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排序方式: 共有514条查询结果,搜索用时 15 毫秒
81.
D. Clerc J.F. Delfraissy D. Sallire M. Bisson P. Massias 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》1984,5(4):315-320
Two cases of classical rheumatoid arthritis complicated by the development of a glomerulopaty independently of drug treatment are presented. Renal biopsy showed membranous glomerulonephritis in one case and fusion of foot processes in the second. The literature is reviewed and the possible relationships between rheumatoid arthritis and these glomerulopathies are discussed. The authors conclude to the absence of causal relationship between these two diseases. 相似文献
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83.
Bisson GP Frank I Gross R Lo Re V Strom JB Wang X Mogorosi M Gaolathe T Ndwapi N Friedman H Strom BL Dickinson D 《AIDS (London, England)》2006,20(9):1333-1336
A large number of HIV-infected patients in sub-Saharan Africa pay out-of-pocket for HAART. This analysis from Botswana indicates that higher median out-of-pocket regimen costs to patients for the initial 30 days of HAART are associated with failure to achieve a viral load< 400 copies/ml [US$32; interquartile range (IQR), 20-84 compared with US$22; (IQR, 17-36), P = 0.001]. HAART costs should be minimized as scale-up efforts in sub-Saharan Africa progress. 相似文献
84.
Luke K. Butler Isabelle-Anne Bisson Timothy J. Hayden Martin Wikelski L. Michael Romero 《General and comparative endocrinology》2009,162(3):313-318
Dependent young are often easy targets for predators, so for many parent vertebrates, responding to offspring-directed threats is a fundamental part of reproduction. We tested the parental adrenocortical response of the endangered black-capped vireo (Vireo atricapilla) and the common white-eyed vireo (V. griseus) to acute and chronic threats to their offspring. Like many open-nesting birds, our study species experience high offspring mortality. Parents responded behaviorally to a predator decoy or human 1–2 m from their nests, but, in contrast to similar studies of cavity-nesting birds, neither these acute threats nor chronic offspring-directed threats altered plasma corticosterone concentrations of parents. Although parents in this study showed no corticosterone response to offspring-directed threats, they always increased corticosterone concentrations in response to capture. To explain these results, we propose that parents perceive their risk of nest-associated death differently depending on nest type, with cavity-nesting adults perceiving greater risk to themselves than open-nesters that can readily detect and escape from offspring-directed threats. Our results agree with previous studies suggesting that the hypothalamic–pituitary–adrenal axis, a major physiological mechanism for coping with threats to survival, probably plays no role in coping with threats to offspring when risks to parents and offspring are not correlated. We extend that paradigm by demonstrating that nest style may influence how adults perceive the correlation between offspring-directed and self-directed threats. 相似文献
85.
A Hirsch F Windhausen JG Tijssen AJ Oude Ophuis WJ van der Giessen PM van der Zee JH Cornel FW Verheugt RJ de Winter 《European heart journal》2009,30(6):645-654
AIMS: In several observational studies, revascularization is associated with substantial reduction in mortality in patients with non-ST-segment elevation acute coronary syndrome (nSTE-ACS). This has strengthened the belief that routine early angiography would lead to a reduction in mortality. We investigated the association between actual in-hospital revascularization and long-term outcome in patients with nSTE-ACS included in the ICTUS trial. METHODS AND RESULTS: The study population of the present analysis consists of ICTUS participants who were discharged alive after initial hospitalization. The ICTUS trial was a randomized, controlled trial in which 1200 patients were randomized to an early invasive or selective invasive strategy. The endpoints were death from hospital discharge until 4 year follow-up and death or spontaneous myocardial infarction (MI) until 3 years. Among 1189 patients discharged alive, 691 (58%) underwent revascularization during initial hospitalization. In multivariable Cox regression analyses, in-hospital revascularization was independently associated with a reduction in 4 year mortality and 3 year event rate of death or spontaneous MI: hazard ratio (HR) 0.59 [95% confidence interval (CI) 0.37-0.96] and 0.46 (95% CI 0.31-0.68). However, when intention-to-treat analysis was performed, no differences in cumulative event rates were observed between the early invasive and selective invasive strategies: HR 1.10 (95% CI 0.70-1.74) for death and 1.27 (95% CI 0.88-1.85) for death or spontaneous MI. CONCLUSION: The ICTUS trial did not show that an early invasive strategy resulted in a better outcome than a selective invasive strategy in patients with nSTE-ACS. However, similar to retrospective analyses from observational studies, actual revascularization was associated with lower mortality and fewer MI. Whether an early invasive strategy leads to a better outcome than a selective invasive strategy cannot be inferred from the observation that revascularized patients have a better prognosis in non-randomized studies. 相似文献
86.
87.
Masanori Ishiguro Corey B. Puryear Erica Bisson Ryan Jewell David J. Nathan Bruce I. Tranmer George C. Wellman 《第三军医大学学报》2004,26(4):301-303
Introduction Subarachnoidhemorrhage (SAH) ,causedbytheruptureofcerebralaneurysms,isassociatedwithsubstantialmorbid ityandmortality ,withadelayedandsustainedvasoconstric tion (vasospasm)implicatedasthemajorcauseofdeathanddisabilityinpatientssurvivingthein… 相似文献
88.
Messaoudi M Lalonde R Violle N Javelot H Desor D Nejdi A Bisson JF Rougeot C Pichelin M Cazaubiel M Cazaubiel JM 《The British journal of nutrition》2011,105(5):755-764
In a previous clinical study, a probiotic formulation (PF) consisting of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (PF) decreased stress-induced gastrointestinal discomfort. Emerging evidence of a role for gut microbiota on central nervous system functions therefore suggests that oral intake of probiotics may have beneficial consequences on mood and psychological distress. The aim of the present study was to investigate the anxiolytic-like activity of PF in rats, and its possible effects on anxiety, depression, stress and coping strategies in healthy human volunteers. In the preclinical study, rats were daily administered PF for 2 weeks and subsequently tested in the conditioned defensive burying test, a screening model for anti-anxiety agents. In the clinical trial, volunteers participated in a double-blind, placebo-controlled, randomised parallel group study with PF administered for 30?d and assessed with the Hopkins Symptom Checklist (HSCL-90), the Hospital Anxiety and Depression Scale (HADS), the Perceived Stress Scale, the Coping Checklist (CCL) and 24?h urinary free cortisol (UFC). Daily subchronic administration of PF significantly reduced anxiety-like behaviour in rats (P?0·05) and alleviated psychological distress in volunteers, as measured particularly by the HSCL-90 scale (global severity index, P?0·05; somatisation, P?0·05; depression, P?0·05; and anger-hostility, P?0·05), the HADS (HADS global score, P?0·05; and HADS-anxiety, P?0·06), and by the CCL (problem solving, P?0·05) and the UFC level (P?0·05). L. helveticus R0052 and B. longum R0175 taken in combination display anxiolytic-like activity in rats and beneficial psychological effects in healthy human volunteers. 相似文献
89.
90.