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91.
Alfonso Pérez-Parra Patricia Muñoz Jesús Guinea Pablo Martín-Rabadán María Guembe Emilio Bouza 《Intensive care medicine》2009,35(4):707-712
Purpose To assess the influence of antifungal therapy on the outcome of non-candidemic adult patients with central vascular catheter
(CVC) tips colonized by Candida species.
Methods A retrospective analysis of the outcome of patients with Candida colonization of their CVC tip and no concurrent candidemia was made over a 4-year period. Patients who either died or developed
candidemia-invasive candidiasis (poor outcome) were compared with those who improved.
Results We finally included 58 patients for analysis. Almost all (91.4%) had to be admitted to the ICU during their hospital stay.
Independent predictors for outcome were a McCabe and Jackson score corresponding to ultimately fatal underlying disease [odds
ratio (OR) 11.98; 95% confidence interval (CI), 1.37–104.97; P = 0.02], and maximum severity corresponding to severe sepsis, septic shock or multiorgan failure (OR: 6.16, CI 95%: 1.00–37.93;
P = 0.05). We were unable to demonstrate that antifungal therapy was an independent variable influencing outcome (OR 0.82;
95% CI, 0.27–2.47; P = 0.73).
Conclusions Our data suggest that, in non-neutropenic critically ill patients with no concomitant candidemia and with CVC tips colonized
by Candida, antifungal therapy does not seem to have a significant influence on clinical outcome.
This article is discussed in the editorial available at: doi:. 相似文献
92.
93.
The group G streptococcus may be a more common human pathogen than previously recognized. A case of group G streptococcal endocarditis is reported and the 11 cases reported previously are reviewed. Group G endocarditis may have significant clinical and prognostic differences from endocarditis caused by the more commonly identified viridans or group D streptococci. Routine serologic grouping of beta-hemolytic streptococcal isolates from serious infections is warranted. 相似文献
94.
S Moreno R Martinez C Barros J Gonzalez-Lahoz E Garcia-Delgado E Bouza 《AIDS (London, England)》1991,5(8):967-970
Pneumonia caused by common pyogenic bacteria occurs frequently in HIV-infected patients. Its clinical presentation has been described as being similar to that seen in non-immunosuppressed hosts but clearly different to that of opportunistic pneumonias. An atypical presentation has rarely been seen. In a 10-month period, we saw 12 HIV-infected patients who presented with Haemophilus influenzae pneumonia which was clinically and radiologically indistinguishable from Pneumocystis carinii pneumonia. Ten of the patients were intravenous drug users and were in different stages of HIV disease. The clinical picture was characterized by a prolonged course (median 4 weeks), non-productive cough, dyspnoea, and absence of findings usually present in bacterial pneumonia. Laboratory data frequently showed absence of leukocytosis, increased lactate dehydrogenase levels, hypoxaemia, and decreased CD4+ cell counts. All presented with interstitial or mixed bilateral infiltrates. Resistance to ampicillin and trimethoprim-sulphamethoxazole were each found in seven cases. Eleven patients were cured with antibiotic therapy, although five relapsed. H. influenzae pneumonia should be considered in HIV-infected patients who present with pulmonary symptoms and bilateral infiltrates of subacute or chronic onset. Clinical resolution of pneumonia is the usual outcome, but recurrences of infection are frequent. 相似文献
95.
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97.
Fernanda Sislema-Egas María Jesús Ruiz-Serrano Emilio Bouza Darío García-de-Viedma 《Journal of clinical microbiology》2013,51(12):4230-4233
Mycobacterium tuberculosis is currently genotyped using mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) typing, although the high cost of this technique restricts its implementation in resource-limited settings. We designed a MIRU-VNTR format, MLP3 (MIRU-VNTR length polymorphism triplex), that is based on the qualitative comparison of 5 nonfluorescent 3-band fingerprints in conventional electrophoresis and minimizes costs and technical demands. MLP3 successfully resolved cross-contamination alerts, discriminated reinfections from reactivations, clarified suspected microepidemics, and tracked transmission events of high epidemiological interest. 相似文献
98.
Efficacy and safety of balloon kyphoplasty in the treatment of vertebral compression fractures: a systematic review 总被引:17,自引:2,他引:15
Carmen Bouza Teresa López Angeles Magro Lourdes Navalpotro José María Amate 《European spine journal》2006,15(7):1050-1067
The aim of this study is to evaluate the efficacy and safety of balloon kyphoplasty (BK) in the management of vertebral compression fractures (VCFs). This study is based on a systematic review of the literature (until October 2004) and meta-analysis of clinical studies assessing the efficacy and safety of BK in the treatment of VCFs. Estimates of effect were based on a random effects model. Meta-regression analyses were carried out where required. A total of 26 studies met the inclusion criteria. Although studies displayed considerable methodological limitations, the results of the clinical series indicate significant improvements in pain intensity, vertebral height, sagittal alignment, functional capacity, and quality of life. Compared with conventional medical management, BK afforded significant improvement in pain intensity and mobility. Likewise, a significant reduction was observed in vertebral collapse, kyphotic deformity, the development of new vertebral fractures, and hospital stay. Compared with vertebroplasty, the technique reduced the loss of height and the degree of kyphotic deformity, and afforded a significantly lower leakage rate—with no differences in relation to other variables. Regarding adverse effects, leakage affected 7% of all levels treated, while complications were recorded in 2% of the patients, and new vertebral fractures in 16%. The available evidence suggests that BK can be effective and safe in application to VCFs. However, existing studies evince substantial methodological limitations and relatively short follow-up periods. Better clinical research is required to determine the capacity of BK to avoid the functional and physiological sequelae of VCFs and to define the true role of the technique among the existing therapeutic options. 相似文献
99.
Guembe M Pérez-Parra A Gómez E Sánchez-Luna M Bustinza A Zamora E Carrillo-álvarez A Cuenca A Padilla B Martín-Rabadán P Bouza E;on behalf of the GEIDI Study Group 《European journal of clinical microbiology & infectious diseases》2012,31(10):2799-2808
Information on the impact of care bundles has been mainly acquired in adult intensive care units (ICUs). However, specific data for educational programs are scarce. Our objective was to analyze the impact of an educational program on the knowledge and prevention of catheter-related bloodstream infection (CRBSI) in two pediatric intensive care units (P-ICUs). A prospective study was carried out at a large teaching institution in Madrid, Spain. Healthcare workers' (HCWs) knowledge of guidelines for the prevention of CRBSI was assessed before and after the educational program using a questionnaire covering 12 issues. A 20-min program was offered to all HCWs on each ICU shift. The incidence density of CRBSI was assessed before, during, and after the educational program. A total of 174 questionnaires were completed by HCWs from both the neonatal ICU (N-ICU) and the P-ICU before the intervention and 54 were completed after the intervention (120 participants were not present during this period). The incidence density of CRBSI before, during, and after the intervention was 6.2, 5.2, and 9.3 in the N-ICU and 2.2, 3.1, and 2.9 in the P-ICU (p?>?0.05). A single 20-min educational intervention on the prevention of CRBSI significantly improved HCWs' knowledge, but was not enough to reduce the incidence density of CRBSI. 相似文献
100.