全文获取类型
收费全文 | 422篇 |
免费 | 41篇 |
专业分类
儿科学 | 20篇 |
妇产科学 | 27篇 |
基础医学 | 66篇 |
口腔科学 | 4篇 |
临床医学 | 40篇 |
内科学 | 108篇 |
皮肤病学 | 9篇 |
神经病学 | 25篇 |
特种医学 | 4篇 |
外科学 | 55篇 |
预防医学 | 48篇 |
眼科学 | 1篇 |
药学 | 16篇 |
肿瘤学 | 40篇 |
出版年
2023年 | 3篇 |
2022年 | 7篇 |
2021年 | 28篇 |
2020年 | 16篇 |
2019年 | 20篇 |
2018年 | 21篇 |
2017年 | 12篇 |
2016年 | 11篇 |
2015年 | 16篇 |
2014年 | 23篇 |
2013年 | 27篇 |
2012年 | 48篇 |
2011年 | 39篇 |
2010年 | 21篇 |
2009年 | 24篇 |
2008年 | 24篇 |
2007年 | 24篇 |
2006年 | 13篇 |
2005年 | 23篇 |
2004年 | 16篇 |
2003年 | 13篇 |
2002年 | 11篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有463条查询结果,搜索用时 16 毫秒
61.
Collin J. Popp Margaret Curran Chan Wang Malini Prasad Keenan Fine Allen Gee Nandini Nair Katherine Perdomo Shirley Chen Lu Hu David E. St-Jules Emily N. C. Manoogian Satchidananda Panda Mary Ann Sevick Blandine Laferrre 《Nutrients》2021,13(12)
We aim to describe temporal eating patterns in a population of adults with overweight or obesity. In this cross-sectional analysis, data were combined from two separate pilot studies during which participants entered the timing of all eating occasions (>0 kcals) for 10–14 days. Data were aggregated to determine total eating occasions, local time of the first and last eating occasions, eating window, eating midpoint, and within-person variability of eating patterns. Eating patterns were compared between sexes, as well as between weekday and weekends. Participants (n = 85) had a median age of 56 ± 19 years, were mostly female (>70%), white (56.5%), and had a BMI of 31.8 ± 8.0 kg/m2. The median eating window was 14 h 04 min [12 h 57 min–15 h 21 min], which was significantly shorter on the weekend compared to weekdays (p < 0.0001). Only 13.1% of participants had an eating window <12 h/d. Additionally, there was greater irregularity with the first eating occasion during the week when compared to the weekend (p = 0.0002). In conclusion, adults with overweight or obesity have prolonged eating windows (>14 h/d). Future trials should examine the contribution of a prolonged eating window on adiposity independent of energy intake. 相似文献
62.
Viateur Tuyisenge Lena Trebaul Manik Bhattacharjee Blandine Chanteloup-Forêt Carole Saubat-Guigui Ioana Mîndruţă Sylvain Rheims Louis Maillard Philippe Kahane Delphine Taussig Olivier David 《Clinical neurophysiology》2018,129(3):548-554
Objective
Intracranial electroencephalographic (iEEG) recordings contain “bad channels”, which show non-neuronal signals. Here, we developed a new method that automatically detects iEEG bad channels using machine learning of seven signal features.Methods
The features quantified signals’ variance, spatial–temporal correlation and nonlinear properties. Because the number of bad channels is usually much lower than the number of good channels, we implemented an ensemble bagging classifier known to be optimal in terms of stability and predictive accuracy for datasets with imbalanced class distributions. This method was applied on stereo-electroencephalographic (SEEG) signals recording during low frequency stimulations performed in 206 patients from 5 clinical centers.Results
We found that the classification accuracy was extremely good: It increased with the number of subjects used to train the classifier and reached a plateau at 99.77% for 110 subjects. The classification performance was thus not impacted by the multicentric nature of data.Conclusions
The proposed method to automatically detect bad channels demonstrated convincing results and can be envisaged to be used on larger datasets for automatic quality control of iEEG data.Significance
This is the first method proposed to classify bad channels in iEEG and should allow to improve the data selection when reviewing iEEG signals. 相似文献63.
64.
65.
