全文获取类型
收费全文 | 31875篇 |
免费 | 2127篇 |
国内免费 | 138篇 |
专业分类
耳鼻咽喉 | 423篇 |
儿科学 | 760篇 |
妇产科学 | 644篇 |
基础医学 | 4688篇 |
口腔科学 | 788篇 |
临床医学 | 3249篇 |
内科学 | 6434篇 |
皮肤病学 | 481篇 |
神经病学 | 3146篇 |
特种医学 | 1274篇 |
外国民族医学 | 1篇 |
外科学 | 4623篇 |
综合类 | 272篇 |
一般理论 | 86篇 |
预防医学 | 2437篇 |
眼科学 | 600篇 |
药学 | 2312篇 |
中国医学 | 31篇 |
肿瘤学 | 1891篇 |
出版年
2023年 | 144篇 |
2022年 | 214篇 |
2021年 | 648篇 |
2020年 | 418篇 |
2019年 | 672篇 |
2018年 | 750篇 |
2017年 | 564篇 |
2016年 | 698篇 |
2015年 | 723篇 |
2014年 | 1020篇 |
2013年 | 1583篇 |
2012年 | 2078篇 |
2011年 | 2295篇 |
2010年 | 1240篇 |
2009年 | 1109篇 |
2008年 | 1912篇 |
2007年 | 2038篇 |
2006年 | 1862篇 |
2005年 | 1840篇 |
2004年 | 1778篇 |
2003年 | 1587篇 |
2002年 | 1672篇 |
2001年 | 276篇 |
2000年 | 191篇 |
1999年 | 267篇 |
1998年 | 367篇 |
1997年 | 338篇 |
1996年 | 294篇 |
1995年 | 251篇 |
1994年 | 257篇 |
1993年 | 233篇 |
1992年 | 169篇 |
1991年 | 149篇 |
1990年 | 142篇 |
1989年 | 139篇 |
1988年 | 131篇 |
1987年 | 134篇 |
1986年 | 130篇 |
1985年 | 153篇 |
1984年 | 161篇 |
1983年 | 148篇 |
1982年 | 223篇 |
1981年 | 193篇 |
1980年 | 192篇 |
1979年 | 101篇 |
1978年 | 124篇 |
1977年 | 122篇 |
1976年 | 101篇 |
1974年 | 107篇 |
1973年 | 83篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Carl Mindell M.D. 《The Psychiatric quarterly》1994,65(1):31-47
This article describes aspects of the impact of shame and contempt in psychotherapy and in our daily lives. Psychotherapy
is seen as moving between the poles of shame and hope. Shame-anxiety alerts us to the imminent danger of being shamed; shame
is described as the experience of finding our individuality unacceptable and contempt is seen as a means of coping with shame
where the other is made to feel one's shame. Examples of each are provided as well as comments about psychotherapy issues
with patients who exhibit shame-anxiety, shame and contempt. Shame-anxiety, shame, contempt and tyranny are seen as points
along a spectrum of humiliation experiences.
Presented at Department of Psychiatry Grand Rounds, Albany Medical College, March 1990, and University of Natal Faculty of
Medicine (South Africa), November, 1990. 相似文献
82.
83.
84.
Ronald D. Curran M.D. Constantine Mavroudis M.D. Carl L. Backer M.D. 《Journal of cardiac surgery》1997,12(6):372-379
A bstract Background : Ventricular-to-pulmonary artery conduits in growing patients with congenital heart disease will require replacement from time to time due to somatic growth, neointimal hyperplasia, and pulmonary artery stenosis. The purpose of this article is to review our experience with ascending aortic extension for significant long-segment pulmonary artery stenosis in patients undergoing reoperation for right ventricular-to-pulmonary artery conduit replacement. Methods : From 1989 to 1997, 8 patients had aortic transection, right pulmonary artery augmentation arterioplasty, and aortic interposition graft (Hemashield in 7 and Gore-tex in 1) in association with right ventricular-to-pulmonary artery conduit replacement in 7 patients and completion Fontan operation in 1 patient. Aortic cross-clamp time was 90 ± 34 minutes, and the cardiopulmonary bypass time was 205 ± 37 minutes. Results : All patients survived. In those 7 patients who had conduit replacement, the RV/LV ratio declined from 0.78 ± 0.15 to 0.45 ±; 0.05 postoperatively (P < 0.05). Average length of stay was 8.9 ± 7.2 days. Follow-up range is 18 months to 8 years (mean 4 years). Two complications included cardiac transplantation for pre-existing poor left ventricular function and accelerated conduit stenosis leading to conduit re-replacement. Conclusion : Ascending aortic extension facilitates long-segment pulmonary artery augmentation arterioplasty and enlarges the retroaortic space, preventing future compression restenosis. 相似文献
85.
