全文获取类型
收费全文 | 2458446篇 |
免费 | 180692篇 |
国内免费 | 3425篇 |
专业分类
耳鼻咽喉 | 33885篇 |
儿科学 | 79778篇 |
妇产科学 | 65317篇 |
基础医学 | 364842篇 |
口腔科学 | 67319篇 |
临床医学 | 220988篇 |
内科学 | 477267篇 |
皮肤病学 | 54917篇 |
神经病学 | 196903篇 |
特种医学 | 92731篇 |
外国民族医学 | 489篇 |
外科学 | 370296篇 |
综合类 | 48011篇 |
现状与发展 | 12篇 |
一般理论 | 885篇 |
预防医学 | 189301篇 |
眼科学 | 56867篇 |
药学 | 183007篇 |
11篇 | |
中国医学 | 4743篇 |
肿瘤学 | 134994篇 |
出版年
2021年 | 20037篇 |
2019年 | 20722篇 |
2018年 | 29542篇 |
2017年 | 22481篇 |
2016年 | 25498篇 |
2015年 | 27960篇 |
2014年 | 38646篇 |
2013年 | 58571篇 |
2012年 | 80649篇 |
2011年 | 86049篇 |
2010年 | 50834篇 |
2009年 | 47102篇 |
2008年 | 81321篇 |
2007年 | 86549篇 |
2006年 | 87081篇 |
2005年 | 84490篇 |
2004年 | 80728篇 |
2003年 | 78046篇 |
2002年 | 75573篇 |
2001年 | 112053篇 |
2000年 | 115530篇 |
1999年 | 95932篇 |
1998年 | 28076篇 |
1997年 | 24553篇 |
1996年 | 24752篇 |
1995年 | 23294篇 |
1994年 | 21479篇 |
1993年 | 20273篇 |
1992年 | 72584篇 |
1991年 | 70581篇 |
1990年 | 68886篇 |
1989年 | 66146篇 |
1988年 | 60766篇 |
1987年 | 59623篇 |
1986年 | 55662篇 |
1985年 | 53621篇 |
1984年 | 39899篇 |
1983年 | 33889篇 |
1982年 | 20396篇 |
1979年 | 36302篇 |
1978年 | 26030篇 |
1977年 | 21639篇 |
1976年 | 20692篇 |
1975年 | 22179篇 |
1974年 | 26497篇 |
1973年 | 25119篇 |
1972年 | 23448篇 |
1971年 | 22310篇 |
1970年 | 20518篇 |
1969年 | 19531篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Timothy J. Cordingley Mark A.G. Wilson Kathryn M. Weston 《Health & social care in the community》2022,30(1):353-359
Vaccination is a vital health care initiative to prevent individual and population infection. To increase vaccination rates the federal government implemented the ‘No Jab, No Pay’ policy, where eligibility for several government benefits required children to be fully vaccinated by removing ‘conscientious objections’ and expanding the age range of children whose families receive benefits. This study assesses the impact of this policy at a local area within a single medical practice community in NSW, Australia. A retrospective clinical audit was performed between 2012 and 2017 on a single general practice's vaccination records for children ≤19 years. Catch-up vaccinations were assessed based on age at vaccination. Incidence of catch-up vaccinations was assessed for each of four years before and two years after the implementation of the ‘No Jab, No Pay’ policy in January 2016, along with the age of children and vaccination(s) given. Catch-up vaccinations were assessed temporally either side of implementation of ‘No Jab, No Pay’. Comparing the average annual vaccination catch-up incidence rate of 6.2% pre-implementation (2012–2015), there was an increase to 9.2% in 2016 (p < .001) and 7.8% in 2017 (p = .027). Secondary outcome measurement of catch-up vaccination incidence rates before (2012–2015) and after (2016–2017) ‘No Jab, No Pay’ implementation showed statistically significant increases for children aged 8–11 years (3.2%–5.6%, p = .038), 12–15 years (7.5%–14.7%, p < .001) and 16–19 years (3.3%–10.2%, p < .001) along with a statistically significant reduction in children aged 1–3 years (11.4%–6.2%, p = .015). Also, catch-up rates for DTPa significantly increased after program implementation. This study demonstrates that the Australian federal government vaccination policy ‘No Jab, No Pay’ was coincident with an increase in catch-up vaccinations within a rural NSW community served by one medical practice, especially for older children. 相似文献
22.
