Effects of hexamethonium, biperiden and phentolamine on the vasoconstrictive effects of oculomotor nerve stimulation in rabbits.

The surface ultrastructure of epithelial cells of the mature lens and their contiguous layers, the capsule and developing cortical fibers were studied by scanning electron microscopy. The cells of the concentric zones of the epithelium (central, intermediate and equatorial) display significant differences in size, shape and fine surface morphology. The three-dimensional aspects of their association with the capsule and the underlying cortical fibers are shown and discussed. The basal lamina of the capsule appears to be attached to the underlying epithelial cells along the cell borders and, in the central-intermediate zones, at various points on the cell surfaces. The developing cortical fibers show button-shaped structures and depressions on their surfaces and complex patterns of elongate cellular projections.     

Thyroid Function in Normals: Influences on the Electroencephalogram and Cognitive Performance

Recently it has been suggested that thyroid function may influence neuropsychological processes not only as a result of thyroid disease but also through normal neurophysiologic adaptive mechanisms. In 69 normal university students, levels of thyroid stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) were assayed in blood samples and related to measures of cognitive performance and to spectral measures of the EEG recorded during cognitive performance. Significant relationships were found between T3 levels and delta power in the EEG from occipital leads, with higher T3 associated with less EEG power in the left hemisphere and greater power in the right hemisphere. Higher T3 levels were associated with poorer performance on several cognitive tasks, particularly for males, although the males with higher T3 levels also showed faster correct responses on a word fluency task. These results seem to support the hypothesis that an individual's characteristic level of thyroid function is relevant to normal neuropsychological processes.     

Inhibition of reoviruses in vitro by selected antiviral substances

The antiviral effect of 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin), 3-deazaguanine (3-DG), 3-deazauridine (3-DU) and 9-(S)-(2,3-dihydroxypropyl)adenine ([S]-DHPA) on reovirus types 1, 2 and 3 replication and host cell functions are described. Inhibition of cytopathic effect (CPE) and of immunofluorescent cell counts (IFCC) were determined to assess antiviral activity in Madin-Darby bovine kidney (MDBK) cells. Ribavirin showed the strongest inhibitory effects with inhibition at 3.2 μg/ml. 3-DG and 3-DU had moderate activity and (S)-DHPA exhibited only weak effects. There was little difference in the degree of inhibition among reovirus serotypes. Antiviral effects were reversed by guanosine (for ribavirin and 3-DG), uridine (for 3-DU) and adenosine (for [S]-DHPA). Comparative studies with reovirus type 3 indicated both CPE and IFCC inhibition to be approximately equally sensitive parameters. In radiolabel uptake studies, each compound moderately inhibited uptake of radioactive precursor molecules at dosage levels where viral inhibition was observed, suggesting a lack of specific reovirus inhibitory effects.     

Radiofrequency Wire Recanalization of Chronically Thrombosed TIPS

Radiofrequency (RF) guide wires have been applied to cardiac interventions, recanalization of central venous thromboses, and to cross biliary occlusions. Herein, the use of a RF wire technique to revise chronically occluded transjugular intrahepatic portosystemic shunts (TIPS) is described. In both cases, conventional TIPS revision techniques failed to revise the chronically thrombosed TIPS. RF wire recanalization was successfully performed through each of the chronically thrombosed TIPS, demonstrating initial safety and feasibility in this application.     

Management of the Maxilla After Alveolar Ridge Augmentation With Hydroxylapatite When Opposed by Mandibular Implants

Maxillary ridge augmentation and vestibuloplasty are often adjuncts to mandibular implant reconstructions. Careful management of the augmented ridge after surgery is critical to the success of the maxillary prosthesis and osseointegration of the mandibular implant. A technique is described for alteration of an existing maxillary complete denture after ridge augmentation. Precautions regarding prosthesis function during the osseointegration phase of different types of mandibular reconstructions are noted. Technique and rationale for denture flange modification when a prosthesis is rebased for a patient who received simultaneous vestibuloplasty and ridge augmentation are described.