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81.
We describe a 63-year-old man who presented with painful malodorous lesions in the perianal, perineal and scrotal regions. Following definitive diagnosis of paracoccidioidomycosis, he was treated initially with trimethoprim/sulphamethoxazole, but there was no clinical improvement. He then received terbinafine (Lamisil) 250 mg twice daily for 6 months. There was rapid resolution of all lesions and complete relief of symptoms, without any associated side-effects. The patient remains clinically well and without any evidence of infection 2 years after discontinuation of terbinafine treatment. 相似文献
82.
Pawlik M Sastre M Calero M Mathews PM Schmidt SD Nixon RA Levy E 《Journal of molecular neuroscience : MN》2004,22(1-2):13-18
Cystatin C, an inhibitor of cysteine proteases, colocalizes with amyloid β (Aβ) in parenchymal and vascular amyloid deposits
in brains of Alzheimer’s disease (AD) patients, suggesting that cystatin C has a role in AD. Cystatin C also colocalizes with
β amyloid precursor protein (βAPP) in transfected cultured cells. In vitro analysis of the association between the two proteins
revealed that binding of cystatin C to full-length βAPP does not affect the level of Aβ secretion. Here we studied the effect
of in vivo overexpression of cystatin C on the levels of endogenous brain Aβ. We have generated lines of transgenic mice expressing
either wild-type human cystatin C or the Leu68Gln variant that forms amyloid deposits in the cerebral vessels of Icelandic
patients with hereditary cerebral hemorrhage, under control sequences of the human cystatin C gene. Western blot analysis
of brain homogenates was used to select lines of mice expressing various levels of the transgene. Analysis of Aβ40 and Aβ42
concentrations in the brain showed no difference between transgenic mice and their nontransgenic littermates. Thus, in vivo
overexpression of human cystatin C does not affect Aβ levels in mice that do not deposit Aβ. 相似文献
83.
Castaño Zapatero I Esteban Sánchez T Díaz Caparrós F Calero Del Castillo JB 《Acta otorrinolaringologica espanola》2000,51(1):46-51
Since 1992, when our department acquired a flexible fiberscope with a working channel, we have used it in surgery on the upper respiratory and digestive tract. We call our technique laryngeal fiberscopic surgery. We report the results of four years of experience in this field. A total of 368 surgical interventions were performed, almost half to remove benign lesions of the vocal cords (polyps, nodules, etc). This technique is a major advance in our field of study. Its main advantages are avoidance of general anesthesia and hospitalization, reduction of surgical risk, and savings of time and money. We consider it to be a useful alternative to traditional direct laryngoscopy (Kleinsasser technique) for many applications. 相似文献
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F. Calero F. Rodriguez-Escudero J. Jimeno J. Menda a J. Iglesias F. Murillo F. Ugalde A. Armas A. Rementeria J. Asins J. Diaz-Castellanos 《Acta oncologica (Stockholm, Sweden)》1991,30(3):325-327
Thirty consecutive patients with FIGO stage III-IV, squamous cell uterine cervix cancer were entered in a phase II trial evaluating activity and safety of epirubicin when given at a dose of 80 mg/m2 i.v., every 3 weeks. Two complete responses (including a pathological complete remission) plus 3 partial responses were observed among 27 evaluable patients with a response rate of 18.5% (95% confidence limits = 7.6%-36.4%). the median time to progression and median survival for all treated patients were 3 and 8 months respectively. Treatment was well tolerated. Haematological toxicity was mild. WHO grade 4 toxicity was not observed. the median total cumulative dose of epirubicin was 360 mg/m2 (80-840 mg/m2). Congestive heart failure was not noted. Further studies in cervical cancer with higher doses of epirubicin as single agent or in combination with other non-myelotoxic drugs are indicated. 相似文献
86.
Tanios Bekaii-Saab Nita Williams Christoph Plass Miguel Villalona Calero Charis Eng 《BMC cancer》2006,6(1):278-5
Background
Several studies showed that gain-of-function somatic mutations affecting the catalytic domain of EGFR in non-small cell lung carcinomas were associated with response to gefitinib and erlotinib, both EGFR -tyrosine kinase inhibitors. In addition, 4% of non-small cell lung carcinomas were shown to have ERBB2 mutations in the kinase domain. In our study, we sought to determine if similar respective gain-of-function EGFR and ERBB2 mutations were present in hepatoma and/or biliary cancers. 相似文献87.
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Doménico Fraccalvieri Esther Kreisler Moreno Blas Flor Lorente Antonio Torres García Alberto Muñoz Calero Francisco Mateo Vallejo Sebastiano Biondo 《Cirugía espa?ola》2014