全文获取类型
收费全文 | 7742篇 |
免费 | 538篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 158篇 |
儿科学 | 252篇 |
妇产科学 | 153篇 |
基础医学 | 1051篇 |
口腔科学 | 448篇 |
临床医学 | 566篇 |
内科学 | 1702篇 |
皮肤病学 | 167篇 |
神经病学 | 573篇 |
特种医学 | 188篇 |
外科学 | 1197篇 |
综合类 | 27篇 |
一般理论 | 2篇 |
预防医学 | 678篇 |
眼科学 | 232篇 |
药学 | 482篇 |
中国医学 | 49篇 |
肿瘤学 | 378篇 |
出版年
2023年 | 48篇 |
2022年 | 110篇 |
2021年 | 222篇 |
2020年 | 151篇 |
2019年 | 199篇 |
2018年 | 274篇 |
2017年 | 179篇 |
2016年 | 195篇 |
2015年 | 227篇 |
2014年 | 307篇 |
2013年 | 365篇 |
2012年 | 578篇 |
2011年 | 560篇 |
2010年 | 334篇 |
2009年 | 238篇 |
2008年 | 439篇 |
2007年 | 418篇 |
2006年 | 396篇 |
2005年 | 379篇 |
2004年 | 368篇 |
2003年 | 361篇 |
2002年 | 262篇 |
2001年 | 188篇 |
2000年 | 203篇 |
1999年 | 186篇 |
1998年 | 46篇 |
1997年 | 42篇 |
1996年 | 43篇 |
1995年 | 46篇 |
1994年 | 36篇 |
1993年 | 29篇 |
1992年 | 93篇 |
1991年 | 84篇 |
1990年 | 87篇 |
1989年 | 54篇 |
1988年 | 72篇 |
1987年 | 61篇 |
1986年 | 57篇 |
1985年 | 57篇 |
1984年 | 35篇 |
1983年 | 25篇 |
1982年 | 19篇 |
1981年 | 17篇 |
1979年 | 24篇 |
1975年 | 15篇 |
1974年 | 18篇 |
1973年 | 17篇 |
1972年 | 15篇 |
1970年 | 13篇 |
1969年 | 13篇 |
排序方式: 共有8303条查询结果,搜索用时 31 毫秒
91.
92.
This is a prospective interventional clinical study evaluating intraocular inflammation developed after Ultrasound Cyclo Plasty (UCP) for the treatment of glaucoma. Eighteen eyes of 18 patients were treated with UCP second-generation probes (Eye OP1). After treatment, the mean intraocular pressure (IOP) significantly decreased from 26.8±7.2 to 18.8±6.1 mm Hg at day 1 and to 14.7±3.4 mm Hg at month 6 (all P<0.001). Mean laser flare-cell photometry value steeply increased after surgery from 12.1±7.5 to 64.1±53.9 ph/ms (P=0.001) at day 1, and then progressively decreased to respectively 60.6±49.7 at day 7, 43.5±38.5 at day 14 and 28.2±18.3 at month 1 (all P<0.05), returning at levels similar to baseline ones at month 3 and month 6 (respectively 16.7±6.2 and 12.8±10.2, both P>0.05). A significant negative correlation was found between postoperative increase of aqueous flare values and anterior chamber depth (R=-0.568, P=0.014). This timeframe may be considered reasonable for repeating UCP treatment, when required. 相似文献
93.
Karla Palma Portes André de Campos Duprat Carmen Lucia Penteado Lancellotti Leonardo Silva Flávia Coelho de Souza 《Revista brasileira de otorrinolaringologia (English ed.)》2012,78(1):51-56
Fibrin sealants or fibrin glue are products made from human plasma proteins, which mimic the final pathway of the coagulation cascade. Its application to stimulate the healing process has been a topic of debate in the literature. The use of fibrin sealants in phonosurgery has been empirical; there have been no studies that investigate the action of fibrin sealant in Reinke's space.AimTo evaluate the effect of fibrin glue in healing of the vocal folds of pigs after surgical manipulation.Materials and MethodsThis was a prospective and experimental study. Six animals had both vocal folds incised. Sealant was applied in one of them; the other served as a control. After three months, the animals were sacrificed and a collagen count was carried out.ResultsThe side on which glue was applied had an average of 27.8% against 20.4% of the side without glue.ConclusionThe collagen concentration in the samples where the fibrin sealant was applied was significantly higher compared to samples without glue. Thus, the presence of a fibrin sealant stimulates fibrogenesis in this tissue. 相似文献
94.
95.
