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601.
Davie AP; Francis CM; Caruana L; Sutherland GR; McMurray JJ 《QJM : monthly journal of the Association of Physicians》1997,90(5):335-339
We assessed the value of symptoms, past history, medications and signs in
the evaluation of patients who might have heart failure secondary to left
ventricular systolic dysfunction. An open-access echocardiography service
was set up to help identify patients with left ventricular systolic
dysfunction who might benefit from treatment with an
angiotensin-converting-enzyme inhibitor. History and examination were
recorded for each of these patients. The patients were divided into groups
according to whether left ventricular systolic function was preserved or
not and whether various clinical features were present or not. Of 259
consecutive patients studied, 41 had impairment of left ventricular
systolic function as assessed by echocardiography. Past history of
myocardial infarction and displaced apex beat were the best single
predictors of left ventricular systolic dysfunction as assessed by
echocardiography. The combination of past history of myocardial infarction
and displaced apex had the best positive predictive value of all. Patients
with such clinical features or combinations of clinical features may not
need echocardiography, and where access to this resource is limited, it
could be reserved for patients without such diagnostic features.
相似文献
602.
The neutrophil-specific NB antigen system has been serologically characterized with human alloantisera. Two alleles, NB1 and NB2, have been described; however, there may be important quantitative or qualitative variation in the expression of NB1 and NB2. Human alloantibodies have been used to identify the 58- to 64-kDa glycoprotein (GP) on which NB1 antigen is located, but an NB2 antigen- bearing molecule has not yet been identified. To identify the NB2 molecule, human alloantibody to NB1 was used to isolate the 58- to 64- kDa NB1 GP, and rabbits were immunized with this GP. Two rabbit antisera were produced. Both antisera immunoblotted and immunoprecipitated the 58- to 64-kDa GP on which NB1 is located, but neither identified the molecule on which NB2 is located. The inability of two rabbit polyclonal antibodies specific for the NB1 molecule to react with the NB2-bearing molecule suggests that considerable differences may exist between these two molecules or that NB2 as currently defined is not related to NB1. 相似文献
603.
Autoimmunity as an aetiological factor in vitiligo 总被引:2,自引:0,他引:2
N Rezaei†‡ NG Gavalas‡ AP Weetman‡ EH Kemp‡ 《Journal of the European Academy of Dermatology and Venereology》2007,21(7):865-876
Vitiligo is a common dermatological disorder characterized by the presence on the skin of depigmented macules resulting from the destruction of cutaneous melanocytes. Autoimmunity is an important hypothesis with regard to vitiligo aetiology and the evidence for autoimmune responses being involved in the pathogenesis of this disorder will be discussed in the present review. All immune system compartments, including innate and adaptive immunity have been implicated in vitiligo development. Particularly relevant are autoantibodies and autoreactive T cells in vitiligo patients that have cytotoxic effects upon pigment cells. Furthermore, predisposition to vitiligo appears to be associated with certain alleles of the major histocompatibility complex class II antigens as well as with other autoimmune-susceptibility genes. Moreover, the association of vitiligo with autoimmune disorders, the animal models of the disease, and the positive response to immunosuppressive therapeutic agents emphasize the role of autoimmunity in the development of this disorder. 相似文献
604.
Adriano Jaskonis DallOlio Gustavo de S Schiavo Matias Ana Claudia Oliveira Carreira Hianka Jasmyne Costa de Carvalho Thais van den Broek Campanelli Thamires Santos da Silva Mnica Duarte da Silva Ana Lúcia Abreu-Silva Maria Anglica Miglino 《Materials》2022,15(17)
Complex wounds in dogs are a recurrent problem in veterinary clinical application and can compromise skin healing; in this sense, tissue bioengineering focused on regenerative medicine can be a great ally. Decellularized and recellularized skin scaffolds are produced to be applied in different and complex canine dermal wounds in the present investigation. Dog skin fragments are immersed in a 0.5% sodium dodecyl sulfate (SDS) solution at room temperature and overnight at 4 °C for 12 days. Decellularized samples are evaluated by histological analysis, scanning electron microscopy (SEM) and gDNA quantification. Some fragments are also recellularized using mesenchymal stem cells (MSCs). Eight adult dogs are divided into three groups for the application of the decellularized (Group I, n = 3) and recellularized scaffolds (Group II, n = 3) on injured areas, and a control group (Group III, n = 2). Wounds are evaluated and measured during healing, and comparisons among the three groups are described. In 30- and 60-day post-grafting, the histopathological analysis of patients from Groups I and II shows similar patterns, tissue architecture preservation, epithelial hyperplasia, hyperkeratosis, edema, and mononuclear inflammatory infiltrate. Perfect integration between scaffolds and wounds, without rejection or contamination, are observed in both treated groups. According to these results, decellularized skin grafts may constitute a potential innovative and functional tool to be adopted as a promising dog cutaneous wound treatment. This is the first study that applies decellularized and recellularized biological skin grafts to improve the healing process in several complex wounds in dogs, demonstrating great potential for regenerative veterinary medicine progress. 相似文献
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607.
Yvonne Nong MS Jessica Maloh ND Nicole Natarelli BA Hemali B. Gunt PhD Esther Tristani PhD Raja K. Sivamani MD MS AP 《Journal of Cosmetic Dermatology》2023,22(8):2166-2173
Background
Beeswax is a naturally occurring product secreted from worker bees that has varied uses in modern day. In skincare, its function ranges from its role as an occlusive, helping to create a semi-occlusive skin barrier that minimizes transepidermal water loss; as a humectant, locking in hydration; and an emollient to soften and soothe the skin. As a natural substance, its use has been shown to help alleviate symptoms associated with common cutaneous conditions like dermatitis, psoriasis, and overgrowth of normal skin flora.Aims
In this narrative review, we aim to describe current uses of beeswax in skincare that has been published in the literature.Materials and methods
A review of beeswax related publications was performed by searching the PubMed database studies.Results
A total of five clinical studies were included with three studies on animals and two studies in humans.Discussion
Several studies show the benefits of topical beeswax in supporting the skin barrier.Conclusion
Beeswax can be a low-cost, natural ingredient for use in products. Further studies with topical beeswax are warranted. 相似文献608.
Aiolfi A. Cavalli M. Gambero F. Mini E. Lombardo F. Gordini L. Bonitta G. Bruni P. G. Bona D. Campanelli G. 《Hernia》2023,27(2):213-224
Hernia - Incisional hernia (IH) is a common complication after abdominal surgery. Prevention of IH is matter of intense research. Prophylactic mesh reinforcement (PMR) has been shown to be... 相似文献
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