全文获取类型
收费全文 | 440篇 |
免费 | 20篇 |
国内免费 | 9篇 |
专业分类
儿科学 | 20篇 |
妇产科学 | 5篇 |
基础医学 | 33篇 |
口腔科学 | 14篇 |
临床医学 | 48篇 |
内科学 | 118篇 |
皮肤病学 | 9篇 |
神经病学 | 8篇 |
特种医学 | 99篇 |
外科学 | 28篇 |
综合类 | 30篇 |
预防医学 | 13篇 |
眼科学 | 21篇 |
药学 | 2篇 |
肿瘤学 | 21篇 |
出版年
2023年 | 1篇 |
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 4篇 |
2018年 | 3篇 |
2017年 | 5篇 |
2016年 | 2篇 |
2015年 | 9篇 |
2014年 | 5篇 |
2013年 | 9篇 |
2012年 | 3篇 |
2011年 | 8篇 |
2010年 | 20篇 |
2009年 | 17篇 |
2008年 | 5篇 |
2007年 | 19篇 |
2006年 | 14篇 |
2005年 | 4篇 |
2004年 | 14篇 |
2003年 | 2篇 |
2002年 | 3篇 |
2001年 | 8篇 |
2000年 | 3篇 |
1999年 | 8篇 |
1998年 | 26篇 |
1997年 | 25篇 |
1996年 | 36篇 |
1995年 | 19篇 |
1994年 | 14篇 |
1993年 | 19篇 |
1992年 | 3篇 |
1991年 | 5篇 |
1990年 | 9篇 |
1989年 | 11篇 |
1988年 | 17篇 |
1987年 | 13篇 |
1986年 | 14篇 |
1985年 | 10篇 |
1984年 | 9篇 |
1983年 | 12篇 |
1982年 | 7篇 |
1981年 | 13篇 |
1980年 | 7篇 |
1979年 | 1篇 |
1978年 | 5篇 |
1977年 | 7篇 |
1976年 | 7篇 |
1975年 | 4篇 |
1973年 | 2篇 |
1972年 | 1篇 |
排序方式: 共有469条查询结果,搜索用时 31 毫秒
71.
72.
73.
74.
Fanconi anemia is an autosomal recessive disease characterized by a high risk of developing bone marrow (BM) failure and acute myelogenous leukemia. We studied growth of hematopoietic progenitor cells in long- term BM culture (LTBMC) in 8 persons with Fanconi anemia and BM failure. Although LTBMC were initiated with very few BM cells, an adherent layer formed in cultures from 7 persons. In these cultures, the number of nonadherent cells increased for 10 to 15 days. Cell growth continued until cultures were terminated at day 35 to 40. During the first 2 weeks of culture, most nonadherent cells were differentiated myeloid cells. By days 35 to 40, the adherent layer contained cells able to initiate secondary LTBMCs. These data indicate that hematopoietic precursors cells able to proliferate and differentiate in vitro are present in the BM of persons with Fanconi anemia and BM failure. They suggest that mechanisms other than absent precursor cells are responsible for BM failure in Fanconi anemia. 相似文献
75.
76.
77.
78.
Introduction: A heavier weight in adults is becoming the norm rather than an abnormal weight. Whether the same trend is happening in children is unknown. Objective: To assess the perception of the weight of 4‐ to 5‐year‐old children and the recognition of overweight by both parents. Design: Population‐based survey. Participants: A questionnaire was sent to parents of 1155 4‐ to 5‐year‐old children. Results: In total, 439 questionnaires (35%) were returned. Of all, 90% of the children had a normal weight, 9.3% were overweight and 4.1% were obese. For all weight classes, the parents depicted the child as lighter on both the verbal and visual scale. Of all, 75% of mothers of overweight children stated that the child had a normal weight. In obese children, 50% of the mothers believed that the child had a normal weight. Conclusion: Children with a weight in the normal range were considered by their parents as a little too light or too light. Overweight was considered as normal weight, and obesity as normal or a little too heavy. The perception of a normal weight in children at 4–5 years is distorted. 相似文献
79.
AJ Wearden L Riste C Dowrick C Chew-Graham RP Bentall RK Morriss S Peters G Dunn G Richardson K Lovell P Powell 《BMC medicine》2006,4(1):1-12
Background
A major change has occurred in the last few years in the therapeutic approach to patients presenting with all forms of acute coronary syndromes. Whether or not these patients present initially to tertiary cardiac care centers, they are now routinely referred for early coronary angiography and increasingly undergo percutaneous revascularization. This practice is driven primarily by the angiographic image and technical feasibility. Concomitantly, there has been a decline in expectant or ischemia-guided medical management based on specific clinical presentation, response to initial treatment, and results of noninvasive stratification. This 'tertiarization' of acute coronary care has been fuelled by the increasing sophistication of the cardiac armamentarium, the peer-reviewed publication of clinical studies purporting to show the superiority of invasive cardiac interventions, and predominantly supporting (non-peer-reviewed) editorials, newsletters, and opinion pieces.Discussion
This review presents another perspective, based on a critical reexamination of the evidence. The topics addressed are: reperfusion treatment of ST-elevation myocardial infarction; the indications for invasive intervention following thrombolysis; the role of invasive management in non-ST-elevation myocardial infarction and unstable angina; and cost-effectiveness and real world considerations. A few cases encountered in recent practice in community and tertiary hospitals are presented for illustrative purposes The numerous and far-reaching scientific, economic, and philosophical implications that are a consequence of this marked change in clinical practice as well as healthcare, decisional and conflict of interest issues are explored.Summary
The weight of evidence does not support the contemporary unfocused broad use of invasive interventional procedures across the spectrum of acute coronary clinical presentations. Excessive and unselective recourse to these procedures has deleterious implications for the organization of cardiac health care and undesirable economic, scientific and intellectual consequences. It is suggested that there is need for a new equilibrium based on more refined clinical risk stratification in the treatment of patients who present with acute coronary syndromes. 相似文献80.
RP Dayasena MBKC Dayasiri C Jayasuriya DSC Perera 《The Australasian medical journal》2011,4(2):101-104