Yanfei L Ma Qingqiang Zeng David W Donley Louis-Georges Ste-Marie J Christopher Gallagher Gail P Dalsky Robert Marcus Erik Fink Eriksen 《Journal of bone and mineral research》2006,21(6):855-864
Transiliac bone biopsies were obtained from 55 women treated with teriparatide or placebo for 12-24 months. We report direct evidence that modeling bone formation at quiescent surfaces was present only in teriparatide-treated patients and bone formation at remodeling sites was higher with teriparatide than placebo. INTRODUCTION: Recombinant teriparatide [human PTH(1-34)], a bone formation agent for the treatment of osteoporosis when given once daily subcutaneously, increases biochemical markers of bone turnover and activation frequency in histomorphometry studies. MATERIALS AND METHODS: We studied the mechanisms underlying this bone-forming action of teriparatide at the basic multicellular unit by the appearance of cement lines, a method used to directly classify surfaces as modeling or remodeling osteons, and by the immunolocalization of IGF-I and IGF-II. Transiliac bone biopsies were obtained from 55 postmenopausal women treated with teriparatide 20 or 40 microg or placebo for 12-24 months (median, 19.8 months) in the Fracture Prevention Trial. RESULTS: A dose-dependent relationship was observed in modeling and mixed remodeling/modeling trabecular hemiosteons. Trabecular and endosteal hemiosteon mean wall thicknesses were significantly higher in both teriparatide groups than in placebo. There was a dose-dependent relationship in IGF-II immunoreactive staining at all bone envelopes studied. The greater local IGF-II presence after treatment with teriparatide may play a key role in stimulating bone formation. CONCLUSIONS: Direct evidence is presented that 12-24 months of teriparatide treatment induced modeling bone formation at quiescent surfaces and resulted in greater bone formation at remodeling sites, relative to placebo. 相似文献
86.
Kathryn K Bucci Carl J Possidente Kathleen A Talbot 《American journal of health-system pharmacy》2003,60(24):2601-2605
87.
Synaptically evoked membrane potential oscillations induced by substance P in lamprey motor neurons.
Short-lasting application (10 min) of tachykinin neuropeptides evokes long-lasting (>24 h) modulation of N-methyl-D-aspartate (NMDA)-evoked locomotor network activity in the lamprey spinal cord. In this study, the net effects of the tachykinin substance P on the isolated spinal cord have been examined by recording from motor neurons in the absence of NMDA and ongoing network activity. Brief bath application of substance P (30 s to 2 min) induced irregular membrane potential oscillations in motor neurons. These oscillations consisted of depolarizing and hyperpolarizing phases and were associated with phasic ventral-root activity. The oscillations were blocked by the tachykinin antagonist spantide II. They were also blocked by tetrodotoxin (TTX), suggesting that they were not dependent on intrinsic membrane properties of the motor neurons but were synaptically mediated. Substance P could also have a direct effect, however, because a membrane potential depolarization persisted in the presence of TTX. Protein kinase agonists and antagonists were used to investigate the intracellular pathways through which substance P acted. The oscillations were blocked by the selective protein kinase C (PKC) antagonist chelerythrine. However, the TTX-resistant membrane potential depolarization was not significantly affected by blocking PKC. The protein kinase A and G antagonist H8 did not affect either the oscillations or the direct TTX-resistant membrane potential depolarization. The glutamate receptor antagonist kynurenic acid abolished the substance-P-evoked oscillations, suggesting that they were dependent on glutamate release. The oscillations were abolished or reduced by the AMPA/kainate receptor antagonist 6-cyano-7-nitroquinoxalene-2,3-dione but were only reduced by the NMDA receptor antagonist D-AP5. The oscillations were thus mediated by glutamatergic inputs with a greater dependence on non-NMDA receptors. Blocking glycinergic inputs with strychnine resulted in large depolarizing plateaus and bursts of spikes. The glutamatergic and glycinergic inputs underlying the oscillations are apparently evoked through direct and indirect excitatory effects on inhibitory and excitatory premotor interneurons. Substance P thus has a distributed excitatory effect in the spinal cord. While it can activate premotor networks, this activation alone is not able to evoke a coordinated behaviorally relevant motor output. 相似文献
88.
89.
Carl L. Nelson Sandra G. Hickmon Robert A. Skinner 《Journal of orthopaedic research》1997,15(2):249-255
Osteomyelitis was induced in the radius in 77 rabbits and confirmed by histological examination and culture. At 4 weeks, the wounds were debrided and the animals were treated with (a) fatty acid dimersebacic acid beads (a bioerodable composite) impregnated with 20% or (b) 10% gentamicin sulfate, (c) placebo beads and intramuscular gentamicin sulfate. (d) placebo beads alone, or (e) debridement only. After 4 weeks, eradication of infection was determined by histological examination and culture. Osteomyelitis was eradicated in 93% of the animals treated with the beads and 20% gentamicin, in 67% of those treated with the beads arid 10% gentamicin, in 25% of those treated with placebo beads and intramuscular gentamicin, in 7% of those treated with placebo beads alone, and in 12.5% of those treated with debridement only (p values from <0.001 to 0.02). Fatty acid dimer-sehacie acid beads with gentamicin were then implanted in noninfected rabbits, and gentamicin sulfate concentrations in bone, serum, urine, and wound exudate were measured. Gentamicin sulfate was detectable in bone for as long as 8 weeks after implantation. Levels as high as 4,746 g/ml were present in the wound exudate for the first 7 days. Levels in the serum peaked at 1.03 μg/ml. Urine levels peaked at 135 μg/ml. 相似文献
90.