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21.
Rantanen T Masaki K He Q Ross GW Willcox BJ White L 《Age (Dordrecht, Netherlands)》2012,34(3):563-570
We studied prospectively the midlife handgrip strength, living habits, and parents’ longevity as predictors of length of life
up to becoming a centenarian. The participants were 2,239 men from the Honolulu Heart Program/Honolulu–Asia Aging Study who
were born before the end of June 1909 and who took part in baseline physical assessment in 1965–1968, when they were 56–68 years
old. Deaths were followed until the end of June 2009 for 44 years with complete ascertainment. Longevity was categorized as
centenarian (≥100 years, n = 47), nonagenarian (90–99 years, n = 545), octogenarian (80–89 years, n = 847), and ≤79 years (n = 801, reference). The average survival after baseline was 20.8 years (SD = 9.62). Compared with people who died at the age
of ≤79 years, centenarians belonged 2.5 times (odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.23–5.10) more often
to the highest third of grip strength in midlife, were never smokers (OR = 5.75 95% CI = 3.06–10.80), had participated in
physical activity outside work (OR = 1.13 per daily hour, 95% CI = 1.02–1.25), and had a long-lived mother (≥80 vs. ≤60 years,
OR = 2.3, 95% CI = 1.06–5.01). Associations for nonagenarians and octogenarians were parallel, but weaker. Multivariate modeling
showed that mother’s longevity and offspring’s grip strength operated through the same or overlapping pathway to longevity.
High midlife grip strength and long-lived mother may indicate resilience to aging, which, combined with healthy lifestyle,
increases the probability of extreme longevity. 相似文献
22.
Chuang TW Hockett CW Kightlinger L Wimberly MC 《The American journal of tropical medicine and hygiene》2012,86(4):724-731
Understanding the landscape-level determinants of West Nile virus (WNV) can aid in mapping high-risk areas and enhance disease control and prevention efforts. This study analyzed the spatial patterns of human WNV cases in three areas in South Dakota during 2003-2007 and investigated the influences of land cover, hydrology, soils, irrigation, and elevation by using case-control models. Land cover, hydrology, soils, and elevation all influenced WNV risk, although the main drivers were different in each study area. Risk for WNV was generally higher in areas with rural land cover than in developed areas, and higher close to wetlands or soils with a high ponding frequency. In western South Dakota, WNV risk also decreased with increasing elevation and was higher in forested areas. Our results showed that the spatial patterns of human WNV risk were associated with landscape-level features that likely reflect variability in mosquito ecology, avian host communities, and human activity. 相似文献
23.
Baričević M Ratkaj I Mladinić M Zelježić D Kraljević SP Lončar B Stipetić MM 《Clinical oral investigations》2012,16(1):325-331
Given long-term effect on oral tissues due to contact with dental appliances, the biocompatibility studies of casting alloys
are of great importance. It has been previously documented that metal dental appliances, due to corrosion, might induce genotoxic
and mutagenic effects in cells. Therefore, the aim of presented study was to examine the genotoxicity of two dental casting
alloys (Co-Cr-Mo and Ni-Cr) commonly used in fixed and removable prosthodontic appliances that are in contact with the oral
epithelium for 5 years or more. For that purpose, 55 age-matched subjects were included in the study; 30 wearers of prosthodontic
appliances and 25 controls. Buccal cells of oral mucosa were collected and processed for further analysis. The cell viability
has been assessed by trypan blue exclusion test, while genotoxic effect of metal ions on DNA in oral mucosa cells was studied
by use of alkaline comet assay. Results have shown significantly higher comet assay parameters (tail length and percentage
DNA in the tail) in the group wearing metal appliances. Both subjects with Co-Cr-Mo alloy and Ni-Cr alloy showed significantly
higher comet assay parameters when compared with controls. It has been confirmed that metal ions released by the two base
metal dental casting alloys examined in this study, might be responsible for DNA damage of oral mucosa cells. Therefore, the
results of this study emphasize the importance of the in vivo evaluation of dental materials with respect to their genotoxicity,
which is of major importance to ensure long-term biocompatibility. 相似文献
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26.
Dimitra Zannidi Kalliopi Karatzi Eva Karaglani Stavros Liatis Greet Cardon Violeta Iotova Kaloyan Tsochev Nevyana Chakarova Luis A. Moreno Paloma Flores-Barrantes Sándorné Radó Imre Rurik Jaana Lindström Konstantinos Makrilakis Yannis Manios the FeelDiabetes Study Group 《Journal of human nutrition and dietetics》2023,36(1):62-74
27.
