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In 1997, the United States Pharmacopeia (USP) established an Ad Hoc Outcomes/Cost Effectiveness Advisory Panel to consider the development of specifications for compiling, indexing, and evaluating outcomes research/cost-effectiveness literature on a disease-specific basis. Such a resource could be used to support pharmaceutical therapy choice decision making by a variety of potential users. The USP had developed a protype health outcomes and pharmacoeconomic annotated registry of the literature on the disease state, congestive heart failure. Other organizations have established and are marketing pharmacoeconomic and health outcome literature registries, with two examples being the HEED database (OHE-IFPMA Database Ltd.) and the University of York NHS Centre for Reviews and Dissemination (DARE).
OBJECTIVE: To share experiences and to identify the needs of decision makers for outcome/pharmacoeconomic information and to discuss whether they are being met by currently available literature sources. Decision makers include health care practitioners, managed care organizations, third party payers, industry and governments.
WORKSHOP FORMAT: The USP congestive heart failure protype literature registry will be described and compared to currently available pharmacoeconomic/outcome databases. Participants will share their assessment of the currently available abstracting service/databases and determine if there is a role for further developments.
DESIRED OUTCOME: To determine if there is a need for a collaborative approach among interested parties to make relevant health outcome/pharmacoeconomic information more accessible to the drug therapy decision makers in a format that is "user friendly." 相似文献
OBJECTIVE: To share experiences and to identify the needs of decision makers for outcome/pharmacoeconomic information and to discuss whether they are being met by currently available literature sources. Decision makers include health care practitioners, managed care organizations, third party payers, industry and governments.
WORKSHOP FORMAT: The USP congestive heart failure protype literature registry will be described and compared to currently available pharmacoeconomic/outcome databases. Participants will share their assessment of the currently available abstracting service/databases and determine if there is a role for further developments.
DESIRED OUTCOME: To determine if there is a need for a collaborative approach among interested parties to make relevant health outcome/pharmacoeconomic information more accessible to the drug therapy decision makers in a format that is "user friendly." 相似文献
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Total radical trapping antioxidant potential (TRAP) and exercise 总被引:1,自引:0,他引:1
Sharpe PC; Duly EB; MacAuley D; McCrum EE; Mulholland C; Stott G; Boreham CA; Kennedy G; Evans AE; Trinick TR 《QJM : monthly journal of the Association of Physicians》1996,89(3):223-228
The relationship between physical activity, physical fitness and total
radical trapping antioxidant potential (TRAP) was examined in the Northern
Ireland Health and Activity Survey. This was a cross-sectional population
study (n = 1600) using a two-stage probability sample of the population.
TRAP was calculated using the sum of the individual serum antioxidant
concentrations (urate, protein thiols, ascorbate, alpha tocopherol and
bilirubin) multiplied by their respective stoichiometric values. Physical
fitness was determined by estimation of VO2max by extrapolation from
submaximal oxygen uptake, and physical activity was recorded by
computer-assisted interview. Mean serum TRAP concentrations were
significantly higher in males (653 +/- 8.2 mumol/l, mean +/- SEM) compared
to females (564 +/- 8.0 mumol/l) (p < 0.0001). Both male and female
smokers had significantly lower TRAP values than non-smokers (males p <
0.0001, females p = 0.02). In females, there was a positive relationship of
TRAP with age (p < 0.001) and body mass index (p < 0.001) but a
negative relationship with physical fitness (p < 0.05). The known
beneficial effects of exercise and activity do not appear to be directly
mediated through increased antioxidant status.
相似文献
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Buttolph M 《Journal of medical biography》2010,18(4):198-204
John George Adami (1862-1926) qualified in medicine at Manchester and in 1892 was appointed professor of pathology at McGill University. At the invitation of the Royal College of Physicians (in London) he delivered the Croonian Lectures in 1917. He chose the title 'Adaptation and disease; the contribution of medical research to the study of evolution'. Adami believed that medical work had brought to light important facts about heredity that had not been communicated adequately to biological scientists. He used the lectures to describe this work, placing particular emphasis on his contention that acquired characters are inherited. At this time the medical audience at Adami's lectures would have been generally sympathetic to the idea that acquired characters can be inherited, though many leading British biologists were not sympathetic. Adami hoped that a concise review of the medical findings would persuade the biologists to his point of view or at least would be the starting point for a serious discussion of his evidence. However, the biologists were not persuaded and, although there were acrimonious personal exchanges, there was no scientific debate. 相似文献
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Taxiarchis Botsis Thomas Buttolph Michael D Nguyen Scott Winiecki Emily Jane Woo Robert Ball 《J Am Med Inform Assoc》2012,19(6):1011-1018