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91.
92.
Cavalcanti AM Brito AM Salustiano DM Lima KO Silva SP Lacerda HR 《The Brazilian journal of infectious diseases》2012,16(2):157-163
The BED capture enzyme immunoassay test makes it possible to determine whether individuals were recently infected with HIV.ObjectiveIn this study, the overall HIV and recent infections prevalences were determined at five Voluntary Counseling and Testing (VCT) centers, in the Metropolitan Region of Recife, Northeastern of Brazil.Material and methodsA cross-sectional study was conducted among users of five VCTs in the metropolitan region of Recife between July 2007 and April 2009. Out of the individuals who tested positive for HIV, 169 were analyzed to assess the prevalence of recent infection by means of the BED-CEIA (BED-Calypte®).ResultsOut of 46,696 individuals tested 916 (1.96%) turned out positive for HIV infection The highest prevalence was in Recife (3.9%). The prevalence was higher among males (3.93%), and men who have sex with men (MSM) (12.4%). The frequency of recent infections among the 169 subjects evaluated was 23.7%. Recent infections were more common among individuals under 25 years of age. There was slight predominance of men and higher frequency of heterosexuals in both groups, but still a significant portion of MSM (33%). Subtype B predominated, followed by a high proportion of subtype F.ConclusionsRecent infection occurs mainly among young individuals and heterosexuals, despite a significant proportion of recent infection among MSM. These results suggest that preventive actions aimed at the MSM community remains a challenge and efforts focusing this group should continue to be a priority. 相似文献
93.
Monica Sarto Piccolo Alfredo Gragnani Ricardo Piccolo Daher Marco de Tubino Scanavino Maria José de Brito Lydia Masako Ferreira 《Burns : journal of the International Society for Burn Injuries》2013
In measuring the quality of life of burn victims, it is essential that we find reliable and valid means. The Burn Sexuality Questionnaire (BSQ) is a specific instrument that assesses sexuality in the context of quality of life of burn victims. We set out to translate, validate and culturally adapt the BSQ into Brazilian Portuguese. The Portuguese version was applied to 80 patients. After translation, cultural adaptation was performed with 30 patients. We also tested the final version for reliability in 20 patients, and for face, content and construct validities in 30 patients, according to standard procedures. Total Cronbach's alpha was 0.87. Pearson's correlation was significant between scores for different time points. Construct validity was demonstrated with the correlation of the BSQ with the Burn Specific Health Scale – Revised (BSHS-R) questionnaire. It showed significant correlation between the BSQ social comfort domain and the BSHS-R affect and body image (p = 0.025), simple function ability (p = 0.008), work (p = 0.016) and treatment (p = 0.037) domains. This cultural adaptation of the BSQ suggests that it is a reliable tool and has construct validity for the social comfort domain. There is still need for a better-structured tool that could possibly evaluate functional and psychological aspects of sexuality, because one could easily overlook the psychosocial aspects of patients with major, complex burns. 相似文献
94.
de Menezes AM de Souza GF Gomes AS de Carvalho Leitão RF Ribeiro Rde A de Oliveira MG de Castro Brito GA 《Journal of periodontology》2012,83(4):514-521
Background: S‐nitrosoglutathione (GSNO) is a nitric oxide donor that may exert antioxidant, anti‐inflammatory, and microbicidal actions and is thus a potential drug for the topical treatment of periodontitis. In this study, the effect of intragingival injections of GSNO‐containing polyvinylpyrrolidone (PVP) formulations is evaluated in a rat model of periodontitis. Methods: Periodontal disease was induced by placing a sterilized nylon (000) thread ligature around the cervix of the second left upper molar of the animals, which received intragingival injections of PVP; saline; or PVP/GSNO solutions which corresponded to GSNO doses of 25, 100, and 500 nmol; 1 hour before periodontitis induction, and thereafter, daily for 11 days. Results: PVP/GSNO formulations at doses of 25 and/or 100, but not 500 nmol caused significant inhibition of alveolar bone loss, increase of bone alkaline phosphatase, decrease of myeloperoxidase activity, as well as significant reduction of inflammatory and oxidative stress markers when compared to saline and PVP groups. These effects were also associated with a decrease of matrix metalloproteinases 1 and 8, inducible nitric oxide synthase, and nuclear factor‐κB immunostaining in the periodontium. Conclusion: Local intragingival injections of GSNO reduces inflammation and bone loss in experimental periodontal disease. 相似文献
95.
96.
Lívia M. Paranaíba Sibele N. de Aquino Andreia Bufalino Hercílio Martelli-Júnior Edgard Graner Luciano A. Brito Maria R. Passos-Bueno Ricardo-D. Coletta Mário S. Swerts 《Medicina oral, patología oral y cirugía bucal》2013,18(3):e414-e420
Background and Objective: Nonsyndromic cleft lip and/or palate (NSCL/P) is a complex disease associated with both genetic and environmental factors. One strategy for identifying of possible NSCL/P genetic causes is to evaluate polymorphic variants in genes involved in the craniofacial development.
Design: We carried out a case-control analysis of 13 single nucleotide polymorphisms in 9 genes related to craniofacial development, including TBX1, PVRL1, MID1, RUNX2, TP63, TGF?3, MSX1, MYH9 and JAG2, in 367 patients with NSCL/P and 413 unaffected controls from Brazil to determine their association with NSCL/P.
Results: Four out of 13 polymorphisms (rs28649236 and rs4819522 of TBX1, rs7940667 of PVRL1 and rs1057744 of JAG2) were presented in our population. Comparisons of allele and genotype frequencies revealed that the G variant allele and the AG/GG genotypes of TBX1 rs28649236 occurred in a frequency significantly higher in controls than in the NSCL/P group (OR: 0.41; 95% CI: 0.25-0.67; p=0.0002). The frequencies of rs4819522, rs7940667 and rs1057744 minor alleles and genotypes were similar between control and NSCL/P group, without significant differences. No significant associations among cleft types and polymorphisms were observed.
Conclusion: The study suggests for the first time evidences to an association of the G allele of TBX1 rs28649236 polymorphism and NSCL/P.
Key words:Cleft lip, cleft palate, polymorphism, genetic. 相似文献
97.
98.
Neuroprotective Effects of Sulphated Agaran from Marine Alga Gracilaria cornea in Rat 6‐Hydroxydopamine Parkinson's Disease Model: Behavioural,Neurochemical and Transcriptional Alterations 下载免费PDF全文
Ricardo Basto Souza Annyta Fernandes Frota Rayane Siqueira Sousa Nayara Araújo Cezario Tarcizio Brito Santos Luziana Mara Frota Souza Chistiane Oliveira Coura Valdécio Silvano Monteiro Gerardo Cristino Filho Silvânia Maria Mendes Vasconcelos Rodrigo Maranguape Silva da Cunha Lissiana Magna Vasconcelos Aguiar Norma Maria Barros Benevides 《Basic & clinical pharmacology & toxicology》2017,120(2):159-170
99.
Monalisa Cesarino Gomes Matheus França Perazzo Erick Tássio Neves Maria Betânia Lins Dantas Siqueira Edja Maria Melo de Brito Costa Ane Polline Lacerda Protasio Adriana Freitas Lins Pimentel Silva Kátia Virgínia Guerra Botelho Ana Flávia Granville-Garcia 《Zeitschrift fur Gesundheitswissenschaften》2018,26(5):587-594