全文获取类型
收费全文 | 1633篇 |
免费 | 171篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 49篇 |
妇产科学 | 29篇 |
基础医学 | 259篇 |
口腔科学 | 34篇 |
临床医学 | 156篇 |
内科学 | 422篇 |
皮肤病学 | 63篇 |
神经病学 | 123篇 |
特种医学 | 35篇 |
外科学 | 160篇 |
综合类 | 6篇 |
一般理论 | 2篇 |
预防医学 | 193篇 |
眼科学 | 9篇 |
药学 | 97篇 |
中国医学 | 3篇 |
肿瘤学 | 162篇 |
出版年
2024年 | 2篇 |
2023年 | 9篇 |
2022年 | 31篇 |
2021年 | 58篇 |
2020年 | 37篇 |
2019年 | 51篇 |
2018年 | 71篇 |
2017年 | 39篇 |
2016年 | 53篇 |
2015年 | 53篇 |
2014年 | 61篇 |
2013年 | 87篇 |
2012年 | 136篇 |
2011年 | 149篇 |
2010年 | 66篇 |
2009年 | 81篇 |
2008年 | 130篇 |
2007年 | 122篇 |
2006年 | 106篇 |
2005年 | 107篇 |
2004年 | 89篇 |
2003年 | 63篇 |
2002年 | 67篇 |
2001年 | 15篇 |
2000年 | 11篇 |
1999年 | 6篇 |
1998年 | 10篇 |
1997年 | 7篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 7篇 |
1993年 | 6篇 |
1992年 | 4篇 |
1991年 | 8篇 |
1990年 | 8篇 |
1989年 | 14篇 |
1988年 | 12篇 |
1987年 | 11篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1979年 | 1篇 |
1974年 | 1篇 |
1971年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有1808条查询结果,搜索用时 15 毫秒
41.
42.
43.
Ravel Jean-Marie Benkirane Mehdi Calmels Nadège Marelli Cecilia Ory-Magne Fabienne Ewenczyk Claire Halleb Yosra Tison François Lecocq Claire Pische Guillaume Casenave Philippe Chaussenot Annabelle Frismand Solène Tyvaert Louise Larrieu Lise Pointaux Morgane Drouot Nathalie Bossenmeyer-Pourié Carine Oussalah Abderrahim Guéant Jean-Louis Leheup Bruno Bonnet Céline Anheim Mathieu Tranchant Christine Lambert Laëtitia Chelly Jamel Koenig Michel Renaud Mathilde 《Journal of neurology》2021,268(5):1927-1937
Journal of Neurology - STUB1 has been first associated with autosomal recessive (SCAR16, MIM# 615768) and later with dominant forms of ataxia (SCA48, MIM# 618093). Pathogenic variations in STUB1... 相似文献
44.
In this issue of Blood, Khorana and colleagues report a simple and practical model for the prediction of symptomatic venous thrombosis after the initiation of chemotherapy in cancer outpatients. 相似文献
45.
Localization and determination of infarct size by Gd-Mesoporphyrin enhanced MRI in dogs 总被引:2,自引:0,他引:2
Paul Herijgers Sarra K. Laycock Yicheng Ni Guy Marchal Jan Bogaert Hilde Bosmans Carine Petr´ Willem Flameng 《The International Journal of Cardiac Imaging》1997,13(6):499-507
Background: Accurate localization and sizing of a myocardial infarction are necessary for clinical decision making and even more in research. Gd-Mesoporphyrin enhanced magnetic resonance imaging (MRI) was recently shown to specifically delineate necrosis in liver tumors, renal and muscle necrosis and myocardial infarction in rats. In this study, we investigated this technique's potential to accurately delineate myocardial infarction in a larger animal species, the dog. Methods: Myocardial infarction was induced in 8 dogs by ligation of the left anterior descending coronary artery, 4 of which were reperfused after 3 hr. Gd-Mesoporphyrin (0.05 mmol/kg) was injected intravenously 210 min after the onset of ischemia (n = 6) or after 24 hr in 2 dogs with non-reperfused infarctions. MRI was performed 10 hr. after administration of Gd-Mesoporphyrin. In vivo MRI consisted of EKG-triggered, respiratory gated T1-weighted spin echo and segmented turboFLASH long and short axis measurements. Post-mortem, a spin echo short axis measurement was repeated. Infarct size was determined planimetrically by TTC staining of left ventricular slices. Results: In all instances, there was a very close qualitative agreement between the MRI and TTC defined myocardial infarction. Quantitatively, the linear regression from post-mortem MRI to TTC determined infarct size yielded a result very close to the line of identity (regression coefficient: 0.980 ± 0.026, p<0.000001, adjusted R2 = 0.964). Conclusion: We conclude that Gd-Mesoporphyrin enhanced MRI is a promising tool for the accurate delineation of myocardial infarction. 相似文献
46.
