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891.
Quintero E Castells A Bujanda L Cubiella J Salas D Lanas Á Andreu M Carballo F Morillas JD Hernández C Jover R Montalvo I Arenas J Laredo E Hernández V Iglesias F Cid E Zubizarreta R Sala T Ponce M Andrés M Teruel G Peris A Roncales MP Polo-Tomás M Bessa X Ferrer-Armengou O Grau J Serradesanferm A Ono A Cruzado J Pérez-Riquelme F Alonso-Abreu I de la Vega-Prieto M Reyes-Melian JM Cacho G Díaz-Tasende J Herreros-de-Tejada A Poves C Santander C González-Navarro A;COLONPREV Study Investigators 《The New England journal of medicine》2012,366(8):697-706
892.
M. Sánchez Sevilla J.A. García Mejido E. Iglesias Bravo J.A. Sainz Bueno C. Delgado Jiménez R. Garrido Teruel 《Clínica e investigación en ginecología y obstetricia》2014
Ectopic breast tissue occurs in 2-6% of the general population. The most frequent location is the axillary region. Ectopic breast tissue is subject to the same hormonal influences and risk of disease, including carcinoma, as anatomical breast. The incidence of carcinoma in ectopic tissue is approximately 0.3% of all breast cancers. Treatment should follow the same recommendations as those for breast tumors with the same tumor-node-metastasis stage. 相似文献
893.
894.
Since the introduction of laparoscopy and robotic surgery in gynecologic practice in the last several decades, use of these
minimally invasive surgical techniques has increased dramatically. The role of minimally invasive surgical techniques continues
to expand because they offer reduced intraoperative and postoperative complications, less intraoperative blood loss, and a
shorter postoperative recovery. Despite initial concerns about the use of minimally invasive surgery in gynecologic oncology,
this approach has been shown to be safe and effective in the management of uterine and cervical cancer, and minimally invasive
surgical management of these malignancies is now commonplace. Concerns remain regarding the use of minimally invasive surgery
for the staging and management of ovarian cancer, including concerns regarding the adequacy of abdominal exploration and staging
with minimally invasive approaches compared to traditional laparotomy and the risks and implications of intra-operative tumor
cyst rupture and port-site metastases. However, several case series, retrospective reviews, and case–control studies have
demonstrated that minimally invasive surgery is both safe and effective for the staging of borderline ovarian tumors and early-stage
epithelial ovarian cancer when performed by a trained gynecologic oncologist. Data to support the role of minimally invasive
surgery for advanced epithelial ovarian cancer are scant and use of minimally invasive surgery in this setting is not recommended. 相似文献
895.
Carlos Gómez-Martín Ángel Concha José María Corominas Tomás García-Caballero Elena García-García Mar Iglesias José Antonio López Santiago Ramón y Cajal Federico Rojo José Palacios Francisco Vera-Sempere Enrique Aranda Ramon Colomer Pilar García-Alfonso Pilar Garrido Fernando Rivera Fernando López-Ríos 《Clinical & translational oncology》2011,13(9):636-651
The identification of HER2 alterations in advanced gastric carcinomas is of critical importance in daily clinical practice as such neoplasms require specific treatment with trastuzumab. For these reasons, pathologists and oncologists with expertise in gastric carcinomas and HER2 testing from both organisations (SEAP and SEOM) have endeavoured to discuss and agree on national guidelines for HER2 testing in gastric carcinomas. These guidelines are based on the experience of those who participated in the discussions and also on experience published internationally. These agreed guidelines give the minimum requirements that a pathological anatomy laboratory must fulfil in order to guarantee adequate HER2 testing in daily practice. Any laboratories which do not meet the minimum standards set out in the guidelines must make every effort to achieve compliance. 相似文献
896.
Antn Barreiro‐Iglesias Verona Villar‐Cervio Ramn Anadn María Celina Rodicio 《Journal of anatomy》2009,215(6):601-610
Since its discovery, the possible corelease of classic neurotransmitters from neurons has received much attention. Colocalization of monoamines and amino acidergic neurotransmitters [mainly glutamate and dopamine (DA) or serotonin] in mammalian neurons has been reported. However, few studies have dealt with the colocalization of DA and γ‐aminobutyric acid (GABA) in neurons. With the aim of providing some insight into the colocalization of neurotransmitters during early vertebrate phylogeny, we studied GABA expression in dopaminergic neurons in the sea lamprey brain by using double‐immunofluorescence methods with anti‐DA and anti‐GABA antibodies. Different degrees of colocalization of DA and GABA were observed in different dopaminergic brain nuclei. A high degree of colocalization (GABA in at least 25% of DA‐immunoreactive neurons) was observed in populations of the caudal rhombencephalon, ventral isthmus, postoptic commissure nucleus, preoptic nucleus and in granule‐like cells of the olfactory bulb. A new DA‐immunoreactive striatal population that showed colocalization with GABA in about a quarter of its neurons was observed. In the periventricular hypothalamus, colocalization was observed in only a few cells, despite the abundance of DA‐ and GABA‐immunoreactive neurons, and no double‐labelled cells were observed in the paratubercular nucleus. The frequent colocalization of DA and GABA reveals that the dopaminergic populations of lampreys are more complex than previously reported. Double‐labelled fibres or terminals were observed in different brain regions, suggesting possible corelease of DA and GABA by these lamprey neurons. The present results suggest that colocalization of DA and GABA in neurons appeared early in vertebrate evolution. 相似文献
897.
