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Chronic lymphocytic leukaemia is a disease with a variable clinical course and prognosis. New prognostic factors like immunoglobulin gene mutational status, cytogenetic abnormalities, CD38 and ZAP70 expression of malignant cells have been described recently. Conventional and biological prognostic factors allow to identify patients with unfavorable prognosis at early stage. Purin analogues, fludarabine and fludarabine based combinations can achieve complete hematological remission in approximately one third of patients with chronic lymphocytic leukaemia. Chemoimmunotherapy (most experience is obtained by combination of fludarabine + cyclophosphamide + rituximab) can increase not only complete remission rate, but also induce molecular remission in some cases. Stem cell transplantation as well as early and effective chemotherapy are curative choices of treatment in patients with chronic lymphocytic leukaemia. 相似文献
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瞬目反射对Bell氏麻痹预后判断的作用 总被引:1,自引:0,他引:1
目的:观察Bel氏麻痹患者瞬目反射(BR)的特点,探讨其判断预后的临床意义。方法:检测36例Bel氏麻痹患者及30名健康人BR,并对32例患者进行随访。结果:BR反应电位潜伏期患者均较健康人延长,波幅较健康人低;在临床恢复过程中波幅,潜伏期有恢复趋势;病情预后差者潜伏期比预后好者延长更明显,波幅比预后好者下降更明显。结论:BR检测对估计Bel氏麻痹预后有判断价值。 相似文献
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Esophageal perforation is a rare major complication of fiberoptic endoscopic injection sclerotherapy for bleeding esophageal varices. This complication occurred in 1% (two) of our patients. Both patients recovered with conservative treatment. Although mild symptoms continued for a long period after the procedure, esophageal stenosis did not occur. 相似文献
46.
危重症护理技术协作网络的构建 总被引:5,自引:0,他引:5
为了提高医院的危重症患者的护理质量和抢救成功率及生命质量。采用前瞻性的实践方法构建了护理技术协作网络。通过组织危重症患者的护理技术培训、查房与会诊和扩大危重症护理技术协作网范围、将量化手段引入管理,还应用重症病人评估积分网络管理病人,应用危重症护理技术训练测评系统管理护理人员,提高了护理人员的素质,使人力资源得到合理配置,促进了医疗质量和两个效益的明显提高。由此不难看出,危重症护理技术协作网络有应用推广价值。 相似文献
47.
A decade of experience with TCu200 总被引:1,自引:0,他引:1
This paper summarizes ten years of experience with 2766 interval insertions of the TCu200 device. One hundred and twenty months of use were completed by 572 patients and the cumulative woman-months of use were 159 664. For evaluating the overall performance, gross cumulative and yearly specific life-table termination and continuation rates were calculated as suggested by Tietze [2]. The cumulative pertinent rates at the end of the ten-year follow-up period were as follows: pregnancy 10.2; expulsion 6.3; bleeding/pain 32.3; and removal for other medical reasons 19.4. The gross annual rates for the same conditions at the end of the first year of use were: 1.8, 2.4, 4.2, and 2.0, while in the tenth year they were: 0.6, 0.1, 4.4, and 2.8, respectively. The continuation rate was 89.1 at the end of the 12th month and 33.2 at the end of the 10th year. Based on this evaluation, the TCu200 IUD has a good overall performance and a longer lifespan than was previously expected. 相似文献
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The association of biliary and pancreatic anomalies with periampullary duodenal diverticula. Correlation with clinical presentations 总被引:1,自引:0,他引:1
E Shemesh E Friedman A Czerniak L Bat 《Archives of surgery (Chicago, Ill. : 1960)》1987,122(9):1055-1057
Fifty-eight symptomatic patients with periampullary duodenal diverticula (PDD) were examined for pancreatic and biliary anomalies using endoscopic retrograde cholangiopancreatography (ERCP), ultrasonography, and other imaging modalities. The pathologic findings in these patients were compared with those in a matched group of 58 patients without PDD, who were simultaneously undergoing a similar investigation for the same clinical presentations. Pathologic findings in the pancreas and/or biliary tree were detected in 70.7% of all patients with PDD, compared with 39.7% in the control group. In patients with PDD, pancreatobiliary anomalies were detected in all patients who presented with jaundice, 85% of patients with pancreatitis, and 27.8% of patients with abdominal pain, as compared with 60%, 40%, and 17%, respectively, in the control group. In 23 patients, ERCP findings demonstrated pancreatobiliary abnormalities that were not detected by other imaging modalities. Fifteen of the patients with PDD and pancreatobiliary anomalies had undergone cholecystectomy between six months and five years previously. We conclude that ERCP is essential in the investigation of all patients with PDD, especially those presenting with jaundice or pancreatitis. Biliary surgery in patients with PDD and a dilated bile duct should include a biliary drainage procedure to prevent recurrence of pancreatobiliary disease. 相似文献
50.
【目的】观察穴位埋线疗法对慢性萎缩性胃炎(CAG)模型大鼠胃黏膜的影响。【方法】将90只SD大鼠随机分为空白对照组、模型组、埋线组、针刺组,后3组采用20 mmol/L去氧胆酸钠、0.5~1.0 g/L氨水、0.5 g/L吲哚美辛和体积分数40%酒精等综合方法复制大鼠CAG模型。埋线组选取足三里、中脘、胃俞穴进行穴位埋线,每2周治疗1次;针刺组取穴同埋线组,每天治疗1次,2组共治疗12周。治疗结束后观察穴位埋线对模型大鼠体质量、胃液量、胃液游离酸、总酸度、总酸排量的影响,并在光学显微镜下观察各组胃黏膜的病理形态。【结果】治疗结束后,空白对照组、针刺组、埋线组体质量与模型组比较差异均有显著性意义(P0.05);空白对照组、针刺组和埋线组的胃液量、游离酸度、总酸度及总酸排量均高于模型组(P0.05);针刺组和埋线组胃黏膜病理形态均有明显改善。【结论】穴位埋线疗法对CAG的治疗作用可能与其能促进胃液分泌、改善胃黏膜病理形态变化有关。 相似文献