全文获取类型
收费全文 | 629篇 |
免费 | 33篇 |
国内免费 | 16篇 |
专业分类
儿科学 | 33篇 |
妇产科学 | 1篇 |
基础医学 | 66篇 |
口腔科学 | 8篇 |
临床医学 | 71篇 |
内科学 | 94篇 |
皮肤病学 | 79篇 |
神经病学 | 8篇 |
特种医学 | 101篇 |
外科学 | 83篇 |
综合类 | 33篇 |
预防医学 | 8篇 |
眼科学 | 3篇 |
药学 | 29篇 |
中国医学 | 1篇 |
肿瘤学 | 60篇 |
出版年
2022年 | 2篇 |
2021年 | 2篇 |
2020年 | 4篇 |
2019年 | 10篇 |
2018年 | 7篇 |
2017年 | 6篇 |
2016年 | 10篇 |
2015年 | 18篇 |
2014年 | 17篇 |
2013年 | 25篇 |
2012年 | 36篇 |
2011年 | 22篇 |
2010年 | 30篇 |
2009年 | 21篇 |
2008年 | 21篇 |
2007年 | 27篇 |
2006年 | 26篇 |
2005年 | 21篇 |
2004年 | 11篇 |
2003年 | 21篇 |
2002年 | 25篇 |
2001年 | 20篇 |
2000年 | 17篇 |
1999年 | 22篇 |
1998年 | 24篇 |
1997年 | 28篇 |
1996年 | 25篇 |
1995年 | 19篇 |
1994年 | 18篇 |
1993年 | 15篇 |
1992年 | 2篇 |
1991年 | 5篇 |
1990年 | 7篇 |
1989年 | 22篇 |
1988年 | 16篇 |
1987年 | 12篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1983年 | 8篇 |
1982年 | 3篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1975年 | 2篇 |
1925年 | 1篇 |
1924年 | 1篇 |
排序方式: 共有678条查询结果,搜索用时 520 毫秒
131.
132.
Hu SW Myskowski PL Papadopoulos EB Busam KJ 《The American Journal of dermatopathology》2012,34(6):e81-e83
The spectrum of clinical and histopathologic features associated with chronic graft-versus-host disease (GVHD) is broad, with recognized variants simulating scleroderma, lichen sclerosus, eosinophilic fasciitis, and de novo diffuse melanoderma. We report a case of a patient with multiple myeloma who presented approximately 1 year after his allogeneic hematopoietic stem cell transplantation with lesions of chronic lichenoid GVHD that harbored features of hypertrophic lupus erythematosus (LE) and that was initially mistaken for a superficial well-differentiated squamous cell carcinoma (SCC). However, in 4 years of follow-up, the patient failed to develop any evidence of cutaneous or systemic LE, actinic damage, or SCC, and the lesions cleared with topical and systemic treatments appropriate for chronic GVHD. For proper interpretation of the histologic findings of GVHD, it is important for the dermatopathologist to be aware of unusual manifestations. Knowledge of the occurrence of hypertrophic LE and familiarity with its histologic features is also important to avoid an erroneous diagnosis of SCC in immunosuppressed patients. 相似文献
133.
Statin therapy may prevent an excessive inflammatory response after cardiopulmonary bypass for cardiac surgery. In a recent
issue of Critical Care, Morgan and colleagues present data from a well-conducted systematic review and meta-analysis of randomised controlled trials
using inflammatory markers as primary outcome measure. They find that pre-operative statin therapy, compared with placebo,
may reduce various post-operative markers of systemic inflammation (IL-6, IL-8, C-reactive protein, tumour necrosis factor-alpha).
Their ability to make definitive conclusions is limited, however, by the suboptimal methodological quality of the primary
studies. Their review suggests that ICU researchers should focus on developing valid surrogate markers and use these to accurately
describe the mechanisms and effectiveness of novel therapies before proceeding to large pragmatic trials using mortality as
primary outcome. 相似文献
134.
Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma. 总被引:5,自引:0,他引:5
BACKGROUND: Immunohistochemical analysis of sentinel lymph nodes from patients with breast carcinoma and melanoma has been shown to increase the sensitivity for detecting lymph node metastases. To the authors' knowledge, this technique has not been described in patients with Merkel cell carcinoma. METHODS: Lymphatic mapping and sentinel lymph node biopsy was performed on 26 patients with Merkel cell carcinoma between 1997 and 1999. All sentinel lymph nodes were analyzed with conventional hematoxylin and eosin (H&E) staining and then analyzed with immunohistochemical staining to evaluate whether this additional technique would increase the number of patients found to have lymph node metastasis. RESULTS: The median age of the patients in the current study was 67 years and the median tumor size at the time of presentation was 2 cm. Lymph node metastases were identified in 5 of the 26 patients (19%). Three of these five lymph node positive patients were identified with H&E staining. The remaining two patients were identified only after immunohistochemical analysis. The median follow-up in this group of lymph node positive patients was 14 months, with 2 of the 5 lymph node positive patients developing a recurrence. The median follow-up in the 21 patients who were lymph node negative was 19 months, with only 1 patient having developed a recurrence at the time of last follow-up. CONCLUSIONS: Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma appears to increase the sensitivity of detecting clinically occult lymph node metastases. 相似文献
135.
136.
Hepatic arterial chemotherapy: role of angiography 总被引:2,自引:0,他引:2
Hepatic arterial infusion chemotherapy increases the hepatic concentration of chemotherapeutic agents without increasing systemic toxicity. Both percutaneous (most commonly left transbrachial) and surgical approaches are currently used for infusion catheter placement. Surgical catheter and pump placement has proved to be a reliable means of delivering drugs to the liver and has been commonly used for hepatic arterial chemotherapy for metastatic colorectal carcinoma. Meticulous angiographic evaluation of the hepatic vascular anatomy, its variations, and hemodynamics is necessary for correct catheter placement to achieve total liver perfusion without significant extrahepatic perfusion. Satisfactory hepatic perfusion should be documented before drug infusion. Hepatic arterial radionuclide flow imaging with technetium-99m-labeled macroaggregated serum albumin remains the most reliable means of assessing hepatic perfusion following catheter placement. Transcatheter techniques have been used to facilitate catheter placement, to prevent gastrointestinal drug toxicity, and to correct unsatisfactory perfusion following surgical catheter placement. 相似文献
137.
138.
139.
BACKGROUND: Telepathology is an emerging technology for remote pathology consultation and diagnosis. OBJECTIVE: To assess the diagnostic accuracy and utility of a dynamic telepathology system in the setting of Mohs surgery. METHODS: Using a dynamic telepathology system, a single dermatopathologist at a remote site assessed the following cases: (1) 50 fixed-tissue slides of basal and squamous cell carcinomas for pathologic diagnosis; (2) 40 frozen-section slides from Mohs surgery for the presence or absence of tumor; (3) 20 frozen-section slides from Mohs surgery for intraoperative consultation with the Mohs surgeon. All 110 slides were then randomly reviewed by the same dermatopathologist by conventional light microscopy. Telepathology and conventional light microscopy diagnoses were then compared. RESULTS: There was complete agreement between telepathology and conventional light microscopy diagnoses. CONCLUSION: Dynamic telepathology is a convenient, useful, and accurate system for remote diagnosis and consultation in the setting of Mohs surgery. 相似文献
140.
The absence of a vertebral pedicle, regardless of location, always merits careful consideration. There are a variety of disease states in addition to intrinsic mechanisms which may influence the development of the spine and hence potentiate pedicular absence. Each of these diseases or processes must be considered when confronted by a missing pedicle. This paper will identify and briefly discuss the most common conditions resulting in pedicular absence. 相似文献