methods (extracorporeal shock wave lithotripsy or ureteroscopy), while 2 required an operation (1 with a ureteropelvic junction calculus and 1 with a mid ureteral calculus). Over-all, 100 patients required a total of 125 procedures to accomplish successful stone removal. An algorithm is developed in which lower ureteral calculi are treated by ureteroscopy, mid ureteral calculi (large and dense) by stent bypass and extracorporeal shock wave lithotripsy or (lucent and fragile) by ureteroscopy, upper ureteral calculi by stent bypass and extracorporeal shock wave lithotripsy without manipulation, and impacted ureteral stones initially by ureteroscopy and, if necessary, then by extracorporeal shock wave lithotripsy. 相似文献
175.
We report a case of left iliofemoral vein thrombosis with extension to the inferior vena cava associated with giant right hydronephrosis secondary to ureteropelvic junction obstruction. Surgery revealed marked infrarenal vena caval compression and deviation to the left side caused by the dilated right renal pelvis, with resultant kinking of the origin of the left iliac vein. It is postulated that the reduction in blood flow caused by this compression and distortion predisposed this patient to venous thrombosis. 相似文献
176.
The amount of endothelial cell loss that occurs to the donor cornea during the trephination process was evaluated in 40 porcine eyes. A vital staining technique (alizarin red S and acid violet 19) was used to quantify the extent of endothelial damage and removal. Two types of corneal punches (Weck and H&I0 were used for trephination. The average amount of endothelial loss from the peripheral cornea was 7.9%, accounting for only a 3% loss of endothelial cells over the total surface area of the corneal button. a comparison of the Weck and H&I corneal punches showed no significant difference (P greater than 0.1) by Student's test for both endothelial cell damage and removal. 相似文献
177.
178.
G Durrieu P Valet M Berlan A Villeneuve J L Montastruc 《European journal of pharmacology》1990,182(3):597-601
Treatment of dogs for 21 days with oral levodopa (100 mg b.i.d.) plus benserazide (25 mg b.i.d.) induced a significant increase in the number of platelet alpha 2-adrenoceptors labelled by [3H] yohimbine with no change in Kd. The rise was maximal at the end of the treatment and remained significant during the month following the cessation of treatment. Plasma catecholamine levels did not vary. Competition experiments showed a low affinity of both dopamine and levodopa for platelet alpha 2-adrenoceptors. These results suggest that levodopa treatment regulates alpha 2-adrenoceptor number in dog platelets. 相似文献
179.
J Rochemaure P Lehert J Sauvaget M Robillard A Betbeder-Matibet 《Revue de pneumologie clinique》1988,44(1):43-47
Fifty-six patients with recurrent bronchopulmonary infections associated with chronic bronchitis were randomly allocated to 2 groups, to assess whether treatment with an immunomodulator, Diribiotin CK, could enhance resistance to infection. The double-blind, placebo-controlled prospective trial over a 9 month period showed that this immunomodulator was well tolerated and significantly reduced the rate of respiratory tract infection. The drug also significantly reduced the prescribing of antibiotic medication and the rate of absenteism from work. These effects have been demonstrated in a rigorously designed clinical study. This is the first time that a clear clinical activity has been attributed to an inducer of soluble mediators of immunity. 相似文献
180.
A. Taytard J. F. Tessier J. G. Faugere J. Vergeret P. Freour 《European journal of epidemiology》1988,4(3):326-330
Professional exposure to vegetable dusts affect the respiratory function of the exposed subjects. A previous survey conducted in an industrial flour-mill demonstrated a higher frequency of respiratory symptoms in workers compared to a control group. Ten subjects employed in a work site particularly exposed to dust were studied. Each subject answered a questionnaire and performed on Mondays and Fridays, at the begenning and end of his work shift, a flow volume curve and an isocapnic hyperventilation test. The aerobiology of the professional environment was also measured. We noted: 1) in the flow volume curves: a drop in the FEV1 during the Monday morning shift, a significant difference between the FEV1 (p<0.05) and the MMEFR 25–75 (p<0.05) measured at 6 am on Monday and Friday, and between the MMEFR 25–75 values obtained at 12 noon on Monday and Friday (p<0.05). 2) after isocapnic hyperventilation, a significant drop in the MMEFR 25–75 at 6 am on Monday (p<0.01) and in the FEV1 and MMEFR 25–75 at 12 noon on Mondays (p<0.05), a significant drop in the FEV1 at 1 pm on Monday (p<0.01). 相似文献