全文获取类型
收费全文 | 5517篇 |
免费 | 409篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 44篇 |
儿科学 | 163篇 |
妇产科学 | 103篇 |
基础医学 | 932篇 |
口腔科学 | 68篇 |
临床医学 | 922篇 |
内科学 | 1072篇 |
皮肤病学 | 51篇 |
神经病学 | 490篇 |
特种医学 | 127篇 |
外科学 | 397篇 |
综合类 | 42篇 |
一般理论 | 8篇 |
预防医学 | 632篇 |
眼科学 | 85篇 |
药学 | 339篇 |
中国医学 | 10篇 |
肿瘤学 | 451篇 |
出版年
2023年 | 25篇 |
2022年 | 57篇 |
2021年 | 121篇 |
2020年 | 76篇 |
2019年 | 124篇 |
2018年 | 157篇 |
2017年 | 92篇 |
2016年 | 117篇 |
2015年 | 123篇 |
2014年 | 177篇 |
2013年 | 285篇 |
2012年 | 415篇 |
2011年 | 434篇 |
2010年 | 207篇 |
2009年 | 196篇 |
2008年 | 373篇 |
2007年 | 355篇 |
2006年 | 362篇 |
2005年 | 371篇 |
2004年 | 321篇 |
2003年 | 316篇 |
2002年 | 303篇 |
2001年 | 70篇 |
2000年 | 51篇 |
1999年 | 62篇 |
1998年 | 61篇 |
1997年 | 57篇 |
1996年 | 55篇 |
1995年 | 35篇 |
1994年 | 40篇 |
1993年 | 32篇 |
1992年 | 38篇 |
1991年 | 38篇 |
1990年 | 35篇 |
1989年 | 27篇 |
1988年 | 22篇 |
1987年 | 24篇 |
1986年 | 25篇 |
1985年 | 21篇 |
1984年 | 24篇 |
1983年 | 25篇 |
1982年 | 37篇 |
1981年 | 11篇 |
1980年 | 21篇 |
1979年 | 14篇 |
1977年 | 14篇 |
1976年 | 9篇 |
1974年 | 16篇 |
1973年 | 9篇 |
1968年 | 7篇 |
排序方式: 共有5936条查询结果,搜索用时 15 毫秒
81.
82.
Viviane Guerdan Cécile Belet Carole Corthesy Antoine Jaccottet Vincent Gigon 《ALTER. European Journal of Disability research, Journal europeen de recherche sur le handicap》2013,7(1):3-19
Within the framework of training offered by the University of Teacher Education of the State of Vaud leading to a Masters of Arts in Special Education and the Diploma in Special Education, four teachers in special education and a trainer-researcher undertook research work using the ICF-CY (WHO, 2007) for educational purposes. Focusing on the indicators of participation and environment, and operating on the hypothesis that these two types of variables are closely linked, they observed teaching situations in their respective workplaces. This study highlights the influence of environmental factors – one of which is the teacher – on pupil participation, and offers proposals for adjusting the terminology used by teachers in special education. The work is of particular relevance in that it opens up new observational perspectives that can, on the one hand, help to avoid the pitfall of focusing on a pupil's difficulties, delayed development, disabilities and/or limitations and, on the other hand, favor the work of identification of the educational actions to be undertaken. 相似文献
83.
ABSTRACT Aphasia often restricts participation. People living with aphasia (PLWA) engage in fewer activities, which leads to fewer interactions than before aphasia. Analyses of interactions with non-familiar people in activities of daily life could provide knowledge about how to integrate these situations in rehabilitation and facilitate ongoing PLWA participation post-rehabilitation. This qualitative study is the first to examine how PLWA make their requests understood in service encounters despite aphasia. Six people living with moderate or severe aphasia were video-recorded in situations of service encounters, e.g., pharmacies, specialised shops, restaurants, and others. We identified fifty-nine occurrences with one or several difficulties in the formulation of the request. They were examined, including the clerks’ responses and ensuing interaction using multimodal conversation analysis. Results showed that PLWA used nonverbal communication within the physical environment and the context of the interaction to support verbal production. In the majority of situations, the clerks understood the request promptly. In other situations, they both collaborated to achieve a clear understanding of the request. Moreover, the findings attest to the competence of people living with moderate or severe aphasia in engaging in service encounters and add to the knowledge base about interaction and social participation in aphasia. 相似文献
84.