23.
Marike Gabrielson Mattias Hammarström Magnus Bäcklund Jenny Bergqvist Kristina Lång Ann H Rosendahl Signe Borgquist Roxanna Hellgren Kamila Czene Per Hall 《International journal of cancer. Journal international du cancer》2023,152(11):2362-2372
Tamoxifen prevents recurrence of breast cancer and is suggested for preventive risk-reducing therapy. Tamoxifen reduces mammographic density, a proxy for therapy response, but little is known about its effects in remodelling normal breast tissue. Our study, a substudy within the double-blinded dose-determination trial KARISMA, investigated tamoxifen-specific changes in breast tissue composition and histological markers in healthy women. We included 83 healthy women randomised to 6 months daily intake of 20, 10, 5, 2.5, 1 mg of tamoxifen or placebo. The groups were combined to “no dose” (0-1 mg), “low-dose” (2.5-5 mg) or “high-dose” (10-20 mg) of tamoxifen. Ultrasound-guided biopsies were collected before and after tamoxifen exposure. In each biopsy, epithelial, stromal and adipose tissues was quantified, and expression of epithelial and stromal Ki67, oestrogen receptor (ER) and progesterone receptor (PR) analysed. Mammographic density using STRATUS was measured at baseline and end-of-tamoxifen-exposure. We found that different doses of tamoxifen reduced mammographic density and glandular-epithelial area in premenopausal women and associated with reduced epithelium and increased adipose tissue. High-dose tamoxifen also decreased epithelial ER and PR expressions in premenopausal women. Premenopausal women with the greatest reduction in proliferation also had the greatest epithelial reduction. In postmenopausal women, high-dose tamoxifen decreased the epithelial area with no measurable density decrease. Tamoxifen at both low and high doses influences breast tissue composition and expression of histological markers in the normal breast. Our findings connect epithelial proliferation with tissue remodelling in premenopausal women and provide novel insights to understanding biological mechanisms of primary prevention with tamoxifen. 相似文献
24.
25.
26.
Troppmair Teresa Egger J. Krösbacher A. Zanvettor A. Schinnerl A. Neumayr A. Baubin M. 《Der Anaesthesist》2022,71(4):272-280
Die Anaesthesiologie - Die Qualität eines Rettungssystems zeichnet sich auch durch den effizienten Einsatz seiner personellen und Fahrzeugressourcen aus. So können im berechtigten Fall... 相似文献
27.
28.
29.
30.
Xiying Fan Glen A. Bjerke Kent Riemondy Li Wang Rui Yi 《Molecular carcinogenesis》2019,58(12):2241-2253
MicroRNAs (miRNAs) play important roles in prostate cancer development. However, it remains unclear how individual miRNAs contribute to the initiation and progression of prostate cancer. Here we show that a basal layer‐enriched miRNA is required for prostate tumorigenesis. We identify miR‐205 as the most highly expressed miRNA and enriched in the basal cells of the prostate. Although miR‐205 is not required for normal prostate development and homeostasis, genetic deletion of miR‐205 in a Pten null tumor model significantly compromises tumor progression and does not promote metastasis. In Pten null basal cells, loss of miR‐205 attenuates pAkt levels and promotes cellular senescence. Furthermore, although overexpression of miR‐205 in prostate cancer cells with luminal phenotypes inhibits cell growth in both human and mouse, miR‐205 has a minimal effect on the growth of a normal human prostate cell line. Taken together, we have provided genetic evidence for a requirement of miR‐205 in the progression of Pten null‐induced prostate cancer. 相似文献