Valdes R Bollela Manoel HC Gabarra Caetano da Costa Rita CP Lima 《BMC medical education》2009,9(1):30
Background
Medical programmes that implement problem-based learning (PBL) face several challenges when introducing this innovative learning method. PBL relies on small group as the foundation of study, and tutors facilitate learning by guiding the process rather than teaching the group. One of the major challenges is the use of strategies to assess students working in small groups. Self-, peer- and tutor-assessment are integral part of PBL tutorials and they're not easy to perform, especially for non experienced students and tutors. The undergraduate PBL medical programme was introduced in 2003, and after two years the curriculum committee decided to evaluate the tutorial assessment in the new program. 相似文献898.
Itziar Zazpe Ramón Estruch Estefanía Toledo Ana Sánchez-Taínta Dolores Corella Mónica Bulló Miquel Fiol Pablo Iglesias Enrique Gómez-Gracia Fernando Arós Emilio Ros Helmut Schröder Lluis Serra-Majem Xavier Pintó Rosa Lamuela-Raventós Valentina Ruiz-Gutiérrez Miguel Ángel Martínez-González 《European journal of nutrition》2010,49(2):91-99
Background
Determinants of dietary changes obtained with a nutritional intervention promoting the Mediterranean diet have been rarely evaluated.Aim
To identify predictors of higher success of an intervention aimed to increase adherence to a Mediterranean diet (MeDiet) in individuals at high cardiovascular risk participating in a trial for primary prevention of cardiovascular disease: the PREDIMED (PREvención con DIeta MEDiterránea) trial. Candidate predictors included demographic and socioeconomic characteristics, cardiovascular risk factors, and baseline dietary habits.Methods
A total of 1,048 asymptomatic subjects aged 55–80 years allocated to the active intervention groups (subjects in the control group were excluded). Participants’ characteristics were assessed at baseline among subjects. Dietary changes were evaluated after 12 months. Main outcome measures were: attained changes in five dietary goals: increases in (1) fruit consumption, (2) vegetable consumption, (3) monounsaturated fatty acid (MUFA)/saturated fatty acid (SFA) ratio, and decreases in (4) sweets and pastries consumption, (5) and meat consumption. Univariate and multivariate logistic regression analyses were used to examine associations between the candidate predictors and likelihood of attaining optimum dietary change (improved adherence to a MeDiet).Results
Among men, positive changes toward better compliance with the MeDiet were more frequent among non-diabetics, and among those with worse dietary habits at baseline (higher consumption of meat, higher SFA intake, lower consumption of fruit and vegetables). Among women, marital status (married) and worse baseline dietary habits (high in meats, low in fruits and vegetables) were the strongest predictors of success in improving adherence to the MeDiet.Conclusions
Some participant characteristics (marital status and baseline dietary habits) could contribute to predicting the likelihood of achieving dietary goals in interventions aimed to improve adherence to a MeDiet, and may be useful for promoting individualized long-term dietary changes and improving the effectiveness of dietary counseling. 相似文献899.
Alfredo Cano‐Garcinuño MD Isabel Mora‐Gandarillas MD Alberto Bercedo‐Sanz MD María Teresa Callén‐Blecua MD José Antonio Castillo‐Laita MD Irene Casares‐Alonso MD Dolors Forns‐Serrallonga PhD Eulàlia Tauler‐Toro MD Luz María Alonso‐Bernardo MD Águeda García‐Merino MD Isabel Moneo‐Hernández MD Olga Cortés‐Rico MD Ignacio Carvajal‐Urueña MD Juan José Morell‐Bernabé MD Itziar Martín‐Ibáñez MD Carmen Rosa Rodríguez‐Fernández‐Oliva MD María Teresa Asensi‐Monzó MD Carmen Fernández‐Carazo MD José Murcia‐García MD Catalina Durán‐Iglesias MD José Luis Montón‐Álvarez MD Begoña Domínguez‐Aurrecoechea MD Manuel Praena‐Crespo MD 《Pediatric pulmonology》2016,51(7):670-677
900.