Pavani K. Ram Dhiman Dutt Benjamin J. Silk Saumil Doshi Carole B. Rudra Jaynal Abedin Doli Goswami Alicia M. Fry W. Abdullah Brooks Stephen P. Luby Adam L. Cohen 《The American journal of tropical medicine and hygiene》2014,90(5):968-975
To inform interventions to reduce the high burden of pneumonia in urban settings such as Kamalapur, Bangladesh, we evaluated household air quality risk factors for radiographically confirmed pneumonia in children. In 2009–2010, we recruited children < 5 years of age with pneumonia and controls from a population-based surveillance for respiratory and febrile illnesses. Piped natural gas was used by 85% of 331 case and 91% of 663 control households. Crowding, a tin roof in the living space, low socioeconomic status, and male sex of the child were risk factors for pneumonia. The living space in case households was 28% less likely than in control households to be cross-ventilated. Particulate matter concentrations were not significantly associated with pneumonia. With increasing urbanization and supply of improved cooking fuels to urban areas, the high burden of respiratory illnesses in urban populations such as Kamalapur may be reduced by decreasing crowding and improving ventilation in living spaces. 相似文献
85.
86.
87.
88.
Ha T. Huynh Jeffrey H. Grubb Carole Vogler William S. Sly 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(42):17022-17027
Enzyme replacement therapy has been used successfully in many lysosomal storage diseases. However, correction of brain storage has been limited by the inability of infused enzyme to cross the blood–brain barrier (BBB). We recently reported that PerT-GUS, a form of β-glucuronidase (GUS) chemically modified to eliminate its uptake and clearance by carbohydrate-dependent receptors, crossed the BBB and cleared neuronal storage in an immunotolerant model of murine mucopolysaccharidosis (MPS) type VII. In this respect, the chemically modified enzyme was superior to native β-glucuronidase. Chemically modified enzyme was also delivered more effectively to heart, kidney, and muscle. However, liver and spleen, which express high levels of carbohydrate receptors, received nearly fourfold lower levels of PerT-GUS compared with native GUS. A recent report on PerT-treated sulfamidase in murine MPS IIIA confirmed enhanced delivery to other tissues but failed to observe clearance of storage in neurons. To confirm and extend our original observations, we compared the efficacy of 12 weekly i.v. infusions of PerT-GUS versus native GUS on (i) delivery of enzyme to brain; (ii) improvement in histopathology; and (iii) correction of secondary elevations of other lysosomal enzymes. Such correction is a recognized biomarker for correction of neuronal storage. PerT-GUS was superior to native GUS in all three categories. These results provide additional evidence that long-circulating enzyme, chemically modified to escape carbohydrate-mediated clearance, may offer advantages in treating MPS VII. The relevance of this approach to treat other lysosomal storage diseases that affect brain awaits confirmation. 相似文献
89.
Hélène Jacqmin-Gadda Annick Alperovitch Claire Montlahuc Daniel Commenges Karen Leffondre Carole Dufouil Alexis Elbaz Christophe Tzourio Joël Ménard Jean-François Dartigues Pierre Joly 《European journal of epidemiology》2013,28(6):493-502
Incidence of dementia increases sharply with age and, because of the increase in life expectancy, the number of dementia cases is expected to rise dramatically over time. Some studies suggest that controlling some modifiable risk factors for dementia like diabetes or hypertension could lower its incidence. However, as treating these vascular factors would also reduce mortality risk, the actual impact of such public-health intervention on dementia prevalence is not known. Accounting for the impact of dementia and risk factors on mortality, the aim of this work was (1) to compute projections of age- and-sex specific prevalence of dementia in France from 2010 to 2030, (2) to evaluate how public-health interventions targeting risk factors for dementia could change these projections. Age-and-sex specific incidence of dementia and mortality of demented subjects were estimated from the Paquid population-based cohort using a semi-parametric illness-death model. Future global mortality rates and population sizes were obtained from national demographic projections. Under the assumption that life expectancy will increase by 3.5 years for men and 2.8 years for women by 2030, the number of subjects with dementia was estimated to increase by about 75 % from 2010 to 2030 with a 200 % increase after 90 years of age. Therapeutic intervention on the whole population reducing high blood pressure prevalence would lead to a decrease in both dementia incidence rates and mortality and would have a modest impact on the number of dementia cases. On the other hand, a preventive dementia treatment targeting ApoE4 carriers would probably not improve survival and hence would decrease dementia prevalence by 15–25 %. 相似文献