全文获取类型
收费全文 | 1692525篇 |
免费 | 126375篇 |
国内免费 | 3779篇 |
专业分类
耳鼻咽喉 | 21730篇 |
儿科学 | 55634篇 |
妇产科学 | 46151篇 |
基础医学 | 241206篇 |
口腔科学 | 48738篇 |
临床医学 | 151309篇 |
内科学 | 333494篇 |
皮肤病学 | 38651篇 |
神经病学 | 131139篇 |
特种医学 | 63868篇 |
外国民族医学 | 242篇 |
外科学 | 257222篇 |
综合类 | 38948篇 |
现状与发展 | 4篇 |
一般理论 | 532篇 |
预防医学 | 124223篇 |
眼科学 | 40215篇 |
药学 | 123593篇 |
7篇 | |
中国医学 | 4475篇 |
肿瘤学 | 101298篇 |
出版年
2021年 | 12783篇 |
2019年 | 13522篇 |
2018年 | 19952篇 |
2017年 | 15214篇 |
2016年 | 16618篇 |
2015年 | 18959篇 |
2014年 | 26215篇 |
2013年 | 37943篇 |
2012年 | 52724篇 |
2011年 | 55416篇 |
2010年 | 32770篇 |
2009年 | 30693篇 |
2008年 | 51514篇 |
2007年 | 54794篇 |
2006年 | 55252篇 |
2005年 | 52535篇 |
2004年 | 50738篇 |
2003年 | 48150篇 |
2002年 | 46369篇 |
2001年 | 91783篇 |
2000年 | 93606篇 |
1999年 | 76959篇 |
1998年 | 19717篇 |
1997年 | 17267篇 |
1996年 | 17391篇 |
1995年 | 16742篇 |
1994年 | 15289篇 |
1993年 | 14071篇 |
1992年 | 57381篇 |
1991年 | 55270篇 |
1990年 | 52970篇 |
1989年 | 50747篇 |
1988年 | 46132篇 |
1987年 | 44937篇 |
1986年 | 42226篇 |
1985年 | 39987篇 |
1984年 | 29348篇 |
1983年 | 24908篇 |
1982年 | 13898篇 |
1979年 | 25529篇 |
1978年 | 17574篇 |
1977年 | 14906篇 |
1976年 | 13874篇 |
1975年 | 14563篇 |
1974年 | 17630篇 |
1973年 | 16944篇 |
1972年 | 15673篇 |
1971年 | 14453篇 |
1970年 | 13431篇 |
1969年 | 12517篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
We report a Chinese family with members affected by epidermolytic ichthyosis (EI), caused by KRT gene mutations. The proband was a 14‐year‐old boy who had simultaneous appearance of nephroblastoma and epidermolytic ichthyosis (EI). Both the patient and his mother exhibited the specific clinical and pathological manifestations of EI. We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G>C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q). The KRT10 gene had no mutations. 相似文献
32.
33.
34.
Christopher D Hue Frances S Cho Siqi Cao Cameron R ”Dale” Bass David F Meaney Barclay Morrison III 《Journal of cerebral blood flow and metabolism》2015,35(7):1191-1198
Owing to the frequent incidence of blast-induced traumatic brain injury (bTBI) in recent military conflicts, there is an urgent need to develop effective therapies for bTBI-related pathologies. Blood-brain barrier (BBB) breakdown has been reported to occur after primary blast exposure, making restoration of BBB function and integrity a promising therapeutic target. We tested the hypothesis that treatment with dexamethasone (DEX) after primary blast injury potentiates recovery of an in vitro BBB model consisting of mouse brain endothelial cells (bEnd.3). DEX treatment resulted in complete recovery of transendothelial electrical resistance and hydraulic conductivity 1 day after injury, compared with 3 days for vehicle-treated injured cultures. Administration of RU486 (mifepristone) inhibited effects of DEX, confirming that barrier restoration was mediated by glucocorticoid receptor signaling. Potentiated recovery with DEX treatment was accompanied by stronger zonula occludens (ZO)-1 tight junction immunostaining and expression, suggesting that increased ZO-1 expression was a structural correlate to BBB recovery after blast. Interestingly, augmented ZO-1 protein expression was associated with specific upregulation of the α+ isoform but not the α− isoform. This is the first study to provide a mechanistic basis for potentiated functional recovery of an in vitro BBB model because of glucocorticoid treatment after primary blast injury. 相似文献
35.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
36.
M.T. Leccia N. Auffret F. Poli J.‐P. Claudel S. Corvec B. Dreno 《Journal of the European Academy of Dermatology and Venereology》2015,29(8):1485-1492
Acne vulgaris (acne) is a chronic inflammatory disease of the sebaceous gland, characterized by follicular hyperkeratinization, excessive colonization by Propionibacterium acnes (P. acnes) as well as immune reactions and inflammation. Despite an armamentarium of topical treatments available including benzoyl peroxide, retinoids and azelaic acid, topical antibiotics in monotherapies, especially erythromycin and clindamycin, are still used in Europe to treat acne. This intensive use led to antimicrobial‐resistant P. acnes and staphylococci strains becoming one of the main health issues worldwide. This is an update on the current topical acne treatments available in Europe, their mechanism of action, their potential to induce antimicrobial resistance and their clinical efficacy and safety. 相似文献
37.
38.
Pradeep Balasubramanian M.D. C. R. Srinivas M.D. Pavai Arunachalam M.S. M.Ch. K. S. Thirumurthy M.S. M.Ch. P. R. Rajkumar M.S. M.Ch. H. Manuvidhya M.B.B.S. 《Pediatric dermatology》2015,32(3):e78-e81
We report on a child with several café au lait spots in association with a lumbar lipomeningomyelocele as an apparently new association. Cutaneous markers, the identification of which plays a crucial role in the early diagnosis and management of spinal malformations, can accompany occult spinal dysraphism. Herein we report a case of lumbar lipomeningomyelocele associated with an overlying café au lait spot that served as a marker of occult spinal dysraphism. The patient also had segmental café au lait spots on the face, making the association unique. 相似文献
39.
Loss‐of‐function mutations in the gene encoding filaggrin underlie a Japanese family with food‐dependent exercise‐induced anaphylaxis
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
40.
P. A. Hannan J. A. Khan A. Khan S. Safiullah 《Indian journal of pharmaceutical sciences》2016,78(1):2-7
Dosage form is a mean used for the delivery of drug to a living body. In order to get the desired effect the drug should be delivered to its site of action at such rate and concentration to achieve the maximum therapeutic effect and minimum adverse effect. Since oral route is still widely accepted route but having a common drawback of difficulty in swallowing of tablets and capsules. Therefore a lot of research has been done on novel drug delivery systems. This review is about oral dispersible tablets a novel approach in drug delivery systems that are now a day''s more focused in formulation world, and laid a new path that, helped the patients to build their compliance level with the therapy, also reduced the cost and ease the administration especially in case of pediatrics and geriatrics. Quick absorption, rapid onset of action and reduction in drug loss properties are the basic advantages of this dosage form. 相似文献