全文获取类型
收费全文 | 51457篇 |
免费 | 4352篇 |
国内免费 | 121篇 |
专业分类
耳鼻咽喉 | 490篇 |
儿科学 | 1431篇 |
妇产科学 | 1149篇 |
基础医学 | 7061篇 |
口腔科学 | 1152篇 |
临床医学 | 5187篇 |
内科学 | 10555篇 |
皮肤病学 | 756篇 |
神经病学 | 5436篇 |
特种医学 | 1838篇 |
外国民族医学 | 3篇 |
外科学 | 7161篇 |
综合类 | 1148篇 |
一般理论 | 82篇 |
预防医学 | 4825篇 |
眼科学 | 837篇 |
药学 | 3645篇 |
中国医学 | 52篇 |
肿瘤学 | 3122篇 |
出版年
2022年 | 291篇 |
2021年 | 671篇 |
2020年 | 411篇 |
2019年 | 696篇 |
2018年 | 871篇 |
2017年 | 620篇 |
2016年 | 730篇 |
2015年 | 848篇 |
2014年 | 1241篇 |
2013年 | 1939篇 |
2012年 | 2914篇 |
2011年 | 3074篇 |
2010年 | 1678篇 |
2009年 | 1593篇 |
2008年 | 2846篇 |
2007年 | 3128篇 |
2006年 | 3028篇 |
2005年 | 3115篇 |
2004年 | 2907篇 |
2003年 | 2683篇 |
2002年 | 2670篇 |
2001年 | 1038篇 |
2000年 | 960篇 |
1999年 | 963篇 |
1998年 | 656篇 |
1997年 | 626篇 |
1996年 | 569篇 |
1995年 | 567篇 |
1994年 | 449篇 |
1993年 | 446篇 |
1992年 | 757篇 |
1991年 | 752篇 |
1990年 | 679篇 |
1989年 | 742篇 |
1988年 | 610篇 |
1987年 | 602篇 |
1986年 | 612篇 |
1985年 | 539篇 |
1984年 | 534篇 |
1983年 | 539篇 |
1982年 | 445篇 |
1981年 | 433篇 |
1980年 | 354篇 |
1979年 | 379篇 |
1978年 | 330篇 |
1977年 | 256篇 |
1976年 | 276篇 |
1975年 | 218篇 |
1974年 | 262篇 |
1973年 | 260篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
ILR Genetics Consortium Emerging Risk Factors Collaboration Sarwar N Butterworth AS Freitag DF Gregson J Willeit P Gorman DN Gao P Saleheen D Rendon A Nelson CP Braund PS Hall AS Chasman DI Tybjærg-Hansen A Chambers JC Benjamin EJ Franks PW Clarke R Wilde AA Trip MD Steri M Witteman JC Qi L van der Schoot CE de Faire U Erdmann J Stringham HM Koenig W Rader DJ Melzer D Reich D Psaty BM Kleber ME Panagiotakos DB Willeit J Wennberg P Woodward M Adamovic S Rimm EB Meade TW Gillum RF Shaffer JA 《Lancet》2012,379(9822):1205-1213
992.
993.
Ramachandran R Wedatilake Y Coats C Walker F Elliott P Lee PJ Lachmann RH Murphy E 《Journal of inherited metabolic disease》2012,35(2):245-251
We present a review of our experience and pregnancy outcome in patients with GSD III managed by our centre. Between 1997 and
2010 there were 15 pregnancies in seven women with GSD III. Four women had GSD IIIb (nine pregnancies) and three GSD IIIa
(six pregnancies). There was a successful outcome in all 15 pregnancies with delivery of 15 liveborn infants. Four infants
were of low birthweight (<2nd centile) but all have developed normally apart from one with behavioural/psychiatric problems.
Three women had pre-existing cardiomyopathy prior to pregnancy. One of these women had deterioration of her cardiomyopathy
during pregnancy and again in the post-partum period. Women with GSD III do not seem to have any issues with fertility. Overall
the outcome of pregnancy for both mother and child is good. Care needs to be taken to avoid maternal hypoglycemia which may
be associated with intrauterine growth restriction and low birth weight. Cardiac function should be monitored carefully particularly
in those with pre-existing cardiomyopathy. 相似文献
994.
