全文获取类型
收费全文 | 1157篇 |
免费 | 62篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 47篇 |
妇产科学 | 20篇 |
基础医学 | 106篇 |
口腔科学 | 33篇 |
临床医学 | 156篇 |
内科学 | 273篇 |
皮肤病学 | 46篇 |
神经病学 | 96篇 |
特种医学 | 145篇 |
外科学 | 50篇 |
综合类 | 71篇 |
预防医学 | 57篇 |
眼科学 | 26篇 |
药学 | 69篇 |
中国医学 | 1篇 |
肿瘤学 | 42篇 |
出版年
2022年 | 6篇 |
2021年 | 10篇 |
2020年 | 8篇 |
2019年 | 7篇 |
2018年 | 10篇 |
2017年 | 10篇 |
2016年 | 15篇 |
2015年 | 19篇 |
2014年 | 26篇 |
2013年 | 70篇 |
2012年 | 33篇 |
2011年 | 30篇 |
2010年 | 38篇 |
2009年 | 43篇 |
2008年 | 29篇 |
2007年 | 48篇 |
2006年 | 33篇 |
2005年 | 27篇 |
2004年 | 18篇 |
2003年 | 25篇 |
2002年 | 16篇 |
2001年 | 21篇 |
2000年 | 23篇 |
1999年 | 27篇 |
1998年 | 53篇 |
1997年 | 53篇 |
1996年 | 40篇 |
1995年 | 32篇 |
1994年 | 33篇 |
1993年 | 39篇 |
1992年 | 13篇 |
1991年 | 12篇 |
1990年 | 21篇 |
1989年 | 43篇 |
1988年 | 33篇 |
1987年 | 37篇 |
1986年 | 21篇 |
1985年 | 11篇 |
1984年 | 15篇 |
1983年 | 8篇 |
1982年 | 10篇 |
1981年 | 16篇 |
1980年 | 14篇 |
1977年 | 9篇 |
1976年 | 7篇 |
1975年 | 6篇 |
1973年 | 6篇 |
1963年 | 6篇 |
1955年 | 5篇 |
1941年 | 11篇 |
排序方式: 共有1243条查询结果,搜索用时 15 毫秒
101.
102.
103.
104.
Li Ma David MacTavish Frédéric Simonin Jean-Jacques Bourguignon Takeshi Watanabe Jack H. Jhamandas 《The European journal of neuroscience》2009,30(8):1585-1593
Prolactin-releasing peptide (PrRP), an RF amide peptide present in the brain, generates a wide variety of centrally generated autonomic responses, including increases in arterial blood pressure and heart rate. The identity of the receptor mediating the effects of PrRP is unknown. In addition to GPR10, which is its putative endogenous receptor, PrRP demonstrates a high binding affinity for Neuropeptide FF (NPFF) receptors, specifically the NPFF2 receptor. In the present study, we examined whether the central cardiovascular effects of PrRP in the intact animal and its cellular effects on parvocellular paraventricular nucleus (PVN) neurons are mediated via NPFF receptors. In conscious rats, intracerebroventricular (i.c.v.) PrRP caused an increase in arterial blood pressure and heart rate, which was blocked with RF9, a specific NPFF receptor antagonist. These PrRP-evoked cardiovascular effects were preserved in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat strain, in which the GRP10 receptor gene was mutated. In rat brain slices, whole-cell patch clamp recordings of parvocellular paraventricular nucleus neurons show PrRP caused a decrease in evoked and miniature GABAergic inhibitory postsynaptic currents (IPSCs), effects that were antagonized by RF9, but not neuropeptide Y, a putative GPR10 receptor antagonist. The effects of PrRP on IPSCs in OLETF rats were similar to those in wild-type rats. Both in vivo and in vitro data strongly suggest that certain PrRP effects in the brain are expressed via NPFF receptors, probably NPFF2, rather than the GPR10 receptor. These observations may assume clinical relevance as RF amide peptides such NPFF and PrRP become therapeutic targets for a variety of autonomically related disorders. 相似文献
105.
106.
107.
108.
Normal and stenotic renal arteries: experimental balloon-expandable intraluminal stenting 总被引:2,自引:0,他引:2
Palmaz JC; Kopp DT; Hayashi H; Schatz RA; Hunter G; Tio FO; Garcia O; Alvarado R; Rees C; Thomas SC 《Radiology》1987,164(3):705-708
Elastic recoil of the vessel wall is a common cause of failure of percutaneous transluminal angioplasty in renal arteries. To oppose such recoil, balloon-expandable metal stents were implanted in artificially stenotic renal arteries in pigs and normal renal arteries in dogs and pigs. The stents were then examined angiographically and histologically at regular intervals. All stents were completely covered with endothelialized neointima in 3 weeks. There was no difference in intimal thickness between the stenotic and nonstenotic renal arteries. A large stent diameter and a large open or nonmetal surface may cause less intimal hyperplasia, but nonturbulent, fast arterial flow is probably the most important factor in ensuring long-term patency of the vessel. 相似文献
109.
110.
Rudy W; Guckel B; Siebels M; Lindauer M; Meuer SC; Moebius U 《International immunology》1997,9(6):853-860
Introduction of co-stimulatory molecules like CD80 and CD86 represents a
means to augment the immunogenicity of tumor cells and to induce immune
responses directed at tumor antigens. Here we compared CD80- and
CD86-transfected human melanoma cells to induce primary immune responses by
their capacity to promote proliferation of human allogeneic resting T
lymphocytes. CD80- and CD86-transfected SkMel63 melanoma cells induced T
cell activation to a comparable degree, which was found to be independent
of the cell surface density of these co- stimulatory molecules.
Co-expression of CD80 and CD86 did not result in a synergistic increase in
T cell proliferation. Both CD80 and CD86 transfectants induced the
proliferation of isolated CD4+ or CD8+ T cells. Exogenous IL-2, IL-4 and
tumor necrosis factor-alpha respectively enhanced primary T cell
proliferation independent of CD80 or CD86 expression. Interestingly,
differential activities of CD80 and CD86 were observed following
stimulation of resting T cells in the presence of IL-12. Whereas IL-12
increased T cell proliferation in the presence of CD86-transfected melanoma
cells, it exhibited an inhibitory function in the presence of
CD80-expressing SkMel63 cells. Experimental evidence indicates that this
inhibitory effect was mediated by IFN- gamma since (I) IFN-gamma secretion
of stimulated T cells was augmented by IL-12, (II) exogenous IFN-gamma also
inhibited T cell proliferation induced by CD80- but not CD86-transfected
SkMel63 cells and (III) the inhibitory effect of IL-12 was blocked by an
anti-IFN-gamma mAb.
相似文献