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In six young and two senile MS cases perivascular astrocytes within demyelination lesions were evaluated immunocytochemically. The peroxidase-antiperoxidase method of Sternberger et al. (1970) was used for visualization of glial fibrillary acidic protein (GFAP). In all cases very weak immunoreactivity of perivascular astrocytes was noted. Accumulation of perivascular glial fibers, and infrequently their fragmentation were observed both within active and old demyelination plaques. Clasmatodendrosis, Rosenthal's fibers and prominent regressive changes of astrocyte perikarya were found only in old plaques. A lack of immunoreactivity of perivascular astrocytes was noted within old demyelination lesions. The background of the latter was often immunonegative to GFAP. It is suggested that secondary damage of perivascular astrocytes influences vascular permeability within demyelination lesions including old plaques. 相似文献
14.
A. Dmoszyńska-Giannopoulou L. Janicka B. Sokołowska A. Ksi⇂żek G. Orłowska K. Janicki 《International urology and nephrology》1990,22(6):561-566
In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet
therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous
aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet
factor 3 and provokes a significant prolongation of the bleeding time. 相似文献
15.
Lymphocytes within the infarct area in human brain 总被引:1,自引:0,他引:1
16.
Anna Szymańska Elżbieta Korobowicz Wiesław Gołąbek 《European archives of oto-rhino-laryngology》2006,263(7):657-660
Nasopharyngeal angiofibromas occur predominantly in males in their puberty and adolescence; the incidence in other age groups and in women is exceptional. This report describes a case of a 57-year-old woman with nasopharyngeal angiofibroma presenting typical radiological findings in computed tomography, MR imaging and angiography. The tumour was successfully removed and histopathological examination confirmed the diagnosis. In 6 years follow-up the patient is free of symptoms. 相似文献
17.
Tomasz Trojanowski Jerzy P ceszyński Krzysztof Turowski Stanisław Kamiński Igor Gościński Marian Reinfus Tadeusz Krzyszkowski Marek Pyrich Adam Bielawski Czesława Leszczyk Barbara Bendarzewska Andrzej Staszczak Halina Koźniewska 《Journal of neuro-oncology》1988,6(3):285-291
A prospective, randomized trial evaluates the effects of two postoperative treatment regimens on survival in 198 adult patients with supratentorial gliomas. All patients were irradiated with 6 000 rads after possibly radical removal of tumors. CCNU administration in the dosis of 100 mg/sq m of body surface every 6–8 weeks following surgery proved to have no significant effect on the survival of patients. The median survival time in patients receiving radiation therapy alone was 61±7 weeks, while in those receiving additional chemotherapy was 56±4 weeks. Tumor histological malignancy and patients age were found to be the only important prognostic factors, irrespective of the treatment modality.
Address for offprints: T Trojanowski, Department of Neurosurgery, Medical School, Jaczewskiego 8, 20-950 Lublin, Poland 相似文献
18.
Raman and infrared spectra were made of mercuryII, cadmium and aluminum benzoates To better understand the mechanism of toxic action of heavy metals, comparisons were made of the effects of mercuryI, mercuryII, leadII, cadmium barium, strontium, copperII, aluminum, ironIII zinc, magnesium, calcium, yttrium, lanthanumIII neodymiumIII, dysprosiumIII, luthetiumIII, lithium sodium, and potassium on the aromatic system of benzoic acid. Benzoic acid was considered to be model compound, representing a wide group of aromatic ligands present in enzymes. Oscillation (Raman, IR) and electronic (UV) spectroscopy methods were applied.Heavy toxic metals, particularly HgI, HgII, and PbII in contrast to Ca, Mg, Al, FeIII, Zn, Y, and LnIII perturb the aromatic system of benzoic acid by deforming the uniforming distribution of electron charges in the ring. 相似文献
19.
20.
Mazur G Bogunia-Kubik K Wróbel T Karabon L Polak M Kuliczkowski K Lange A 《Immunology letters》2005,96(2):241-246
Multiple myeloma (MM) is a plasma cell malignancy characterised by bone marrow infiltration and the presence of a monoclonal protein in serum and/or urine. Interleukin-6 (IL-6) has been identified as one of the most important cytokines that contributes to myeloma cell survival and proliferation. Recent investigations suggest involvement of another cytokine, IL-10, in the activation of MM cells. The present study aimed to determine whether there is an association between the polymorphic features located within the promoter regions of IL-6 and IL-10 genes and progression the disease. IL-6 (-174 G/C) and IL-10 (-1082 A/G, -819 C/T, -592 A/C) promoter single nucleotide polymorphisms (SNPs) were determined by PCR-SSP technique using commercial primers. Our single centre results were compared with the data from literature and combined in cumulative analysis employing the Mantel-Haenszel method. In univariate analysis, only IL-10 ACC genotype tended to prevail in our (Polish) group of patients. None of IL-6 genotypes or IL-10 (-1082) alleles was found to associate with MM disease either in our single centre or in cumulative study. Among patients who died within 36 months of diagnosis, a significant prevalence (P < 0.05) of IL-6 heterozygous cases as opposed to IL-6 homozygotes was observed. IL-6 and IL-10 promoter gene polymorphisms were not found to associate with the susceptibility to the development of MM. However, the IL-6 polymorphic features appeared as factors that might affect the survival of MM patients. The latter observation warrants further study. 相似文献