全文获取类型
收费全文 | 1552篇 |
免费 | 130篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 52篇 |
妇产科学 | 28篇 |
基础医学 | 167篇 |
口腔科学 | 63篇 |
临床医学 | 195篇 |
内科学 | 460篇 |
皮肤病学 | 19篇 |
神经病学 | 39篇 |
特种医学 | 43篇 |
外科学 | 270篇 |
综合类 | 54篇 |
一般理论 | 5篇 |
预防医学 | 99篇 |
眼科学 | 22篇 |
药学 | 93篇 |
肿瘤学 | 69篇 |
出版年
2020年 | 15篇 |
2018年 | 18篇 |
2017年 | 16篇 |
2015年 | 15篇 |
2014年 | 17篇 |
2013年 | 39篇 |
2012年 | 39篇 |
2011年 | 60篇 |
2010年 | 22篇 |
2009年 | 34篇 |
2008年 | 54篇 |
2007年 | 44篇 |
2006年 | 42篇 |
2005年 | 55篇 |
2004年 | 51篇 |
2003年 | 30篇 |
2002年 | 40篇 |
2001年 | 36篇 |
2000年 | 32篇 |
1999年 | 43篇 |
1997年 | 19篇 |
1996年 | 16篇 |
1995年 | 20篇 |
1992年 | 32篇 |
1991年 | 38篇 |
1990年 | 28篇 |
1989年 | 22篇 |
1988年 | 38篇 |
1987年 | 30篇 |
1986年 | 27篇 |
1985年 | 29篇 |
1984年 | 19篇 |
1983年 | 21篇 |
1982年 | 16篇 |
1981年 | 21篇 |
1980年 | 26篇 |
1979年 | 44篇 |
1978年 | 31篇 |
1977年 | 28篇 |
1976年 | 22篇 |
1975年 | 28篇 |
1974年 | 35篇 |
1973年 | 42篇 |
1972年 | 29篇 |
1971年 | 34篇 |
1970年 | 24篇 |
1969年 | 34篇 |
1968年 | 38篇 |
1967年 | 26篇 |
1966年 | 27篇 |
排序方式: 共有1682条查询结果,搜索用时 0 毫秒
991.
Cotten SW Duncan DL Burch EA Seashore CJ Hammett-Stabler CA 《Clinical biochemistry》2012,45(9):605-609
ObjectivesThe results of newborn drug screening have far-reaching impact not only in healthcare, but also in the legal domain. Therefore, the accuracy of these results cannot be undervalued. When false positive cannabinoid (THC) screening results for this population were suspected at our institution, a multidisciplinary approach was initiated to evaluate the screening process for any pre-analytical or analytical sources of error or interference.Design and methodsMixtures of drug-free urine with various commercial products and materials that commonly contact newborns in our nursery were prepared and tested using the immunoassay screening methods in our laboratory. Additional commercial products were similarly tested; and when available, individual surfactants common to the interfering products were also evaluated.ResultsAddition of Head-to-Toe Baby Wash to drug-free urine produced a dose dependent measureable response in the THC immunoassay. Addition of other commercially available baby soaps gave similar results, and subsequent testing identified specific chemical surfactants that reacted with the THC immunoassay.ConclusionWe have identified commonly used soap and wash products used for newborn and infant care as potential causes of false positive THC screening results. Such results in this population can lead to involvement by social services or false child abuse allegations. Given these consequences, it is important for laboratories and providers to be aware of this potential source for false positive screening results and to consider confirmation before initiating interventions. Most importantly, we demonstrate the need for active involvement in the “total testing process,” as sources of error are not confined to the laboratory walls. 相似文献
992.
Necrotizing myositis is a severe and very rare streptococcal soft tissue infection involving the superficial fascia and muscle. Its clinical symptoms are nonspecific until the appearance of a fulminant clinical course with soft tissue destruction and septic shock. A high mortality and morbidity rate has been reported in the few cases over the last century. Despite several attempts to better define the different entities causing this necrotizing soft tissue infection, no clear treatment has been outlined. We present the case of a 47-year-old woman who had an acute necrotizing myositis after a stab wound. The diagnosis of necrotizing myositis was only established after surgical treatment with a pathology report. We reviewed the literature to highlight the clinical difficulty of a preoperative diagnosis and surgical treatment. 相似文献
993.
994.
995.
996.