Zhang W Yang AL Liao J Li H Dong H Chung YT Bai H Matkowskyj KA Hammock BD Yang GY 《Digestive diseases and sciences》2012,57(10):2580-2591
Background
Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives dihydroxyeicosatrienoic acids. Thus, targeting sEH would be important for inflammation.Aims
To determine whether knockout or inhibition of sEH would attenuate the development of inflammatory bowel disease (IBD) in a mouse model of IBD in IL-10(?/?) mice.Methods
Either the small molecule sEH inhibitor trans/-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB) or sEH knockout mice were used in combination with IL-10(?/?) mice. t-AUCB was administered to mice in drinking fluid. Extensive histopathologic, immunochemical, and biochemical analyses were performed to evaluate effect of sEH inhibition or deficiency on chronic active inflammation and related mechanism in the bowel.Results
Compared to IL-10 (?/?) mice, sEH inhibition or sEH deficiency in IL-10(?/?) mice resulted in significantly lower incidence of active ulcer formation and transmural inflammation, along with a significant decrease in myeloperoxidase-labeled neutrophil infiltration in the inflamed bowel. The levels of IFN-γ, TNF-α, and MCP-1, as well VCAM-1 and NF-kB/IKK-α signals were significantly decreased as compared to control animals. Moreover, an eicosanoid profile analysis revealed a significant increase in the ratio of EETs/DHET and EpOME/DiOME, and a slightly down-regulation of inflammatory mediators LTB4 and 5-HETE.Conclusion
These results indicate that sEH gene deficiency or inhibition reduces inflammatory activities in the IL-10 (?/?) mouse model of IBD, and that sEH inhibitor could be a highly potential in the treatment of IBD. 相似文献995.
Win AK Walters RJ Buchanan DD Jenkins MA Sweet K Frankel WL de la Chapelle A McKeone DM Walsh MD Clendenning M Pearson SA Pavluk E Nagler B Hopper JL Gattas MR Goldblatt J George J Suthers GK Phillips KD Woodall S Arnold J Tucker K Field M Greening S Gallinger S Aronson M Perrier R Woods MO Green JS Walker N Rosty C Parry S Young JP 《The American journal of gastroenterology》2012,107(5):770-778
996.
Chakravarty EF Hubert HB Krishnan E Bruce BB Lingala VB Fries JF 《The American journal of medicine》2012,125(2):190-197
BackgroundAssociations between modifiable health risk factors during middle age with disability and mortality in later life are critical to maximizing longevity while preserving function. Positive health effects of maintenance of normal weight, routine exercise, and nonsmoking are known for the short and intermediate term. We studied the effects of these risk factors into advanced age.MethodsA cohort of 2327 college alumnae aged 60 years or more was followed annually (1986-2005) by questionnaires addressing health risk factors, history, and Health Assessment Questionnaire disability. Mortality data were ascertained from the National Death Index. Low-, medium-, and high-risk groups were created on the basis of the number (0, 1, ≥2) of health risk factors (overweight, smoking, inactivity) at baseline. Disability and mortality for each group were estimated from unadjusted data and regression analyses. Multivariable survival analyses estimated time to disability or death.ResultsThe medium- and high-risk groups had higher disability than the low-risk group throughout the study (P < .001). Low-risk subjects had onset of moderate disability delayed 8.3 years compared with high-risk subjects. Mortality rates were higher in the high-risk group (384 vs 247 per 10,000 person-years). Multivariable survival analyses showed the number of risk factors to be associated with cumulative disability and increased mortality.ConclusionSeniors with fewer behavioral risk factors during middle age have lower disability and improved survival. These data document that the associations of lifestyle risk factors on health continue into the ninth decade. 相似文献
997.
998.
999.
Dentistry is rapidly entering a new era of evidence-based practice, and society is demanding prevention and treatment that has been proven to be effective in terms of meaningful health outcomes. Practitioners, individual patients and the public need randomized controlled trials because they provide the highest level of scientific evidence to change clinical practice and inform public health policy. Well-designed randomized controlled trials are conceptually simple but deceptively complex to design, implement and translate into clinical practice. Randomized controlled trials are fundamentally different from observational clinical research because they randomly assign volunteers to receive test or control interventions, they are prospective and the success of the test intervention is based on a meaningful clinical outcome that is specified before the trial begins. To be successful, randomized controlled trials must be carefully designed and powered to answer a specific question that will be generalizable to the population under study. Randomized controlled trials can be designed to evaluate efficacy, effectiveness, superiority, equivalence or noninferiority. Prominent issues and challenges in designing and conducting randomized controlled trials include carefully defining enrollment criteria, establishing an organizational infrastructure, use of a data-coordinating center, developing a manual of procedures, obtaining informed consent, recruiting and ensuring the safety of volunteer subjects, ensuring data quality, analysis and publication of trial outcomes, and translating results into clinical practice. 相似文献
1000.
Treacher Collins syndrome is a congenital syndrome with characteristic craniofacial malformations, which are well described in the literature. However, the presence of cervical spine dysmorphology in this syndrome has been minimally described. This study reviews cervical spine radiographs of 40 patients with Treacher Collins syndrome. In this sample, 7 of 40 patients displayed cervical spine anomalies, with 3 of these patients displaying multiple cervical spine anomalies. The patterns of spinal anomalies were variable, suggesting that the underlying genetic mutation has variable expressivity in cervical spine development as it does elsewhere in the craniofacial skeleton. 相似文献