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排序方式: 共有3599条查询结果,搜索用时 19 毫秒
71.
This study investigated whether bone marrow mesenchymal stem cell(BMSC) transplantation protected ischemic cerebral injury by stimulating endogenous erythropoietin. The model of ischemic stroke was established in rats through transient middle cerebral artery occlusion. Twenty-four hours later, 1 × 106 human BMSCs(h BMSCs) were injected into the tail vein. Fourteen days later, we found that h BMSCs promoted the release of endogenous erythropoietin in the ischemic region of rats. Simultaneously, 3 μg/d soluble erythropoietin receptor(s EPOR) was injected into the lateral ventricle, and on the next 13 consecutive days. s EPOR blocked the release of endogenous erythropoietin. The neurogenesis in the subventricular zone was less in the h BMSCs + s EPOR group than in the h BMSCs + heat-denatured s EPOR group. The adhesive-removal test result and the modified Neurological Severity Scores(m NSS) were lower in the h BMSCs + s EPOR group than in the heat-denatured s EPOR group. The adhesive-removal test result and m NSS were similar between the h BMSCs + heat-denatured s EPOR group and the h BMSCs + s EPOR group. These findings confirm that BMSCs contribute to neurogenesis and improve neurological function by promoting the release of endogenous erythropoietin following ischemic stroke. 相似文献
72.
Mi Ji Lee Hye Min Jang Woo Kyo Jeong Oh Young Bang 《JOURNAL OF CLINICAL NEUROLOGY》2015,11(4):395-397
Background
Dabigatran etexilate, a new oral anticoagulant, was recently approved as an efficacious alternative to warfarin for the prevention of first and recurrent stroke in patients with nonvalvular atrial fibrillation. Limited data are available for dabigatran use in patients with a creatinine clearance rate (CrCL) of 15-30 mL/min. Furthermore, current guidelines do not recommend frequent blood monitoring after dabigatran use. We report herein a patient with severe renal dysfunction who exhibited profound coagulopathy after 2 days of dabigatran use.Case Report
An 87-year-old woman was admitted for altered mental status and left-side weakness. She was diagnosed with right middle cerebral artery infarction. The baseline assessment revealed a serum creatinine concentration of 1.29 mg/dL and a CrCL of 27.2 mL/min. Dabigatran therapy was started 5 weeks after admission at a dosage of 110 mg twice daily. After 2 days of dabigatran use, the patient developed multiple bruises and evidence of upper-gastrointestinal bleeding. Laboratory tests demonstrated a severe coagulopathy, with a prothrombin time of 85.9 sec, an international normalized ratio of 11.36, an activated partial thromboplastin time of 119.2 sec, and a thrombin time of 230.8 sec. Serial assessment of the patient''s renal function revealed substantial fluctuation of the CrCL (range, 17.9-26.5 mL/min).Conclusions
The present case emphasizes the need for frequent checking of renal function and assessment using coagulation assays after commencing dabigatran therapy in patients with moderate-to-severe renal impairment. 相似文献73.
Dong Hyun Kim Jae Hee Cho Su Hyun Lee Hyun Ki Kim Seung Min Bang Si Young Song Jae Bock Chung Seung Woo Park 《Taehan Sohwagi Hakhoe chi》2008,51(2):142-146
Compared with other types of cancers, pancreatic cancer is one of the most dreadful malignancies and is fifth leading cause of cancer-related death in Korea. It is difficult to expect early diagnosis or improvement in prognosis due to lack of specific early symptoms and effective diagnostic methods. Whereas cystic neoplasm of the pancreas is a rare type of pancreatic tumor, surgical resection provides good prognosis because of its low possibility of local invasion or distant metastasis. In case of pancreatic cystic tumor, radiologic differentiation between benign and malignant lesions is crucial for the selection of appropriate treatment and the prediction of prognosis. And ductal adenocarcinoma of pancreas presenting in cystic form is an uncommon type of cystic tumor, making it extremely rare among all pancreatic malignancies. We report two cases of atypical pancreatic ductal adenocarcinoma presenting as solid pseudopapillary tumor and intraductal papillary mucinous neoplasm, respectively. 相似文献
74.
Dae-Hyouk Bang Hyun-Jeong Noh Hyuk-Shin Cho 《Journal of Physical Therapy Science》2015,27(4):1191-1193
[Purpose] This study aimed to investigate the effects of body awareness training (BAT) on
mild visuospatial neglect in patients following acute stroke. [Subjects] The subjects were
12 stroke patients randomly assigned to either the experimental group (n1=6) or
control group (n2=6). [Methods] The experimental group underwent BAT for 15
minutes and then task-oriented training for 30 minutes a day, five times a week for three
weeks. The control group underwent task-oriented training for 30 minutes a day, five times
a week for three weeks. Assessments were made using the Motor-free Visual Perception Test
(MVPT), Line Bisection Test (LBT), and modified Barthel index (MBI). [Results] Following
the interventions, the experimental group showed a significant change in MVPT, LBT, and
MBI scores. [Conclusion] The results of this study suggest the feasibility and suitability
of BAT with task-oriented training for mild visuospatial neglect in patients with acute
stroke.Key words: Body awareness training, Neglect, Stroke 相似文献
75.
