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731.
José Alcides A de Arruda Lauren F Schuch Lucas G Abreu Leni Verônica O Silva João Luiz GC Monteiro Rodrigo FC Pinho Leorik P Silva Suzana COM de Sousa Bruno Augusto B de Andrade Mario José Romañach Simone de QC Lourenço Aline C Batista Elismauro Francisco de Mendonça Manoela D Martins Pantelis V Rados Elena RC Rivero Lélia B de Souza Maria das GR Pinheiro Ana Paula N Gomes Ana Carolina U Vasconcelos Ana Paula V Sobral Ricardo A Mesquita 《Oral diseases》2018,24(7):1282-1293
732.
Shalhoub V Shatzen EM Ward SC Davis J Stevens J Bi V Renshaw L Hawkins N Wang W Chen C Tsai MM Cattley RC Wronski TJ Xia X Li X Henley C Eschenberg M Richards WG 《The Journal of clinical investigation》2012,122(7):2543-2553
Chronic kidney disease-mineral and bone disorder (CKD-MBD) is associated with secondary hyperparathyroidism (HPT) and serum elevations in the phosphaturic hormone FGF23, which may be maladaptive and lead to increased morbidity and mortality. To determine the role of FGF23 in the pathogenesis of CKD-MBD and development of secondary HPT, we developed a monoclonal FGF23 antibody to evaluate the impact of chronic FGF23 neutralization on CKD-MBD, secondary HPT, and associated comorbidities in a rat model of CKD-MBD. CKD-MBD rats fed a high-phosphate diet were treated with low or high doses of FGF23-Ab or an isotype control antibody. Neutralization of FGF23 led to sustained reductions in secondary HPT, including decreased parathyroid hormone, increased vitamin D, increased serum calcium, and normalization of bone markers such as cancellous bone volume, trabecular number, osteoblast surface, osteoid surface, and bone-formation rate. In addition, we observed dose-dependent increases in serum phosphate and aortic calcification associated with increased risk of mortality in CKD-MBD rats treated with FGF23-Ab. Thus, mineral disturbances caused by neutralization of FGF23 limited the efficacy of FGF23-Ab and likely contributed to the increased mortality observed in this CKD-MBD rat model. 相似文献
733.
Surbhi Sidana Jugal Kishore Vidya Ghosh Divyansh Gulati RC Jiloha Tanu Anand 《The Australasian medical journal》2012,5(5):247-250
Background
Medical education is associated with various pressures and stresses which can lead to depression. This study was undertaken to discover the prevalence of depression in medical students and various factors contributing to depression.Method
This is a cross-sectional, questionnaire-based study. Using stratified random sampling, 237 students were selected according to year of study. Patient Health Questionnaire (PHQ-9), based on PRIME-MD Today, was used to make a provisional diagnosis of depression.Results
The overall prevalence of provisionally diagnosed depressive and major depressive disorder using PHQ-9 was 21.5% and 7.6%, respectively. Year of study and academic performance of students had a statistically significant association with depression. Other factors, including gender, self-reported past history of depression, family history of psychiatric disorders, type of social support, family structure, number of siblings and education of parents were not found to have any significant association with prevalence of depression in the study. It was also observed that students were reluctant to seek help for depressive symptoms. 相似文献734.
735.
CR de Andrade PF Leite AC Montezano DA Casolari A Yogi RC Tostes R Haddad MN Eberlin FRM Laurindo HP de Souza FMA Corr��a AM de Oliveira 《British journal of pharmacology》2009,157(4):568-580