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91.
E Chanudet H Ye J Ferry CM Bacon P Adam HK Müller‐Hermelink J Radford SA Pileri K Ichimura VP Collins RA Hamoudi AG Nicholson AC Wotherspoon PG Isaacson MQ Du 《The Journal of pathology》2009,217(3):420-430
The genetic basis of MALT lymphoma is largely unknown. Characteristic chromosomal translocations are frequently associated with gastric and pulmonary cases, but are rare at other sites. We compared the genetic profiles of 33 ocular adnexal and 25 pulmonary MALT lymphomas by 1 Mb array–comparative genomic hybridization (CGH) and revealed recurrent 6q23 losses and 6p21.2–6p22.1 gains exclusive to ocular cases. High‐resolution chromosome 6 tile‐path array–CGH identified NF‐κB inhibitor A20 as the target of 6q23.3 deletion and TNFA/B/C locus as a putative target of 6p21.2–22.1 gain. Interphase fluorescence in situ hybridization showed that A20 deletion occurred in MALT lymphoma of the ocular adnexa (8/42 = 19%), salivary gland (2/24 = 8%), thyroid (1/9 = 11%) and liver (1/2), but not in the lung (26), stomach (45) and skin (13). Homozygous deletion was observed in three cases. A20 deletion and TNFA/B/C gain were significantly associated (p < 0.001) and exclusively found in cases without characteristic translocation. In ocular cases, A20 deletion was associated with concurrent involvement of different adnexal tissues or extraocular sites at diagnosis (p = 0.007), a higher proportion of relapse (67% versus 37%) and a shorter relapse‐free survival (p = 0.033). A20 deletion and gain at TNFA/B/C locus may thus play an important role in the development of translocation‐negative MALT lymphoma. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献
92.
Richard VP De Villiers Savvas Andronikou Stephan Van de Westhuizen 《Journal of Medical Imaging and Radiation Oncology》2004,48(2):148-153
Tuberculosis (TB) remains the most common notifiable infectious disease in South Africa. The diagnosis of pulmonary TB in children is often very difficult because of the non‐specific radiological signs and inter‐observer variation in the interpretation of radiographs. The frontal high‐kilovolt (kV) radiograph has been used to assess the effect of TB adenopathy on the tracheobronchial tree and to detect endobronchial lesions. The aims of the present study were to assess the specificity and sensitivity of chest radiographs in the diagnosis of pulmonary TB and to assess whether the addition of the high‐kV radiograph affects these parameters. The study group consisted of paediatric patients suspected of having pulmonary TB over a 6‐year period. These patients had clinical, bacteriological and radiographic examinations. Radiographs were examined by one experienced radiologist in two sittings separated by a 6‐week interval. On the first sitting, only standard radiographs were examined and, on the second sitting, these were supplemented with high‐kV radiographs. Differences in the detection of each recognized radiological feature of pulmonary TB before and after the addition of the high‐kV film were analysed for statistical significance. The frequency of radiographic findings in our study compared favourably with other reports. No statistically significant differences for the detection of radiographic features consistent with pulmonary TB, or for the diagnosis of pulmonary TB, were demonstrated between the two sittings. Specificity increased from 74.4% to 86.6% with the addition of the high‐kV view and sensitivity remained constant at 38.8%. The present study does not support the routine use of the frontal high‐kV radiograph for the diagnosis of pulmonary TB. This paper also confirms the findings of others, that standard chest radiographs are a poor indicator of pulmonary TB in children. 相似文献
93.
Background: A significant number of soldiers suffer serious injuries or die in the process of demining and a protective device is necessary in such operations. 相似文献
94.
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96.
Meloxicam inhibits the growth of colorectal cancer cells 总被引:11,自引:1,他引:10
Goldman AP; Williams CS; Sheng H; Lamps LW; Williams VP; Pairet M; Morrow JD; DuBois RN 《Carcinogenesis》1998,19(12):2195-2199
Cyclooxygenase-2 has been reported to play an important role in colorectal
carcinogenesis. The effects of meloxicam (a COX-2 inhibitor) on the growth
of two colon cancer cell lines that express COX-2 (HCA-7 and Moser-S) and a
COX-2 negative cell line (HCT-116) were evaluated. The growth rate of these
cells was measured following treatment with meloxicam. HCA-7 and Moser-S
colony size were significantly reduced following treatment with meloxicam;
however, there was no significant change in HCT-116 colony size with
treatment. In vivo studies were performed to evaluate the effect of
meloxicam on the growth of HCA-7 cells when xenografted into nude mice. We
observed a 51% reduction in tumor size after 4 weeks of treatment. Analysis
of COX-1 and COX-2 protein levels in HCA-7 tumor lysates revealed a slight
decrease in COX- 2 expression levels in tumors taken from mice treated with
meloxicam and no detectable COX-1 expression. Here we report that meloxicam
significantly inhibited HCA-7 colony and tumor growth but had no effect on
the growth of the COX-2 negative HCT-116 cells.
相似文献
97.
Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification 总被引:1,自引:1,他引:1
98.
Chirayath Shiga Rappai Bhavani Nisha Vinayan K P Praveen VP Nair Sajitha 《International journal of diabetes in developing countries.》2021,41(3):518-521
International Journal of Diabetes in Developing Countries - This case series highlights rare reversible neurological complications encountered in two children who presented with diabetic... 相似文献
99.
100.
Suresh VS Attili AK Gulati VP Singh DV Varma M Rai Shyam Sundar 《BMC infectious diseases》2006,6(1):39