全文获取类型
收费全文 | 640篇 |
免费 | 38篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 28篇 |
妇产科学 | 7篇 |
基础医学 | 46篇 |
口腔科学 | 26篇 |
临床医学 | 141篇 |
内科学 | 143篇 |
皮肤病学 | 2篇 |
神经病学 | 8篇 |
特种医学 | 157篇 |
外科学 | 33篇 |
综合类 | 24篇 |
预防医学 | 25篇 |
药学 | 23篇 |
肿瘤学 | 33篇 |
出版年
2023年 | 6篇 |
2022年 | 3篇 |
2021年 | 10篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 5篇 |
2017年 | 6篇 |
2016年 | 9篇 |
2015年 | 5篇 |
2014年 | 15篇 |
2013年 | 24篇 |
2012年 | 10篇 |
2011年 | 16篇 |
2010年 | 23篇 |
2009年 | 44篇 |
2008年 | 15篇 |
2007年 | 15篇 |
2006年 | 8篇 |
2005年 | 14篇 |
2004年 | 4篇 |
2003年 | 10篇 |
2002年 | 11篇 |
2001年 | 12篇 |
2000年 | 14篇 |
1999年 | 10篇 |
1998年 | 40篇 |
1997年 | 38篇 |
1996年 | 37篇 |
1995年 | 35篇 |
1994年 | 22篇 |
1993年 | 25篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 8篇 |
1989年 | 25篇 |
1988年 | 24篇 |
1987年 | 15篇 |
1986年 | 11篇 |
1985年 | 17篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 19篇 |
1981年 | 12篇 |
1980年 | 17篇 |
1979年 | 1篇 |
1978年 | 8篇 |
1977年 | 11篇 |
1976年 | 7篇 |
1975年 | 2篇 |
排序方式: 共有698条查询结果,搜索用时 0 毫秒
601.
602.
603.
Platelet adhesion to an injured blood vessel wall is a critical initiating step in hemostasis mediated by a four member receptor complex (glycoprotein Ib/V/IX) interacting with plasma von Willebrand factor (vWF). The function of the GPV subunit within this complex is presently undefined. To study the role of glycoprotein (GP) V within the GPIb receptor complex, we transfected the GPV subunit gene into a hematopoietic cell line that constitutively expresses the other three subunits (human erythroleukemia [HEL] cells). Using flow cytometry, we found transfected GPV was surface expressed in HEL cells; this, in turn, led to increased surface expression of the ligand-binding GPIb alpha and GPIX subunits. Radioligand binding assays showed that GPV- transfected HEL cells bound more vWF than their non- or mock- transfected counterparts. We employed confocal microscopy of GPV- transfected HEL cells to show that GPV colocalizes with GPIb alpha on the cell surface. These findings suggest that the GPV subunit plays a role within the GPIb receptor complex by enhancing Ib alpha surface expression. 相似文献
604.
Del (7)(q32) is associated with a subset of small lymphocytic lymphoma with plasmacytoid features 总被引:1,自引:0,他引:1
Deletions of the long arm of chromosome 7, previously documented in myelodysplasias and myeloid leukemias, have also been noted in lymphoid malignancies. Of 558 karyotypically abnormal specimens of non-Hodgkin's lymphoma (NHL) serially ascertained over an 8-year period, del(7q) was identified in 24 cases, 10 of which were of the small lymphocytic (sm lym) subtype. Del(7q) was the third most common karyotypic abnormality among the cohort of 61 sm lym cases in this ascertainment. Mapping of the deletions identified a region of common deletion affecting 7q32, which was the sole karyotypic abnormality in 2 cases. Eight of the ten sm lym cases were characterized by plasmacytoid features in histologic sections of lymphoma tumors or circulating cells in the peripheral blood. The del(7)(q32) was accompanied by 14q32-associated translocations in 11 of the 14 cases with histologies other than sm lym, compared with 2 of the sm lym cases. Extranodal involvement was more frequent in the del(7)(q32) sm lym NHLs, although median survival was typical of other low-grade lymphomas. These results suggest that loss or inactivation of a putative tumor-supressor gene at 7q32 may play a role the progression of lymphomas as well as constitute an early event in the pathogenesis of lymphoplasmacytoid tumors. 相似文献
605.
606.
Experimental Pseudomonas pneumonia in leukopenic dogs: comparison of therapy with antibiotics and granulocyte transfusions 总被引:2,自引:0,他引:2
Pseudomonas aeruginosa pneumonia was produced in dogs with radiation- induced leukopenia to study the comparative efficacy of several different therapies. In a randomized control trial, five treatment regimens were compared: no antibiotics or granulocytes (controls), gentamicin (5 mg/kg/day), carbenicillin (500 mg/kg/day), gentamicin and carbenicillin (same dosages), and daily granulocyte transfusion (minimum 5 x 10(9) cells/day) plus gentamicin (5 mg/kg/day). The most effective therapy was gentamicin plus granulocyte transfusions. Gentamicin alone was not significantly better than no specific therapy. Carbenicillin with or without gentamicin gave intermediate results. This study further supports the utility of granulocyte replacement therapy of infections in severely granulocytopenic subjects. The results also indicate that the relative value of granulocyte transfusions depends upon the specific antibiotic regimen with which these transfusions are compared. 相似文献
607.
608.
609.
610.