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121.
Identification, isolation, and characterization of daintain (allograft inflammatory factor 1), a macrophage polypeptide with effects on insulin secretion and abundantly present in the pancreas of prediabetic BB rats
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Zheng-Wang Chen Bo Ahren Claes-Gran
stenson Antonio Cintra Tomas Bergman Christer Mller Kjell Fuxe Viktor Mutt Hans Jrnvall Suad Efendic 《Proceedings of the National Academy of Sciences of the United States of America》1997,94(25):13879-13884
A bioactive macrophage factor, the polypeptide daintain/allograft inflammatory factor 1 (AIF1), has been isolated from porcine intestine. It was discovered when searching for intestinal peptides with effects on insulin release, and its purification was monitored by the influence of the peptide fractions on pancreatic glucose-induced insulin secretion. Daintain/AIF1 is a 146-aa residue polypeptide with a mass of 16,603 Da and an acetylated N terminus. An internal 44-residue segment with the sequence pattern –KR–KK–GKR– has a motif typical of peptide hormone precursors, i.e., dibasic sites for potential activation cleavages and at the sequentially last such site, the structure GKR. The latter is a signal for C-terminal amide formation in the processing of peptide hormones. Daintain/AIF1 is immunohistochemically localized to microglial cells in the central nervous system and to dendritic cells and macrophages in several organs. A particularly dense accumulation of daintain/AIF1-immunoreactive macrophages was observed in the insulitis affecting the pancreatic islets of prediabetic BB rats. When injected intravenously in mice, daintain/AIF1 at 75 pmol/kg inhibited glucose (1 g/kg)-stimulated insulin secretion, with a concomitant impairment of the glucose elimination, whereas at higher doses (7.5 and 75 nmol/kg), daintain/AIF1 potentiated glucose-stimulated insulin secretion and enhanced the glucose elimination. Its dual influence on insulin secretion in vivo at different peptide concentrations, and the abundance of macrophages expressing daintain/AIF1 in the pancreatic islets of prediabetic rats, suggest that daintain/AIF1 may have a role in connection with the pathogenesis of insulin-dependent diabetesmellitus. 相似文献
122.
Ng VL; Hurt MH; Fein CL; Khayam-Bashi F; Marsh J; Nunes WM; McPhaul LW; Feigal E; Nelson P; Herndier BG 《Blood》1994,83(4):1067-1078
Two B-cell lines, 2F7 and 10C9, were established by single cell cloning from biopsies obtained from two acquired immune deficiency syndrome patients with Burkitt's lymphoma. Representation of the original tumors was verified by demonstration of (1) identical biallelic rearrangement of Ig genes for 2F7 and (2) shared idiotype for 10C9. Both cell lines displayed cell-surface Ig and secreted Ig (IgM lambda for 2F7, IgM kappa for 10C9). IgMs from both cell lines immunoprecipitated actin; in addition, 2F7 IgM lambda immunoprecipitated recombinant human immunodeficiency virus type 1 (HIV-1) gp 160. 2F7 IgM lambda did not react with other autoantigens (double-stranded and single-stranded DNA, actin, bovine serum albumin, IgG), whereas 10C9 IgM kappa reacted with human IgG. The 2F7 IgM heavy-chain variable region (VH) showed a 95% nucleotide homology with a previously sequenced VHIII germline gene, hv3019b9, whereas the 10C9 IgM VH showed a 95% homology with a previously sequenced VHIV germline gene, VH4.21. Use of minimally modified VH genes and demonstration of reactivity with chronically present antigens (ie, actin, HIV-1 gp 160, or human IgG) suggests that B cells in HIV-1-infected individuals proliferating in response to chronic antigenic stimulation may be at increased risk for lymphomagenesis. 相似文献
123.
Jamie L. Marshall Benjamin R. Doughty Vidya Subramanian Philine Guckelberger Qingbo Wang Linlin M. Chen Samuel G. Rodriques Kaite Zhang Charles P. Fulco Joseph Nasser Elizabeth J. Grinkevich Teia Noel Sarah Mangiameli Drew T. Bergman Anna Greka Eric S. Lander Fei Chen Jesse M. Engreitz 《Proceedings of the National Academy of Sciences of the United States of America》2020,117(52):33404
124.
Management of recurrent and persistent metastatic lymph nodes in well‐differentiated thyroid cancer: A multifactorial decision‐making guide for the thyroid cancer care collaborative
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Mark L. Urken MD Mira Milas MD Gregory W. Randolph MD Ralph Tufano MD Donald Bergman MD Victor Bernet MD Elise M. Brett MD James D. Brierley MD Rhoda Cobin MD Gerard Doherty MD Joshua Klopper MD Stephanie Lee MD PhD Josef Machac MD Jeffrey I. Mechanick MD Lisa A. Orloff MD Douglas Ross MD Robert C. Smallridge MD David J Terris MD Jason B Clain BS Michael Tuttle MD 《Head & neck》2015,37(4):605-614
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Ambrosi A Salomonsson S Eliasson H Zeffer E Skog A Dzikaite V Bergman G Fernlund E Tingström J Theander E Rydberg A Skogh T Öhman A Lundström U Mellander M Winqvist O Fored M Ekbom A Alfredsson L Källberg H Olsson T Gadler F Jonzon A Kockum I Sonesson SE Wahren-Herlenius M 《Annals of the rheumatic diseases》2012,71(3):334-340
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