Wen Lun Yuan Sophie Nicklaus Anne Forhan Claire Chabanet Barbara Heude Marie-Aline Charles Christine Lange Blandine de Lauzon-Guillain 《Nutrients》2021,13(8)
An exposure to sweetened and fatty foods early in life may be involved in high liking later in life. The objective is to investigate the association between dietary exposure to carbohydrate, sugars and fat in infancy, with liking for sweetness, fattiness and fattiness-and-sweetness sensations at 8-to-12-year-old. Analyses were conducted on 759 French children from the EDEN mother-child cohort. Carbohydrate, sugar or fat intake, being a consumer of added sugars or added fats were assessed at 8 and 12 months using 3-day food records. The liking score (0–10) for the different sensations was assessed through an online child-completed questionnaire. Associations were tested by linear regressions adjusted for main confounders and the interaction with sex was tested. None of the early dietary exposure variables was related to fattiness liking. Carbohydrate intake at 8 months was positively but weakly associated with liking for sweetness-and-fattiness. In girls only, carbohydrate intake at 12 months was positively associated with liking for sweetness. Globally, no marked associations were observed between infant dietary exposure to sweet and fat and liking for sweetness and fattiness in young children. The positive link in girls between early carbohydrate exposure and later liking for sweetness needs to be confirmed in further studies. 相似文献
66.
67.
Pez F Dayan F Durivault J Kaniewski B Aimond G Le Provost GS Deux B Clézardin P Sommer P Pouysségur J Reynaud C 《Cancer research》2011,71(5):1647-1657
68.
Laferrère B Reilly D Arias S Swerdlow N Gorroochurn P Bawa B Bose M Teixeira J Stevens RD Wenner BR Bain JR Muehlbauer MJ Haqq A Lien L Shah SH Svetkey LP Newgard CB 《Science translational medicine》2011,3(80):80re2
Glycemic control is improved more after gastric bypass surgery (GBP) than after equivalent diet-induced weight loss in patients with morbid obesity and type 2 diabetes mellitus. We applied metabolomic profiling to understand the mechanisms of this better metabolic response after GBP. Circulating amino acids (AAs) and acylcarnitines (ACs) were measured in plasma from fasted subjects by targeted tandem mass spectrometry before and after a matched 10-kilogram weight loss induced by GBP or diet. Total AAs and branched-chain AAs (BCAAs) decreased after GBP, but not after dietary intervention. Metabolites derived from BCAA oxidation also decreased only after GBP. Principal components (PC) analysis identified two major PCs, one composed almost exclusively of ACs (PC1) and another with BCAAs and their metabolites as major contributors (PC2). PC1 and PC2 were inversely correlated with pro-insulin concentrations, the C-peptide response to oral glucose, and the insulin sensitivity index after weight loss, whereas PC2 was uniquely correlated with levels of insulin resistance (HOMA-IR). These data suggest that the enhanced decrease in circulating AAs after GBP occurs by mechanisms other than weight loss and may contribute to the better improvement in glucose homeostasis observed with the surgical intervention. 相似文献
69.
70.
Keo HH Baumgartner I Hirsch AT Duval S Steg PG Pasquet B Bhatt DL Roether J;REACH Registry Investigators 《Vascular medicine (London, England)》2011,16(5):323-330
We aimed to evaluate whether carotid intima-media thickness (CIMT) or the presence of plaque can confer additional predictive value of future cardiovascular (CV) ischemic events in patients with pre-existing atherosclerotic vascular disease. We identified 2317 patients enrolled in the REduction of Atherothrombosis for Continued Health (REACH) registry who had atherosclerotic vascular disease and baseline CIMT measurements. The entire range of CIMT was divided into quartiles and the fourth quartile (≥ 1.5 mm) was defined as carotid plaque. Mean ± standard deviation baseline CIMT was 1.31 ± 0.65 mm. Associated CV ischemic events and vascular-related hospitalizations were evaluated over a 2-year follow-up. There was a positive increase in adjusted hazard ratios (HRs) for all-cause mortality (p = 0.04 for trend) and the quadruple endpoint (CV death, myocardial infarction (MI), stroke, hospitalization for CV events) with increasing quartiles of CIMT (p = 0.0008 for trend), which was mainly driven by the fourth quartile (carotid plaque). HRs for all-cause mortality, CV death, CV death/MI/stroke and the quadruple endpoint comparing the highest (carotid plaque) with the lowest CIMT quartile were 2.09 (95% CI, 1.07-4.10; p = 0.03); 2.49 (1.10-5.67; p = 0.03); 1.71 (1.10-2.67; p = 0.02); and 1.73 (1.31-2.27; p = 0.0001). In conclusion, our analyses suggest that the presence of carotid plaque, rather than the thickness of intima-media, appears to be associated with increased risk of CV morbidity and mortality, but confirmation of these findings in other population and prospective studies is required. 相似文献