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When faced with the management of the patient on intensive care with acute kidney injury, the clinician has various choices
to consider. The conventional therapy, where appropriate, is renal replacement therapy. This technique used to be relatively
straightforward but now a relative feast of alternatives is available, not least in choice of buffer and anticoagulant. Two
recent studies add to the growing body of literature concerning alternative anticoagulant regimes, and one in particular should
lead to a change in practice for many of us. We also review some new studies on biomarkers in the diagnosis of acute kidney
injury as well as add yet another nail in the coffin for loop diuretics in the therapy of acute kidney injury. 相似文献
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Programmed cell death, also known as apoptosis, is frequently initiated when cells are deprived of specific trophic factors. To investigate if accelerated apoptosis contributes to the pathogenesis of Diamond- Blackfan anemia (DBA), a rare pure red blood cell aplasia of childhood, we studied the effect of erythropoietin (epo) deprivation on erythroid progenitors and precursors from the bone marrow of DBA patients as compared with hematologically normal controls. Apoptosis in response to epo deprivation was evaluated by enumeration of colony-forming unit- erythroid (CFU-E)- and burst-forming unit-erythroid (BFU-E)-derived colonies in plasma clot semisolid culture and by the identification of typical DNA oligosomes by gel electrophoresis from marrow mononuclear cells in liquid culture. In all DBA patients there was a marked decrease in CFU-E- and BFU-E-derived colony formation compared with normal controls at comparable time points of epo deprivation, with a complete loss of CFU-E-derived colonies in semisolid culture by 9 hours of epo deprivation versus 48 hours in controls. The BFU-E-derived colony response to epo deprivation displayed a similar pattern of decrement. Apoptotic changes assessed by the presence of characteristic DNA fragmentation began in the absence of epo deprivation and were readily detected within 3 hours of epo deprivation in DBA cultures versus 9 hours in controls. We conclude that DBA is characterized by accelerated apoptosis as measured by the loss of erythroid progenitor clonogenicity and increased progenitor and precursor DNA fragmentation leading to the formation of characteristic oligosomes, consistent with an intrinsic erythroid-progenitor defect in which increased sensitivity to epo deprivation results in erythroid failure. 相似文献
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胰岛素样生长因子与胎儿宫内发育迟缓 总被引:1,自引:0,他引:1
0 引言 胎儿宫内发育迟缓(IUGR)是指出生体质量小于其孕龄平均体质量的第10百分位者,或者小于其平均体质量的两个标准差者.发病率约为3%~4%.IUGR是围产儿死亡的重要原因之一,新生儿期及远期发病率明显增高.在儿童期比正常儿体格和智力发育均落后.还有研究提示IUGR和成年期发生糖尿病及心血管病有因果联系[1].鉴于以上原因,IUGR的病因探讨越来越受到人们的重视,尤其是对IUGR内分泌方面的研究也越来越深入.本文着重综述近年来胰岛素样生长因子(insulinlikegrowthfact… 相似文献
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