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111.
VC Carrard AN Haas PV Rados MS Filho RV Oppermann JM Albandar C Susin 《Oral diseases》2011,17(2):171-179
Oral Diseases (2011) 17 , 171–179 Objective: The objective of the study was to assess the prevalence of oral mucosal lesions (OML) and to perform a multivariable risk assessment of demographic, socioeconomic, behavioral, and oral risk indicators for its occurrence in an urban population in South Brazil. Methods: This cross‐sectional study selected 1586 subjects (719M/867F, age: 14–104 years) using a multistage probability sampling strategy (65.1% response rate). Prevalence, odds ratios (OR), and confidence intervals (95% CI) were calculated accounting for the survey design. Results: Leukoplakia and lichen planus were observed in 1.01% and 1.02% of subjects, respectively. In the multivariable analysis, these lesions were significantly associated with moderate/heavy smoking (OR = 9.0, 95% CI = 2.1–39.1) and heavy drinking (OR = 2.0, 95% CI = 1.1–3.7). Candidiasis and proliferative lesions were observed in 14.09% and 3.80% of the subjects, respectively. These lesions were significantly associated with female gender (OR = 2.2, 95% CI = 1.5–3.2 and OR = 1.7, 95% CI = 1.0–2.8), older age (OR = 22, 95% CI = 8.0–60.8 and OR = 8.9, 95% CI = 3.4–23.7), and low socioeconomic status (OR = 1.9, 95% CI = 1.0–3.5 and OR = 3.0, 95% CI = 1.2–7.2). Conclusions: This population is in need of OML prevention and treatment. Future studies should validate the findings that premalignant lesions are causally related to smoking and alcohol consumption, and that other OML are associated with socioeconomic‐demographic disparities in this and similar populations. 相似文献
112.
Pandey V Prabhu JS Payal K Rajan V Deepak C Barde S Jagannath P Borges A Sridhar TS 《International journal of colorectal disease》2007,22(7):777-782
Aim The purpose of the present study was to evaluate the frequency of microsatellite instability (MSI) in colorectal cancers in
an Indian cohort.
Materials and methods Paraffin embedded tissue samples of colorectal cancers from 46 patients were assessed for mismatch repair protein expression
(hMLH1 and hMSH2) by immunohistochemistry. Subsequently, MSI analysis was done after PCR amplification of five Bethesda markers.
Results Amongst 46 cases studied, only 5 patients (10.8%) showed MSI. Out of these, two (4.3%) had high microsatellite instability
(MSI-H) and three (6.5%) showed low microsatellite instability (MSI-L). Out of 46 cases, 41 were microsatellite stable (MSS).
In the 46 cases tested by immunohistochemistry, 7 (15.7%) showed the absence of hMLH1 and 1 case showed the absence of hMSH2.
Conclusion Our study indicates a similar rate of incidence of MSI in colorectal cancers in the Indian cohort compared to the West (10–15%)
despite lower incidence of colorectal cancers and predominance of rectosigmoid tumors in the Indian population. 相似文献
113.
Nicholson JR Peter JC Lecourt AC Barde YA Hofbauer KG 《Journal of neuroendocrinology》2007,19(12):974-982
In the present study, we aimed to investigate the neuromodulatory role played by hypothalamic brain-derived neurotrophic factor (BDNF) in the regulation of acute cardiovascular and feeding responses to melanocortin-4 receptor (MC4R) activation. In vitro, a selective MC4R agonist, MK1, stimulated BDNF release from isolated rat hypothalami and this effect was blocked by preincubation with the MC3/4R antagonist SHU-9119. In vivo, peripheral administration of MK1 decreased food intake in rats and this effect was blocked by pretreatment with an anti-BDNF antibody administered into the third ventricle. When anorexia was induced with the cannabinoid-1 receptor (CB1R) antagonist AM251, the anti-BDNF antibody did not prevent the reduction in food intake. Peripheral administration of MK1 also increased mean arterial pressure, heart rate and body temperature. These effects were prevented by pretreatment with the anti-BDNF antibody whereas the intracerebroventricular administration of BDNF caused changes similar to those of MK1. These findings demonstrate for the first time that activation of MC4R leads to an acute release of BDNF in the hypothalamus. This release is a prerequisite for MC4R-induced effects on appetite, body temperature and cardiovascular function. By contrast, CB1R antagonist-mediated anorexia is independent of the MC4R/BDNF pathway. Overall, these results show that BDNF is an important downstream mediator of the MC4R pathway. 相似文献
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118.
Shehadeh I Rebala S Kumar R Markert RJ Barde C Gopalswamy N 《The American journal of gastroenterology》2002,97(5):1143-1147
OBJECTIVE: Miss rates of large polyp/cancer during colonoscopy are reported from tertiary centers where experts do the colonoscopies. This information is important for determining surveillance intervals for repeat colonoscopy, patient safety, and malpractice issues. We evaluated retrospectively the miss rates of advanced adenomas in the setting of a GI fellowship training where most colonoscopies are done by closely supervised fellows. METHODS: We reviewed the 235 patients who had at least one repeat colonoscopy after initial polypectomy, between 1992 and 1999, at the Dayton Veterans Affairs Medical Center. Advanced adenomas were defined as polyps 10 mm or greater in size with or without a villous component or high-grade dysplasia. Data of missed advanced adenomas on 122 patients who had complete colonoscopy with satisfactory preparation and the excluded patients are reported. RESULTS: Four advanced adenomas (one had intramucosal cancer) on second colonoscopy and two advanced adenomas on third colonoscopy were missed. The miss rate of advanced adenoma for 232 patients was 1.7%, and the miss rate for the 122 patients with complete colonoscopy and satisfactory colon preparation was 2.5% and 3.3% on second and third repeat colonoscopy, respectively. No cancer was missed. CONCLUSIONS: The present study shows an advanced polyp miss rate that is comparable with other studies even in a fellowship training setting. Prospective studies with tandem surveillance colonoscopy are needed to confirm our findings. 相似文献
119.
Csaba Ádori Laura Glück Swapnali Barde Takashi Yoshitake Gabor G. Kovacs Jan Mulder Zsófia Maglóczky László Havas Kata Bölcskei Nicholas Mitsios Mathias Uhlén János Szolcsányi Jan Kehr Annica Rönnbäck Thue Schwartz Jens F. Rehfeld Tibor Harkany Miklós Palkovits Stefan Schulz Tomas Hökfelt 《Acta neuropathologica》2015,129(4):541-563
120.
ObjectiveThe aim of the present investigation was to evaluate the ulcer healing properties of different extracts of Origannum majorana, viz., hydrodistilled volatile oil (OMO), methanolic (OMM) and aqueous extract (OMW) in streptozotocin-nicotinamide induced diabetic rats.MethodsAll the extracts were administered in different doses (100, 200 and 400 mg/kg, p.o.) to investigate the ulcer healing potential. Streptozotocin (STZ; 65 mg/kg, i.p.) along with nicotinamide (120 mg/kg, i.p.) was used to induce non-insulin dependent diabetes mellitus in rats. Aspirin (200 mg/kg, i.p.) was administered for initial 7 d to induce gastric ulcerations in the diabetic rats. Various biochemical markers of blood and tissue origin were estimated to compare the ulcer healing potential of these extracts.ResultsThe OMO and OMM exhibited dose dependent significant (P<0.01) ulcer healing property than the OMW. Additionally, the antidiabetic property of OMO and OMM was better than OMW.ConclusionThe OMO and OMM of Origanum majorana leaves can prove to be beneficial in the concomitant treatment of gastric ulcers and diabetes. 相似文献