全文获取类型
收费全文 | 2210篇 |
免费 | 133篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 100篇 |
妇产科学 | 87篇 |
基础医学 | 231篇 |
口腔科学 | 49篇 |
临床医学 | 171篇 |
内科学 | 589篇 |
皮肤病学 | 107篇 |
神经病学 | 150篇 |
特种医学 | 87篇 |
外国民族医学 | 1篇 |
外科学 | 347篇 |
综合类 | 21篇 |
预防医学 | 153篇 |
眼科学 | 26篇 |
药学 | 95篇 |
中国医学 | 8篇 |
肿瘤学 | 109篇 |
出版年
2023年 | 12篇 |
2022年 | 24篇 |
2021年 | 47篇 |
2020年 | 35篇 |
2019年 | 50篇 |
2018年 | 64篇 |
2017年 | 45篇 |
2016年 | 44篇 |
2015年 | 52篇 |
2014年 | 70篇 |
2013年 | 96篇 |
2012年 | 142篇 |
2011年 | 122篇 |
2010年 | 81篇 |
2009年 | 98篇 |
2008年 | 102篇 |
2007年 | 106篇 |
2006年 | 91篇 |
2005年 | 94篇 |
2004年 | 114篇 |
2003年 | 96篇 |
2002年 | 83篇 |
2001年 | 54篇 |
2000年 | 96篇 |
1999年 | 68篇 |
1998年 | 36篇 |
1997年 | 35篇 |
1996年 | 36篇 |
1995年 | 27篇 |
1994年 | 31篇 |
1993年 | 12篇 |
1992年 | 34篇 |
1991年 | 33篇 |
1990年 | 18篇 |
1989年 | 15篇 |
1988年 | 23篇 |
1987年 | 17篇 |
1986年 | 21篇 |
1985年 | 15篇 |
1984年 | 13篇 |
1983年 | 9篇 |
1982年 | 15篇 |
1981年 | 8篇 |
1979年 | 7篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1976年 | 7篇 |
1975年 | 8篇 |
1974年 | 7篇 |
1971年 | 8篇 |
排序方式: 共有2367条查询结果,搜索用时 0 毫秒
141.
CP Burren D Wanek S Mohan P Cohen J Guevara-Aguirre RG Rosenfeld 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(S428):185-191
Burren CP, Wanek D, Mohan S, Cohen P, Guevara-Aguirre J, Rosenfeld RG. Serum levels of insulin-like growth factor binding proteins in Ecuadorean children with growth hormone insensitivity. Acta Pædiatr 1999; Suppl 428: 185–91. Stockholm. ISSN 0803–5326
Although insulin-like growth factor binding proteins (IGFBPs) are known to be important modulators of the action of insulin-like growth factors (IGFs), regulation of their production in vivo is not completely understood. Serum concentrations of IGFBP-3, -4 and -5 and acid-labile subunit (ALS) were therefore examined in 20 children with growth hormone (GH) insensitivity before and after 6 months of therapy with recombinant human IGF-I (80 or 120 ug/kg twice daily). The IGFBP concentrations in these children were compared with those in 62 GH-deficient children receiving GH therapy for 3 months. Serum levels of IGFBP-3, -4 and -5 and ALS all increased significantly ( p < 0.0001) in GH-deficient children in response to GH therapy, whereas no significant increases occurred in the children with GH insensitivity. These findings indicate that GH is responsible for the regulation of serum levels of IGFBP-3, -4 and -5 and ALS, and that IGF-I does not directly regulate the concentrations of these circulating IGFBPs. □ Growth hormone, growth hormone insensitivity, insulin-like growth factor I, insulin-like growth factor binding protein 相似文献
Although insulin-like growth factor binding proteins (IGFBPs) are known to be important modulators of the action of insulin-like growth factors (IGFs), regulation of their production in vivo is not completely understood. Serum concentrations of IGFBP-3, -4 and -5 and acid-labile subunit (ALS) were therefore examined in 20 children with growth hormone (GH) insensitivity before and after 6 months of therapy with recombinant human IGF-I (80 or 120 ug/kg twice daily). The IGFBP concentrations in these children were compared with those in 62 GH-deficient children receiving GH therapy for 3 months. Serum levels of IGFBP-3, -4 and -5 and ALS all increased significantly ( p < 0.0001) in GH-deficient children in response to GH therapy, whereas no significant increases occurred in the children with GH insensitivity. These findings indicate that GH is responsible for the regulation of serum levels of IGFBP-3, -4 and -5 and ALS, and that IGF-I does not directly regulate the concentrations of these circulating IGFBPs. □ Growth hormone, growth hormone insensitivity, insulin-like growth factor I, insulin-like growth factor binding protein 相似文献
142.