Weber MH Burch S Buckley J Schmidt MH Fehlings MG Vrionis FD Fisher CG 《International journal of oncology》2011,38(1):5-12
Metastatic disease commonly occurs in the spine and incidence is likely to increase secondary to improved survival rates in many cancer patients. Despite published research on instability in patients with metastatic disease of the thoracolumbar spine, controversy exists regarding risk factors for instability and indications for surgical stabilization. The objective of this systematic review was to determine what defines instability and impending instability in patients with metastatic disease of the thoracic and lumbar spine. We systematically reviewed the medical literature in order to identify all the relevant studies concerning patients with metastatic involvement of T1-L5, in the domains of biomechanics, epidemiology, clinical issues, and radiographic parameters. Two independent observers performed study selection, methodological quality assessment, and data extraction in a blinded and objective manner for all the identified studies. We were then able to define the criteria to identify instability of the spine with metastases. A literature search and review identified 14 relevant, good quality studies for inclusion. The predictors of instability included increased tumor size, a larger cross-sectional area of bone defect, increased force of spinal loading, decreased bone density, posterior location of the tumor within the vertebrae, destruction of the costovertebral joint, pedicle destruction in the thoracolumbar spine, increased axial rigidity, and sagittal spinal deformity. Definitive conclusions cannot be reached due to lack of evidence. However, variables such as tumor size, magnitude of spinal loading, bone density, tumor location within the vertebrae and spine, and tumor type are risk factors for instability in spinal metastases. Improved clinical research methodology for this patient population is required. 相似文献
997.
Ajay Jain Bhawna Poonia Edward C. So Ravi Vyzasatya Erin E. Burch Henrik S. Olsen Emmanuel Y. Mérigeon David S. Block Xiaoyu Zhang Dan H. Schulze Nader N. Hanna William S. Twadell Harris G. Yfantis Siaw L. Chan Ling Cai Scott E. Strome 《European journal of cancer (Oxford, England : 1990)》2013,49(15):3344-3352
Tumour antigen targeted antibodies (mAbs) can induce natural killer (NK) cells to kill tumours through antibody dependent cellular cytotoxicity (ADCC) upon engagement of NK cell expressed FcγRIIIa. FcγRIIIa polymorphisms partially dictate the potency of the ADCC response. The high affinity FcγRIIIa-158-valine (V) polymorphism is associated with more potent ADCC response than the low affinity FcγRIIIa-158-phenylalanine (F) polymorphism. Because approximately 45% of patients are homozygous for the FcγRIIIa-158-F polymorphism (FF genotype), their ability to mount ADCC is impaired. We investigated whether a novel mAb capable of binding multiple antigen specific targets and engaging multiple low affinity FcγRIIIa receptors could further enhance ADCC against colon cancer in vitro. Specifically, we generated a novel anti-epidermal growth factor receptor (EGFR) antibody (termed a stradobody?) consisting of an unmodified Fab sequence and two Immunoglobulin G, subclass 1 (IgG1) Fc domains separated by an isoleucine zipper domain and the 12 amino-acid IgG2 hinge. The stradobody? framework induced multimerisation and was associated with increased binding to the EGFR and FcγRIIIa. From a functional perspective, when compared to an unmodified anti-EGFR mAb with a sequence identical to cetuximab (a commercially available anti-EGFR mAb), stradobodies? significantly enhanced ADCC. These effects were observed using both KRAS wild type HT29 and KRAS mutant SW480 colon cancer cells as targets, and by NK cells obtained from healthy donors and a cohort of patients with colon cancer. These data suggest that high avidity cross-linking of multiple tumour surface antigens and multiple NK cell associated FcγRIIIa molecules can enhance ADCC and partially overcome impaired ADCC by FF genotype individuals in vitro. 相似文献
998.
Akan Emin Chris A. Rogers Jayan Parameshwar Guy MacGowan Rhiannon Taylor Nizar Yonan Andre Simon Steven Tsui Stephan Schueler Nicholas R. Banner Nicholas Banner Peter Braidley Mike Burch Stephen Clark Dave Collett David Cromwell Kate Haire Jorge Mascaro Jayan Parameshwar Mark Petrie Andre Simon Steven Tsui Nizar Yonan Ms Katherine Collins Saleem Haj‐Yahia Guy MacGowan Steven Shaw Stephan Schueler John Townsend Rajamiyer Venkateswaran Ian Wilson Mike Winter Nizar Yonan 《European journal of heart failure》2013,15(10):1185-1193
999.
1000.