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991.
Fowler JC Solanki CK Barber RW Ballinger JR Peters AM 《Acta oncologica (Stockholm, Sweden)》2007,46(1):105-110
The aim of this study was to develop and evaluate 111In- and 99mTc-labeled derivatives of albumin nanocolloid (NC) for dual-label lymphoscintigraphy to allow simultaneous comparison of lymphatic flow from different tissue planes draining a tumour bed for accurate identification of sentinel lymph nodes (SLN). Using the chelator, p-isothiocyanatobenzyl-1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid (DOTA), 111In-DOTA-NC and 99mTc-DOTA-NC were compared in vitro with respect to stability of labeling, colloidal status and particle size, then in vivo by measuring their clearance rates from a subcutaneous injection depot. 111In-DOTA-NC and 99mTc-DOTA-NC were indistinguishable on the basis of in vitro criteria. Their in vivo clearance rates, however, were disparate (0.0015 to 0.075 min-1 for 111In and 0.0072 to 0.067 min-1 for 99mTc), 111In being faster in three studies and markedly slower in three. This demonstrates that even when dual-labeled radiotracers behave identically in vitro, they will not necessarily do so in vivo. Further work is needed to develop dual-labeled NC. 相似文献
992.
Hemendra Pratap Singh S. N. Pandeya C. S. Chauhan Chandra Shekhar Sharma 《Medicinal chemistry research》2011,20(1):74-80
In the present study, we have synthesized chalcone and semicarbazide-linked chalonyl derivatives and the titled compounds
confirmed by MS, IR, and 1H NMR techniques. The anticonvulsant activity was determined by maximal electroshock (MES) induced seizure method. A majority
of the compounds exhibited significant anticonvulsant activity after intraperitoneal administration. The results show the
importance of hydrogen bonding for activity. In the present study 5e, 5h, 5i, 6e, 6h, and 6i emerged as the most active molecules, showed significant anticonvulsant of activity. 相似文献
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BACKGROUND: Brainstem gliomas are highly heterogeneous tumors both in their clinical manifestation and in their pathology. Despite significant advances in the surgery for brainstem gliomas many aspects of this pathology are still unelear. OBJECTIVE: To evaluate the clinical, radiological and surgical outcome of 40 focal "intrinsic" brainstem gliomas and propose a surgical strategyoriented classification. MATERIALS AND METHODS: A total of 40 focal ‘intrinsie’ ("expanding variety") tumors have been operated over a period of 8.5-years (January 1998-June 2007). Our criteria included patients with (1) well-defined gadolinium enhancing tumor, (2) relatively long duration of symptoms (〉 six months) and (3) good neurological functional status and independent for all activities of davy living. The cutoff size of 2 cm was not rigidly adhered to. RESULTS: The "intrinsic" brainstem tumors were classified into three types: Expanding, diffuse infiltrative and pure ventral varieties. 相似文献
996.
Anjali Gupta Anshu Gupta Sonal Gupta Asha Mittal Phool Chandra Amarjit K. Gill 《Archives of gynecology and obstetrics》2009,280(6):981-985
Background
The role of genital mycoplasmas, particularly Ureaplasma urealyticum, in the etiology of infertility has been very controversial. An attempt has been made to explore the role of mycoplasma in unexplained infertility. 相似文献997.
Chander Shekhar Gautam Amita Utreja Divya Goel Gurpreet Sandhu Nidhi Gogia 《Indian journal of gastroenterology》2009,28(4):147-149
Proton pump inhibitors (PPIs) have been known to cause bradycardia. We evaluated the effect of three PPIs, i.e. omeprazole,
rabeprazole and pantoprazole on the heart rate of frog. The in situ frog heart preparation was set up. Heart rate and amplitude of contraction were studied following administration of different
doses of the three PPIs. Statistical analysis was done by using Graphpad statistical software system. After 1 mg of omeprazole
and rabeprazole, and 2 mg pantoprazole, the heart rate was similar as compared to baseline (p >0.05). After 2 mg of omeprazole
and rabeprazole, and 4 mg pantoprazole, the reduction in heart rate was significant (p <0.05). In addition, pantoprazole caused
negative ionotropic effect. The three PPIs showed a dose-dependent negative chronotropic effect in the frog heart prepration. 相似文献
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999.
Gouri Sankar Bhunia Manas Ranjan Dikhit Shreekant Kesari Ganesh Chandra Sahoo Pradeep Das 《生物医学研究杂志》2012,26(5):371
The author would like to inform the readers that the correct form of title "Role of remote sensing, geographic bioinformatics system and bioinformatics in kala-azar epidemiology",content in abstract "The computational approaches like remote sensing,geographic information system(GIS) and 相似文献
1000.
To develop a grading system for retinitis pigmentosa (RP), providing clinicians with a simple, objective measure of disease severity. An observational case series of 14 patients with RP. Disease severity was assessed using four criteria; clinical appearance, visual acuity (best corrected LogMAR, BCVA), perimetry (mean deviation, MD) and Fourier-domain optical coherence tomography (outer retinal thickness, ORT at the fovea). Each criterion was scored on a severity scale from 0 (mild disease) to 4 (severe disease), giving an overall score out of 16. The mean BCVA was 0.37 LogMAR (range 0.02 to PL), mean MD was ?25.35 dB (range ?7.48 to ?34.38 dB), mean retinal thickness at the fovea was 189.4 μm (range 96.5?264.5 μm) and mean ORT at the fovea was 140.6 μm (range 63.4?193.4 μm). The clinical appearance correlated well with each of the quantitative measures of disease severity; BCVA (0.62, p = 0.022), MD (?0.903, p < 0.0001) and ORT (?0.698, p = 0.005). Applying the grading system to our patients, the severity scores were evenly spread between grades 1 and 14. We present a simple, objective grading system for RP offering a potential tool for grading disease severity with applications such as assessing progression, comparing patient populations and measuring outcomes in clinical trials. 相似文献