Dae-Hyouk Bang Won-Seob Shin Sung-Jin Choi Ho-Suk Choi 《Journal of Physical Therapy Science》2015,27(4):1203-1206
[Purpose] The purpose of this study was to investigate the knee joint proprioception in
weight-bearing (WB) and non-weight-bearing (NWB) positions and to study the difference
between the methods in chronic stroke patients. [Subjects and Methods] The subjects were
15 stroke patients who were randomly scheduled to perform both positions by a physical
therapist not involved in the study. The subjects performed the positions (WB and NWB)
based on a randomized controlled cross-sectional design. WB subjects were positioned in
one-leg standing to assess the knee joint position sense. NWB subjects were instructed to
sit comfortably in a chair and maintain the knees at 90° of flexion with the leg out of
the plinth. [Results] The results revealed that the WB position showed a significant
difference in knee position sense. The proprioception sense in the WB position was a
higher than that in the NWB position. [Conclusion] The knee proprioception of chronic
stroke patients differs between the weight-bearing and non-weight-bearing positions.Key words: Knee proprioception, Stroke, Weight bearing 相似文献
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79.
Mendes de Leon CF Bang W Bienias JL Glass TA Vaccarino V Kasl SV 《Archives of internal medicine》2005,165(7):763-768
BACKGROUND: Disability in older adults is thought to occur primarily as a consequence of clinical disease episodes. However, the temporal relationship between clinical disease and disability has received little systematic attention. METHODS: Data from a prospective population-based study of 2812 older adults were analyzed to examine changes in disability before and after acute myocardial infarction. Disability outcomes included up to 9 yearly assessments of disability in activities in daily living, disability in basic physical functions, and disability in tasks requiring basic mobility and strength. RESULTS: A total of 279 myocardial infarctions occurred during 9 years of follow-up. After adjustment for age and sex, the average yearly increase in disability in activities of daily living and basic physical functions was not significantly greater in the 1-year period after myocardial infarction than in the 3-year period before myocardial infarction (P values >.20). Disability in basic mobility and strength showed a significantly greater increase in the year after myocardial infarction (P = .02). The results did not change after adjustment for comorbidity and chest pain or when restricted to incident cases of myocardial infarction or survivors. An additional exploratory analysis suggested that the rate of increase in some forms of disability may start to accelerate at about 1 year before the event, rather than after the event. CONCLUSIONS: The increase in disability after myocardial infarction may form a continuation of increases that occur before the event and challenge commonly held notions about the temporal relationship between clinical disease and disability. Changes in disability before acute disease episodes may be related to subclinical disease. 相似文献
80.
Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis 总被引:5,自引:0,他引:5
Thwaites GE Lan NT Dung NH Quy HT Oanh DT Thoa NT Hien NQ Thuc NT Hai NN Bang ND Lan NN Duc NH Tuan VN Hiep CH Chau TT Mai PP Dung NT Stepniewska K White NJ Hien TT Farrar JJ 《The Journal of infectious diseases》2005,192(1):79-88
BACKGROUND: Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to 1 or more antituberculosis drugs is an increasingly common clinical problem, although the impact on outcome is uncertain. METHODS: We performed a prospective study of 180 Vietnamese adults admitted consecutively for TBM. M. tuberculosis was cultured from the cerebrospinal fluid (CSF) of all patients and was tested for susceptibility to first-line antituberculosis drugs. Presenting clinical features, time to CSF bacterial clearance, clinical response to treatment, and 9-month morbidity and mortality were compared between adults infected with susceptible and those infected with drug-resistant organisms. RESULTS: Of 180 isolates, 72 (40.0%) were resistant to at least 1 antituberculosis drug, and 10 (5.6%) were resistant to at least isoniazid and rifampicin. Isoniazid and/or streptomycin resistance was associated with slower CSF bacterial clearance but not with any differences in clinical response or outcome. Combined isoniazid and rifampicin resistance was strongly predictive of death (relative risk of death, 11.63 [95% confidence interval, 5.21-26.32]) and was independently associated with human immunodeficiency virus infection. CONCLUSIONS: Isoniazid and/or streptomycin resistance probably has no detrimental effect on the outcome of TBM when patients are treated with first-line antituberculosis drugs, but combined isoniazid and rifampicin resistance is strongly predictive of death. 相似文献