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Escobedo-Meléndez G Fierro NA Roman S Maldonado-González M Zepeda-Carrillo E Panduro A 《Annals of hepatology》2012,11(2):194-201
Introduction. Viral hepatitis in children is a major public health problem worldwide.Aim. To evaluate the prevalence of serological markers for hepatitis A, B and C infections in Mexican children diagnosed with hepatitis during a five-year period.Material and methods. A total of 31,818 children admitted to a tertiary level hospital in Mexico from 2005 to 2009 were evaluated for hepatitis.Results. Hepatitis was found in 215 (0.7%) of the children. Serum samples from hepatitis-positive children were screened for anti-HAV IgM, HBsAg, total anti-HBc and anti-HCV. HAV was the leading cause of viral hepatitis (81%), followed by HBV and HCV (3.1 and 2%, respectively), whereas no serological marker was observed in 13.9% of the analyzed samples. Furthermore, when children were categorized by age, a significant increase in anti-HAV detection was observed in school-aged children (7-11 years old) (p < 0.001) and a reduction in adolescents (12-15 years old).Conclusion. In conclusion, hepatitis A is the most prevalent viral hepatitis infection detected in children, followed by HBV and HCV. In addition, the high percentage of hepatitis infections without a known etiological agent and the serological test limitations require the detection of occult HBV, HCV and hepatitis E infections. The age-dependent vulnerability of groups with HAV infections emphasizes the importance of HAV vaccination in young children in Mexico. 相似文献
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Fierro B Giglia G Palermo A Pecoraro C Scalia S Brighina F 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2007,176(3):440-447
Clinical observations and data from animal experiments point to a physiological facilitatory influence of the deep cerebellar
structures on the motor system through the cerebello-thalamo-cortical pathways. The aim of the present study was to explore
the long-term effects of low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) over the cerebellum on short
intracortical inhibition (SICI) and facilitation (ICF) of the motor cortex in normal subjects. Eight healthy subjects (mean
age 26.9 ± 3.1) underwent 1 Hz frequency rTMS delivered on the right cerebellar hemisphere. Before and after cerebellar rTMS,
SICI and ICF were assessed in the motor cortex contralateral to the stimulated cerebellar hemisphere by means of a paired
pulse paradigm with a conditioning subthreshold stimulus set to 80% of the motor threshold (MT) followed by a testing stimulus
at 120% of MT intensity. Five different interstimulus intervals (ISIs) were used to assess SICI (2 and 4 ms) and ICF (7, 10
and 15 ms). Amplitude of the responses was expressed as the percentage of motor evoked potential (MEP) to test stimulus alone.
Results showed a significant decrease of ICF at 10 ms ISI that persisted up to 20 min after cerebellar rTMS. This was the
only significant modulatory effect of cerebellar stimulation on intracortical motor excitability A suppressive effect of the
low-frequency TMS on Purkinje cells could be supposed, even if, the lack of effects on other facilitatory ISIs, stands for
more complex modulatory effects of rTMS over cerebellum. The study is a further demonstration that rTMS over the cerebellum
induces a long-lasting modulatory effect on the excitability of the interconnected motor area. 相似文献
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Rota E. Testa L. Di Brigida G. Agosti S. Rovere M. E. Risso R. Morelli N. 《Journal of thrombosis and thrombolysis》2020,50(3):732-738
Journal of Thrombosis and Thrombolysis - Approximately 1–2% of patients with non-valvular atrial fibrillation have an acute ischemic stroke (AIS) while on direct oral anticoagulant (DOAC)... 相似文献
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Iara Buriola Trevisan Ubiratan de Paula Santos Marceli Rocha Leite Aline Duarte Ferreira Bruna Spolador de Alencar Silva Ana Paula Coelho Figueira Freire Gabriel Faustino Santa Brigida Ercy Mara Cipulo Ramos Dionei Ramos 《Revista brasileira de otorrinolaringologia (English ed.)》2019,85(3):337-343
IntroductionBurnt sugarcane harvesting requires intense physical exertion in an environment of high temperature and exposure to particulate matter.ObjectiveTo evaluate the effects of burnt sugarcane harvesting on rhinitis symptoms and inflammatory markers in sugarcane workers.MethodsA total of 32 male sugarcane workers were evaluated with questionnaire for rhinitis symptoms, and for inflammatory markers on peripheral blood and nasal lavage, in the non-harvesting, and 3 and 6 months into the sugarcane harvesting period. Weather data and particulate matter fine concentrations were measured in the same day.ResultsThe particulate matter concentrations in sugarcane harvesting were 27 (23–33 μg/m3), 112 (96–122 μg/m3), and 63 (17–263 μg/m3); 24 h temperatures were 32.6 (25.4–37.4 °C), 32.3 (26.7–36.7 °C) and 29.7 (24.1–34.0 °C) and relative humidities were 45.4 (35.0–59.7%), 47.9 (39.1–63.0%), and 59.9 (34.7–63.2%) in the non-harvesting period, three and 6 months of the harvesting period. The age was 37.4 ± 10.9 years. The prevalence of rhinitis symptoms was significantly higher at 3 months of the harvesting period (53.4%), compared to non-harvesting period (26.7%; p = 0.039) and at 6 months into the harvesting period (20%; p = 0.006). Concentrations of interleukin 6 (IL-6) in nasal lavage increased after 3 months of the harvesting period compared to the non-harvesting period (p = 0.012). The presence of rhinitis symptoms, after 3 months of the harvesting period, was directly associated with blood eosinophils and inversely associated with neutrophils.ConclusionsAfter 3 months of work in burnt sugarcane harvesting the prevalence of rhinitis symptoms and IL-6 in nasal lavage increased. Furthermore, eosinophil counts were directly associated with the rhinitis symptoms in the period of higher concentration of particulate matter. 相似文献
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Zegarra-Chapo?an Roberto Bonadonna Lily Victoria Yuen Courtney M. Martina-Chávez Martha Brigida Zeladita-Huaman Jhon 《贫困所致传染病(英文)》2021,10(3):26-33
Background::Tuberculosis (TB) prevention through the use of preventive treatment is a critical activity in the elimination of TB. In multiple settings, limited ... 相似文献