Manoela Carrera Carolina C Bitu Carine Ervolino de Oliveira Nilva K Cervigne Edgard Graner Aki Manninen Tuula Salo Ricardo D Coletta 《International journal of clinical and experimental pathology》2015,8(4):3613-3623
Although HOX genes are best known for acting in the regulation of important events during embryogenesis, including proliferation, differentiation and migration, alterations in their expression patterns have been frequently described in cancers. In previous studies we analyzed the expression profile of the members of the HOX family of homeobox genes in oral samples of normal mucosa and squamous cell carcinoma (OSCC) and identified differently expressed genes such as HOXA10. The present study aimed to validate the increased expression of HOXA10 in OSCCs, and to investigate the effects arising from its knockdown in OSCC cells. The levels of HOXA10 mRNA were determined in human OSCC samples and cell lines by quantitative PCR, and HOXA10-mediated effects on proliferation, apoptosis, adhesion, epithelial-mesenchymal transition (EMT), migration and invasion were studied in HSC-3 tongue carcinoma cells by using retrovirus-mediated RNA interference. Higher expression of HOXA10 mRNA was observed in OSCC cell lines and in tumor tissues compared to normal controls. HOXA10 knockdown significantly reduced the proliferation of the tumor cells which was accompanied by increased levels of p21. HOXA10 silencing also significantly induced the expression of EMT markers and enhanced the adhesion, migration and invasion of HSC-3 cells. No effects on cell death were observed after HOXA10 knockdown. The results of the current study confirm the overexpression of HOXA10 in OSCCs, and further demonstrate that its expression is functionally associated with several important biological processes related to oral tumorigenesis, such as proliferation, migration and invasion. 相似文献
47.
Christian P Vink Charlotte W Ockeloen Sietske ten Kate David A Koolen Johannes Kristian Ploos van Amstel Anne-Marie Kuijpers-Jagtman Celeste C van Heumen Tjitske Kleefstra Carine E L Carels 《European journal of human genetics : EJHG》2014,22(9):1063-1070
This article describes the inter- and intra-familial phenotypic variability in four families with WNT10A mutations. Clinical characteristics of the patients range from mild to severe isolated tooth agenesis, over mild symptoms of ectodermal dysplasia, to more severe syndromic forms like odonto-onycho-dermal dysplasia (OODD) and Schöpf–Schulz–Passarge syndrome (SSPS). Recurrent WNT10A mutations were identified in all affected family members and the associated symptoms are presented with emphasis on the dentofacial phenotypes obtained with inter alia three-dimensional facial stereophotogrammetry. A comprehensive overview of the literature regarding WNT10A mutations, associated conditions and developmental defects is presented. We conclude that OODD and SSPS should be considered as variable expressions of the same WNT10A genotype. In all affected individuals, a dished-in facial appearance was observed which might be helpful in the clinical setting as a clue to the underlying genetic etiology. 相似文献
48.
Toplak N Frenkel J Ozen S Lachmann HJ Woo P Koné-Paut I De Benedetti F Neven B Hofer M Dolezalova P Kümmerle-Deschner J Touitou I Hentgen V Simon A Girschick H Rose C Wouters C Vesely R Arostegui J Stojanov S Ozgodan H Martini A Ruperto N Gattorno M;Paediatric Rheumatology International Trials Organisation 《Annals of the rheumatic diseases》2012,71(7):1177-1182
49.
This review defines the concepts of maternal-fetal (congenital) and vertical transmissions (mother-to-child) of pathogens and specifies the human parasites susceptible to be congenitally transferred. It highlights the epidemiological features of this transmission mode for the three main congenital parasitic infections due to Toxoplasma gondii, Trypanosoma cruzi and Plasmodium sp. Information on the possible maternal-fetal routes of transmission, the placental responses to infection and timing of parasite transmission are synthesized and compared. The factors susceptible to be involved in parasite transmission and development of congenital parasitic diseases, such as the parasite genotypes, the maternal co-infections and parasitic load, the immunological features of pregnant women and the capacity of some fetuses/neonates to overcome their immunological immaturity to mount an immune response against the transmitted parasites are also discussed and compared. Analysis of clinical data indicates that parasitic congenital infections are often asymptomatic, whereas symptomatic newborns generally display non-specific symptoms. The long-term consequences of congenital infections are also mentioned, such as the imprinting of neonatal immune system and the possible trans-generational transmission. The detection of infection in pregnant women is mainly based on standard serological or parasitological investigations. Amniocentesis and cordocentesis can be used for the detection of some fetal infections. The neonatal infection can be assessed using parasitological, molecular or immunological methods; the place of PCR in such neonatal diagnosis is discussed. When such laboratory diagnosis is not possible at birth or in the first weeks of life, standard serological investigations can also be performed 8-10 months after birth, to avoid detection of maternal transmitted antibodies. The specific aspects of treatment of T. gondii, T. cruzi and Plasmodium congenital infections are mentioned. The possibilities of primary and secondary prophylaxes, as well as the available WHO corresponding recommendations are also presented. 相似文献
50.