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Sousa Pedro A. Barra Sérgio Puga Luís Sousa Catarina Elvas Luís 《Journal of interventional cardiac electrophysiology》2022,63(2):431-440
Journal of Interventional Cardiac Electrophysiology - The purpose of the study was to investigate the usefulness of the extended early meets late (EEML) feature of the HD Coloring software for... 相似文献
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Catarina Addobbati Lucas André Cavalcanti Brandão Rafael Lima Guimarães João Alexandre Trés Pancotto Eduardo Antônio Donadi Sergio Crovella Ludovica Segat Paula Sandrin-Garcia 《Human immunology》2013
Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease affecting different organs or systems. Several genes have been associated with SLE susceptibility so far. A previous study has reported, in SLE patients, a differential expression of Fyn Binding Protein gene (FYB), encoding for a protein participating in the T cells signaling cascade and in the interleukin-2A expression modulation. 相似文献
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Laura Cerqueira Ricardo M. Fernandes Rui M. Ferreira Mónica Oleastro Fátima Carneiro Catarina Brand?o Pedro Pimentel-Nunes Mário Dinis-Ribeiro Céu Figueiredo Charles W. Keevil Maria J. Vieira Nuno F. Azevedo 《Journal of clinical microbiology》2013,51(6):1887-1893
Here, we evaluated a previously established peptide nucleic acid-fluorescence in situ hybridization (PNA-FISH) method as a new diagnostic test for Helicobacter pylori clarithromycin resistance detection in paraffin-embedded gastric biopsy specimens. Both a retrospective study and a prospective cohort study were conducted to evaluate the specificity and sensitivity of a PNA-FISH method to determine H. pylori clarithromycin resistance. In the retrospective study (n = 30 patients), full agreement between PNA-FISH and PCR-sequencing was observed. Compared to the reference method (culture followed by Etest), the specificity and sensitivity of PNA-FISH were 90.9% (95% confidence interval [CI], 57.1% to 99.5%) and 84.2% (95% CI, 59.5% to 95.8%), respectively. In the prospective cohort (n = 93 patients), 21 cases were positive by culture. For the patients harboring clarithromycin-resistant H. pylori, the method showed sensitivity of 80.0% (95% CI, 29.9% to 98.9%) and specificity of 93.8% (95% CI, 67.7% to 99.7%). These values likely represent underestimations, as some of the discrepant results corresponded to patients infected by more than one strain. PNA-FISH appears to be a simple, quick, and accurate method for detecting H. pylori clarithromycin resistance in paraffin-embedded biopsy specimens. It is also the only one of the methods assessed here that allows direct and specific visualization of this microorganism within the biopsy specimens, a characteristic that allowed the observation that cells of different H. pylori strains can subsist in very close proximity in the stomach. 相似文献
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Edênia C. Menezes Relish Shah Lindsay Laughlin K. Yaragudri Vinod John F. Smiley Catarina Cunha Andrea Balla Henry Sershen Francisco X. Castellanos Andr Corvelo Ctia M. Teixeira 《The Journal of neuroscience》2021,41(12):2723
Early life is a sensitive period, in which enhanced neural plasticity allows the developing brain to adapt to its environment. This plasticity can also be a risk factor in which maladaptive development can lead to long-lasting behavioral deficits. Here, we test how early-life exposure to the selective-serotonin-reuptake-inhibitor (SSRI), fluoxetine, affects motivation, and dopaminergic signaling in adulthood. We show for the first time that mice exposed to fluoxetine in the early postnatal period exhibit a reduction in effort-related motivation. These mice also show blunted responses to amphetamine and reduced dopaminergic activation in a sucrose reward task. Interestingly, we find that the reduction in motivation can be rescued in the adult by administering bupropion, a dopamine-norepinephrine reuptake inhibitor used as an antidepressant and a smoke cessation aid but not by fluoxetine. Taken together, our studies highlight the effects of early postnatal exposure of fluoxetine on motivation and demonstrate the involvement of the dopaminergic system in this process.SIGNIFICANCE STATEMENT The developmental period is characterized by enhanced plasticity. During this period, environmental factors have the potential to lead to enduring behavioral changes. Here, we show that exposure to the SSRI fluoxetine during a restricted period in early life leads to a reduction in adult motivation. We further show that this reduction is associated with decreased dopaminergic responsivity. Finally, we show that motivational deficits induced by early-life fluoxetine exposure can be rescued by adult administration of bupropion but not by fluoxetine. 相似文献
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Wei Huang Robert J. Goldberg Frederick A. Anderson Catarina I. Kiefe Frederick A. Spencer 《The American journal of medicine》2014