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排序方式: 共有1153条查询结果,搜索用时 15 毫秒
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María Jesús Fernández Aceñero MD PhD Cristina Díaz del Arco CDdA MD Carme Dinarés CD MD PhD Tania Labiano TL MD Eva Tejerina ET MD PhD Mª José Bernabé MJ B MD Elena Forcen EF MD Melchor Saiz-Pardo MSP MD Pablo Pérez PP MD Maria D. Lozano MDL MD PhD 《Diagnostic cytopathology》2023,51(1):26-35
Lung carcinoma remains one of the most frequent and aggressive human neoplasms. Fortunately, in the last decades, the increasing knowledge of the molecular mechanisms leading to cancer development has allowed the use of targeted therapies with improvement of prognosis in many patients. Clinical management has also changed after the introduction of endobronchialultrasonographic bronchoscopy that allows a conservative staging of lung tumors, avoiding the need of mediastinoscopy for lymph node staging. Lung pathologists and cytopathologists are facing the challenge of giving the more comprehensive prognostic and predictive information with ever smaller tissue or cytological samples. The aim of this review is to summarize the molecular testing for non-small cell lung carcinoma and how pathologists can contribute to the patient's outcome with a conscious management of biological samples. 相似文献
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Lara Cobler Raquel Mejías-Luque Marta Garrido Manuel Pera Enric Badia-Garrido Carme de Bolós 《Virchows Archiv : an international journal of pathology》2013,463(4):497-507
Trefoil factor 1 (TFF1) is expressed in the normal superficial epithelium of the stomach and is implicated in the maintenance of gastric epithelial structure and function. During gastric carcinogenesis, in which pro-inflammatory cytokines play a crucial role, its expression level decreases suggesting a role as tumor suppressor factor. We have compared expression of TFF1 in gastric mucosa from cancer patients, in which several degrees of inflammatory infiltrate are present, with that in normal mucosa from non-cancer patients without infiltrating inflammatory cells. TFF1 is less expressed in the superficial gastric epithelium from cancer patients than in that from normal individuals in which the nuclear factor (NF)-κB pathway is not activated. We analyzed TFF1 expression in ex vivo samples of gastric mucosa from cancer patients, and in MKN45 gastric cancer cell line after exposure to proinflammatory cytokines interleukin (IL)-1β or tumor necrosis factor (TNF)-α, that activate the NF-κB pathway. We found that IL-1β and TNF-α activate the NF-κB pathway, as reflected in the nuclear expression of p65 and the activation of p-IκBα, and downregulate TFF1 expression after 1 or 2 h of exposure. Moreover, cells in the superficial gastric epithelium in ex vivo samples co-expressed TFF1/p65 at cellular level, whereas tumor cells did not. In summary, downregulation of TFF1 expression during gastric neoplastic transformation is associated with activation of the NF-κB pathway through IL-1β or TNF-α, but other regulatory mechanisms might also be involved. 相似文献
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Carme Auladell Pol Pérez-Sust Hans Supèr Eduardo Soriano 《Brain structure & function》2000,201(3):169-179
The initial ingrowth of corticothalamic and thalamocortical projections was examined in mice at embryonic and perinatal stages.
Fibers, in fixed brains, were labeled with the carbocyanine dye 1,1’-dioctadecyl-3,3,3’,3’-tetramethylindocarbocianine perchlorate
(DiI). By E13, the corticofugal fibers had entered the lowest intermediate zone through which they ran, turned over the corpus
striatum, and left the cortex. The fibers were arranged in scattered bundles throughout the corpus striatum. At E14 corticofugal
axons reached the internal capsule and at E14.5–E15 they established contact within the thalamus. Meanwhile, the thalamocortical
afferents reached the neocortex at E13. At this time fibers ran tangentially within the intermediate zone, immediately underneath
the cortical plate. By E14, the fibers had started to invade the subplate and, by E15, thalamocortical fibers had begun their
radial growth into the cortex. Such radial growth proceeded steadily, invading each cortical layer as it differentiated cytoarchitectonically
from the dense cortical plate. The first retrogradely labeled cells were detected at the cortical plate at E15. By the day
of birth (E20), thalamocortical fibers had formed a dense branching system within layers VI and V. Our observations indicate
that, in mice, the thalamic axons reach the cortex before corticothalamic projections enter the thalamic nuclei. Moreover,
the results suggest that the pathway followed by each fiber system is different. By DiI injections into the internal capsule
we have also determined that subplate cells are the first to send axons to the thalamus.
Accepted: 11 August 1999 相似文献
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Pregnancy planning allows women to better control their life trajectory and contributes to the future child’s health and development.
Many studies that have analyzed socioeconomic inequalities in unintended pregnancy only took into account those pregnancies
ending in births. Few of them that analyzed unintended pregnancy, including both induced abortion and births, and its socioeconomic
determinants, concluded that unintended pregnancy is more frequent in young, poor, or unmarried women. These inequalities
have been poorly studied in Europe, especially in the southern European context. The aim of the present study is to describe
socioeconomic inequalities in unintended pregnancy and in abortion decision in Barcelona, Spain. The major findings are that
unintended pregnancies accounted for 41% of total pregnancy and of these, 60% ended in abortion. From all pregnancies, the
proportion of induced abortion reached 25.6%. Compared to women with university studies, those with primary education uncompleted
had more unintended pregnancies (OR = 7.22). When facing an unintended pregnancy, women of lower socioeconomic position are
more likely to choose induced abortion, although this is not the case among young or single women. This study reveals deep
socioeconomic inequalities in unintended pregnancies and abortion decision in Barcelona, Spain, where the birth rate is very
low and the abortion rate is rising. Women in low socioeconomic positions have many more unintended pregnancies than better
educated women. Except for young or single women, the lower the socioeconomic position, the higher the proportion of women
who choose an induced abortion when facing an unintended pregnancy.
Font-Ribera, Pérez, Salvador, and Borrell are with the Health Information Service, Agency of Public Health of Barcelona, Barcelona,
Spain; Pérez and Borrell are with the University Pompeu Fabra, Barcelona, Spain; Pérez and Borrell are with the CIBER in Epìdemiology
and Public Health (CIBERESP), Barcelona, Spain; Pérez is with the Agency of Public Health of Barcelona, Barcelona, Spain. 相似文献
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人力资源开发在医院人事管理中的应用 总被引:2,自引:0,他引:2
通过对传统的人事管理与资源开发型现代化人事管理的比较,从人力资源规划、工作系统研究和人员系统研究等3方面具体阐述了人力资源开发的重要性,真正将人才作为一种资源,以“人为中心”,寻求“人”与“工作”相互适应的契合点,使“人”的发展与医院的发展人机地联系起来,突出了管理领域人性回归的思想,从而使人力资源管理理念有了更丰富的内涵。 相似文献