Tissue-specific inhibition of cell proliferation in Ehrlich's ascites tumor

Extract of Ehrlich's ascites tumor cells (chalone) and its cell-free fluid have a marked inhibitory action on proliferation of these tumor cells 4 h after injection. The effect is tissue specific, it is more marked in the extract, and it depends on the dose of the agent. Mitotic activity in the tumor 8 h after injection of the extract or cell-free fluid is higher than in the control, evidence of a short-term effect of the chalone on the G₂ phase of the mitotic cycle and on synchronization of cell division.Department of General Biology and Genetics, Medico-Biological Faculty, N. I. Pirogov Second Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Kupriyanov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 12, pp. 1477–1479, December, 1976.     

Action of cell extract of Ehrlich's mouse ascites tumor on mitotic activity and DNA synthesis in that tumor

An extract of cells of Ehrlich's ascites tumor inhibits the proliferative activity of its cells tissue specifically. The effect is expressed as a marked decrease in the number of dividing and DNA-synthesizing cells after injection of the extract. The mitotic index falls considerably as early as 2 h after the injection, reaches a minimum after 4–5 h, and returns to the control level again after 9–12 h. The radioactive index is on the whole uniformly low during the 18 h of the experiment.Department of General Biology and Genetics, Medico-Biological Faculty, N. I. Pirogov Second Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Kupriyanov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 7, pp. 86–88, July, 1977.     

A new integrative weaning index of discontinuation from mechanical ventilation

Introduction  

Indexes predicting weaning outcome are frequently inaccurate. We developed a new integrative weaning index aimed at improving the accuracy of the traditional indexes.     

Bitemporal Scalp,Lip and Tongue Necrosis in Giant Cell Arteritis: A Rare Presentation

A 74-year-old man was presented with fever, bilateral throbbing temporoparietal headache, jaw claudication, and bilateral loss of vision. On examination, he had bilateral scalp necrosis with impending necrosis of lip and tongue. Temporal artery biopsy was done, and it was compatible with active temporal arteritis. This is one of the rare presentations of giant cell arteritis where there is simultaneous necrosis of scalp, lip, and tongue, and to the best of our knowledge, it is the first case reported from India.     

How large is the lung recruitability in early acute respiratory distress syndrome: a prospective case series of patients monitored by computed tomography

Introduction  

The benefits of higher positive end expiratory pressure (PEEP) in patients with acute respiratory distress syndrome (ARDS) have been modest, but few studies have fully tested the "open-lung hypothesis". This hypothesis states that most of the collapsed lung tissue observed in ARDS can be reversed at an acceptable clinical cost, potentially resulting in better lung protection, but requiring more intensive maneuvers. The short-/middle-term efficacy of a maximum recruitment strategy (MRS) was recently described in a small physiological study. The present study extends those results, describing a case-series of non-selected patients with early, severe ARDS submitted to MRS and followed until hospital discharge or death.