全文获取类型
收费全文 | 479篇 |
免费 | 25篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 30篇 |
妇产科学 | 4篇 |
基础医学 | 46篇 |
口腔科学 | 28篇 |
临床医学 | 48篇 |
内科学 | 110篇 |
皮肤病学 | 6篇 |
神经病学 | 5篇 |
特种医学 | 109篇 |
外科学 | 19篇 |
综合类 | 9篇 |
预防医学 | 35篇 |
眼科学 | 2篇 |
药学 | 25篇 |
中国医学 | 2篇 |
肿瘤学 | 44篇 |
出版年
2022年 | 2篇 |
2019年 | 12篇 |
2018年 | 8篇 |
2017年 | 6篇 |
2016年 | 10篇 |
2015年 | 11篇 |
2014年 | 8篇 |
2013年 | 24篇 |
2012年 | 8篇 |
2011年 | 7篇 |
2010年 | 26篇 |
2009年 | 27篇 |
2008年 | 9篇 |
2007年 | 15篇 |
2006年 | 9篇 |
2005年 | 11篇 |
2004年 | 16篇 |
2003年 | 5篇 |
2002年 | 7篇 |
2001年 | 3篇 |
2000年 | 7篇 |
1999年 | 7篇 |
1998年 | 30篇 |
1997年 | 32篇 |
1996年 | 26篇 |
1995年 | 24篇 |
1994年 | 24篇 |
1993年 | 18篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 6篇 |
1989年 | 15篇 |
1988年 | 16篇 |
1987年 | 9篇 |
1986年 | 15篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1983年 | 7篇 |
1982年 | 12篇 |
1981年 | 7篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 6篇 |
1941年 | 1篇 |
排序方式: 共有523条查询结果,搜索用时 15 毫秒
521.
G Merino R Real MF Baro L Gonzalez-Lobato JG Prieto AI Alvarez MM Marques 《Drug metabolism and disposition》2009,37(1):5-9
ATP-binding cassette transporter ABCG2 [breast cancer resistance protein (BCRP)] is a member of the ABC transporter superfamily that actively extrudes xenotoxins from cells and is a major determinant of the bioavailability of many compounds. ABCG2 expression is strongly induced during lactation in the mammary gland and is related to the active secretion of drugs into the milk. The presence of drug residues and environmental pollutants in milk is an outstanding problem for human milk consumption and milk industrial processes, involving important risks to public health and the dairy industry. In cows, a single nucleotide polymorphism (SNP) in this protein has been described previously (Tyr581) and is associated with higher fat and protein percentages and lower milk yield. However, whether this amino acid substitution affects ABCG2-mediated drug transport in cows, including milk secretion, required further exploration. We cloned the two variants of bovine ABCG2 and evaluated the effect of this SNP on mitoxantrone accumulation assays performed in ovine primary fibroblasts transiently expressing either of the variants. It is interesting to note that statistically significant differences in activity between both variants were observed, and the Ser581 variant was related with an increased efflux activity. In addition, we demonstrated that genistein is a very good inhibitor of bovine ABCG2 and identified new inhibitors of the transporter, such as the macrocyclic lactones, ivermectin, and selamectin. Moreover, the inhibitory effect of these compounds on human and murine ABCG2 homologs was confirmed using transduced Marbin-Dabin canine kidney II cells. These findings may have important implications regarding the presence of drug residues in milk and drug interactions affecting the pharmacological behavior of ABCG2 substrates. 相似文献
522.
Elegance TP Lam Cindy LK Lam CL Lai MF Yuen Daniel YT Fong Thomas MK So 《Health and quality of life outcomes》2009,7(1):52
Background
Few studies have evaluated the health-related quality of life (HRQOL) of Southern Chinese with chronic hepatitis B (CHB) infection. 相似文献523.