Coexistence of benign phyllodes tumor and invasive ductal carcinoma in distinct breasts: case report
Guerino Barbalaco Neto Claudia Rossetti Natalia A Souza Fernando LA Fonseca Ligia Ajaime Azzalis Virginia Berlanga Campos Junqueira Vitor E Valenti Luiz Carlos de Abreu 《European journal of medical research》2012,17(1):8
This report describes a rare case of coexistence of benign phyllodes tumor, which measured 9 cm in the right breast, and invasive ductal carcinoma of 6 cm in the left breast, synchronous and independent, in a 66-year-old patient. The patient underwent a bilateral mastectomy due to the size of both lesions. Such situations are rare and usually refer to the occurrence of ductal or lobular carcinoma in situ when associated with malignant phyllodes tumors, and more often in ipsilateral breast or intra-lesional. 相似文献
96.
A long-term comparison was done between the manufacturer-stated 192Ir activity and the measured 192Ir activities determined with a well-type ionization chamber. Sources for a Nucletron Micro Selectron high-dose-rate (HDR) unit were used for this purpose. The radioactive sources reference activities were determined using a PTW well-type ionization chamber traceable to the National Institute of Standards and Technology Primary Calibration Laboratory. The measurements were taken in a period of 56 months with 17 different radioactive sources. The manufacturer stated activities were taken from the source calibration certificate provided by the manufacturer. These values were compared with the measured activities. The results have shown that both the percentage deviation of the monthly control measurements with the well-type chamber and the ratio between the measured activities to the manufacturer-stated value lie within ± 2.5%. These results were compared with similar published data and with uncertainty level (3% of the mean and 5% maximum deviation from mean) for brachytherapy sources calibration recommended by the AAPM. It was concluded that a threshold level of ±2.5% can be used as a suitable quality assurance indicator to spot problems in our department. The typical ±5% uncertainty as provided by the manufacturers may be tightened to ±3% to be more in line with published AAPM reports. 相似文献
97.
Genetic Analysis of PARK2 and PINK1 Genes in Brazilian Patients with Early-Onset Parkinson's Disease
Karla Cristina Vasconcelos Moura Mário Campos Junior Ana Lúcia Zuma de Rosso Denise Hack Nicaretta Jo?o Santos Pereira Delson José Silva Flávia Lima dos Santos Fabíola da Costa Rodrigues Cíntia Barros Santos-Rebou?as Márcia Mattos Gon?alves Pimentel 《Disease markers》2013,35(3):181-185
Parkinson''s disease is the second most frequent neurodegenerative disorder in the world, affecting 1-2% of individuals over the age of 65. The etiology of Parkinson''s disease is complex, with the involvement of gene-environment interactions. Although it is considered a disease of late manifestation, early-onset forms of parkinsonism contribute to 5–10% of all cases. In the present study, we screened mutations in coding regions of PARK2 and PINK1 genes in 136 unrelated Brazilian patients with early-onset Parkinson''s disease through automatic sequencing. We identified six missense variants in PARK2 gene: one known pathogenic mutation, two variants of uncertain role, and three nonpathogenic changes. No pathogenic mutation was identified in PINK1 gene, only benign polymorphisms. All putative pathogenic variants found in this study were in heterozygous state. Our data show that PARK2 point mutations are more common in Brazilian early-onset Parkinson''s disease patients (2.9%) than PINK1 missense variants (0%), corroborating other studies worldwide. 相似文献
98.
99.
100.
Cristina Maria de Souza Conrado de Oliveira Gamba Cecília Bonolo de Campos Miriam Teresa Paz Lopes Mônica Alves Neves Diniz Ferreira Silvia Passos Andrade Geovanni Dantas Cassali 《Pathology, research and practice》2013
Carboplatin is commonly used to treat a variety of tumors. We investigated the effects of carboplatin (100 mg/kg) in the development and metastatic dissemination of the 4T1 mice mammary carcinoma. Carboplatin was able to reduce tumor volume and the number of lung metastases in 50% compared to the control animals. Mitotic and apoptotic indices were also decreased by the treatment. Assessment of the vascularization of the tumors revealed a significant decrease in blood vessel formation by carboplatin. A decrease in nuclear positivity of CDC47 and cyclin D1 was observed in the group treated with carboplatin when compared to the control group. Positivity for p53 was observed in the control group (2/28; 5%) and the treated group (5/71; 4%). Carboplatin has been demonstrated to be an efficient regulator of 4T1MMT growth and dissemination. The action of this chemotherapeutic agent seems to be related to the induction of apoptosis and inhibition of angiogenesis and cell proliferation. 相似文献