I. Iglesias M. Martínez M. J. Muoz A. De La Torre J. M. Snchez‐Vizcaíno 《Transboundary and Emerging Diseases》2010,57(4):282-285
In October 2009, highly pathogenic avian influenza virus (HPAIV) was isolated for the first time in poultry in Spain. Sequencing analysis revealed that it was an H7N7 HPAIV. The progenitors of H7 HPAIV strains involved in recent European poultry outbreaks were simultaneously circulating in wild birds. The infected Spanish farm is located close to a reservoir abundant in wild birds. Epidemiological investigation found no links to other poultry holdings and those located in the control area were negative for AIV. Previous spatial risk analyses had identified the area where the infected holding is located to beat high relative risk for the introduction and presence of H5N1 HPAIV by wild birds. We suggest a risk‐based surveillance scheme that targets smaller geographical units but maintains the number of wild birds being sampled, as early detection of potentially pathogenic AIV is crucial in preventing spread to poultry. 相似文献
143.
144.
145.
146.
Dysphagia as the Sole Manifestation of Bilateral Strokes 总被引:2,自引:0,他引:2
Anthony Celifarco M.D. Gary Gerard M.D. David Faegenburg M.D. Robert Burakoff M.D. F.A.CP. 《The American journal of gastroenterology》1990,85(5):610-613
Dysphagia can be caused by a host of factors, most of which are structural or functional. However, despite extensive evaluations, a certain number of patients have unexplained dysphagia. We present an extremely unusual case whereby a patient with an acute left hemispheric cerebral vascular accident presents with dysphagia as his sole complaint and after extensive neurological, gastroenterological, and radiographic examinations is found to have cricopharyngeal dysfunction. The etiology of this defect was not at all clinically apparent and, ultimately, magnetic resonance imaging (MRI) was performed which revealed a chronic infarction of the right frontal lobe and a smaller acute infarction in the same location of the left. This case demonstrates that swallowing disorders may be the sole presentation of stroke and that, if extensive evaluations of such patients fail to yield an etiology, one must strongly consider MRI as a tool for diagnosis, even if a CT scan is negative. 相似文献
147.
Individualising gentamicin dosage regimens. A comparative review of selected models, data fitting methods and monitoring strategies. 总被引:2,自引:0,他引:2
The various components required for individualising clinical drug dosage regimens are reviewed, including a study of 3 types of fitting procedures, 2 types of gentamicin pharmacokinetic model and the utility of D-optimal times for obtaining serum gentamicin concentrations. The combination of the current Bayesian fitting procedure, the kslope pharmacokinetic model [in which the elimination rate constant (kel) can change from dose to dose with changing creatinine clearance] and the explicit measurement of the assay error pattern yielded predictions of future serum gentamicin concentrations which were (a) slightly better than those found using weighted nonlinear least squares; (b) somewhat better than those found with Bayesian fitting and a fixed-kel model; (c) better than those found using the traditional linear regression fitting procedure and a fixed kel model. D-Optimally timed pairs of concentrations also predicted future concentrations at least as well, and more cost effectively. 相似文献
148.
Nádia Valéria Mussi de Mira Isabel Louro Massaretto Cristina de Simone Carlos Iglesias Pascual Ursula Maria Lanfer Marquez 《Journal of food composition and analysis》2009,22(5):405-409
This study was conducted to evaluate the natural variability of total, extractable and non-extractable phenolics in pigmented and non-pigmented rice genotypes (Oryza sativa L.) and to estimate whether the contents and distribution of these compounds are typical for genotypes from indica and japonica subspecies. Twenty-one samples of commercial as well as new genotypes of brown rice, including seven pigmented genotypes were obtained from two Agronomic Institutes in South Brazil. Free and conjugated phenolics were extracted with ethanol, while bound phenolics were released by alkaline hydrolysis. Total phenolics were estimated in both fractions by the Folin–Ciocalteau method. Genotypes from japonica and indica non-pigmented subspecies were not statistically distinguishable from each other, but differences in phenolic contents were associated with pericarp color. Despite individual differences, total phenolics were four times higher in pigmented than in non-pigmented genotypes (4246 and 1073 mg ferulic acid equiv. kg?1, respectively). These high amounts were mostly due to the presence of extractable (free and conjugated) phenolics, which comprised up to 81% of total phenolics for pigmented genotypes. Non-extractable (bound) phenolics comprised 40% of total phenolics of non-pigmented rice genotypes while pigmented genotypes presented greater absolute amounts, but their contribution on total phenolics was small. 相似文献
149.
150.