Peila R Yucesoy B White LR Johnson V Kashon ML Wu K Petrovitch H Luster M Launer LJ 《Neurobiology of aging》2007,28(9):1367-1373
The transforming growth factor-beta1 (TGF-beta1) is involved in post-ischemic neuronal rescue and in beta-amyloid turn-over. We hypothesized that the risk for dementia and related neuropathologies is modified by the TGF-beta1 functional genetic variants. The association of the TGF-beta1+29T-->C polymorphism with dementia was examined in a sample of 261 cases and 491 controls from the Honolulu-Asia Aging Study, including 282 subjects with autopsy data. Dementia was assessed in 1991 and 1994 by a multi-step protocol and standardized diagnostic criteria. The analysis was adjusted for demographic and vascular factors. Compared to the TT genotype, the TC and the CC genotypes were associated with a reduced risk for vascular dementia (OR(TC)=0.28, 95% confidence interval (CI): 0.1-0.9; OR(CC)=0.28, CI: 0.1-0.9), microinfarcts (OR(CC)=0.31, CI: 0.13-0.71) and cerebral amyloid angiopathy (OR(CC)=0.48, CI: 0.2-0.9). The CC genotype was associated with an increase risk of neocortical plaques (OR(CC)=4.34, CI: 1.6-11.8). These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia. 相似文献
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29.
Pathogen recognition and binding are crucial functions of innate immunity. It has been observed that the short pentraxin superfamily including C-reactive protein (CRP) and serum amyloid P component are pathogen pattern recognition receptors (PRR) in the plasma. We isolated and characterized a novel and distinctive pentraxin from the plasma of horseshoe crab, Carcinoscorpius rotundicauda, henceforth named CrOctin, which binds to bacteria via phosphoethanolamine (PE), a chemical component present on lipid A and core polysaccharide moieties of bacterial lipopolysaccharide (LPS). Infection enhances the formation of the PRR interactome constituting CrOctin, CRP and galactose-binding protein. In particular, infection increases the affinity of CRP to CrOctin by 1000-fold. Furthermore, we observed that by binding to PE, CrOctin acts as a linker that bridges the PRR interactome to the inner core of LPS. On the other hand, under normal physiological conditions, binding of CrOctin to PE appears to obscure other PRR from interacting directly with PE. Interestingly, the cluster of "CrOctin-interactive PRR" is sex specific. We report, for the first time, the change in PRR protein profiles with a distinctive gender difference during Pseudomonas infection. 相似文献
30.
Michael T. Stallings Brandon R. Cardon Jeremy M. Hardman Tyler A. BlissScott E. Brunson Chris M. HartMaria D. Swiss Squire D. HepworthMerrill J. Christensen Chad R. Hancock 《Nutrition Research》2014
Selenium (Se) has been implicated as a micronutrient that decreases adenosine monophosphate–activated protein kinase (AMPK) signaling and may increase diabetes risk by reducing insulin sensitivity. Soy isoflavones (IF) are estrogen-like compounds that have been shown to attenuate insulin resistance, hyperglycemia, adiposity, and increased AMPK activation. We hypothesized that a high IF (HIF) diet would prevent the poor metabolic profile associated with high Se intake. The purpose of this study was to examine changes in basal glucose metabolism and AMPK signaling in response to an HIF diet and/or supplemental Se in a mouse model. Male FVB mice were divided into groups receiving either a control diet with minimal IF (low IF) or an HIF diet. Each dietary group was further subdivided into groups receiving either water or Se at a dose of 3 mg Se/kg body weight daily, as Se-methylselenocysteine (SMSC). After 5 months, mice receiving SMSC had elevated fasting glucose (P < .05) and a tendency for glucose intolerance (P = .08). The increase in dietary IF did not result in improved fasting blood glucose. Interestingly, after 6 months, HIF-fed mice had decreased basal AMPK activation in liver and skeletal muscle tissue (P < .05). Basal glucose metabolism was changed by SMSC supplementation as evidenced by increased fasting blood glucose and glucose intolerance. High dietary IF levels did not protect against aberrant blood glucose. In FVB mice, decreased basal AMPK activation is not the mechanism through which Se exerts its effect. These results suggest that more research must be done to elucidate the role of Se and IF in glucose metabolism. 相似文献