全文获取类型
收费全文 | 795篇 |
免费 | 38篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 43篇 |
妇产科学 | 7篇 |
基础医学 | 87篇 |
口腔科学 | 9篇 |
临床医学 | 36篇 |
内科学 | 94篇 |
皮肤病学 | 22篇 |
神经病学 | 155篇 |
特种医学 | 91篇 |
外科学 | 47篇 |
综合类 | 17篇 |
预防医学 | 22篇 |
眼科学 | 13篇 |
药学 | 88篇 |
肿瘤学 | 69篇 |
出版年
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 10篇 |
2020年 | 13篇 |
2019年 | 17篇 |
2018年 | 25篇 |
2017年 | 20篇 |
2016年 | 26篇 |
2015年 | 15篇 |
2014年 | 20篇 |
2013年 | 32篇 |
2012年 | 29篇 |
2011年 | 32篇 |
2010年 | 18篇 |
2009年 | 19篇 |
2008年 | 30篇 |
2007年 | 39篇 |
2006年 | 40篇 |
2005年 | 53篇 |
2004年 | 41篇 |
2003年 | 38篇 |
2002年 | 19篇 |
2001年 | 27篇 |
2000年 | 26篇 |
1999年 | 25篇 |
1998年 | 18篇 |
1997年 | 16篇 |
1996年 | 15篇 |
1995年 | 17篇 |
1994年 | 9篇 |
1993年 | 19篇 |
1992年 | 9篇 |
1991年 | 6篇 |
1990年 | 7篇 |
1989年 | 9篇 |
1988年 | 12篇 |
1987年 | 11篇 |
1986年 | 8篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1973年 | 4篇 |
1972年 | 3篇 |
1971年 | 3篇 |
排序方式: 共有834条查询结果,搜索用时 15 毫秒
61.
62.
Ojha T Bakshi M Chakraborti AK Singh S 《Journal of pharmaceutical and biomedical analysis》2003,31(4):775-783
Stress degradation studies were carried out on three piperazinyl quinazoline alpha(1)-adrenergic receptor blockers, viz. prazosin, terazosin, and doxazosin, following the conditions prescribed in the parent drug stability testing guideline (Q1AR) issued by International Conference on Harmonization (ICH). All drugs showed significant decomposition at 80 degrees C in acidic conditions (0.1 M HCl) and complete degradation in alkaline conditions (0.1 M NaOH). Under both these conditions, 2-piperazinyl-6,7-dimethoxy-4-aminoquinazoline was formed as a major decomposition product in all three drugs. The degradation pattern under ICH-prescribed photolytic conditions in liquid and solid states was also similar for all the drugs. The light exposure resulted in the formation of a cluster of degradation products. No degradation was observed in neutral and oxidative conditions. In solid state, all drugs were stable at 50 degrees C in a 1-month study. In alkaline conditions, the order of sensitivity to degradation of the three drugs was doxazosin>terazosin>prazosin, while the same was terazosin>doxazosin>prazosin under acidic conditions. Mechanistic explanation is provided for the variable behaviour of decomposition. 相似文献
63.
Gamma-linolenic acid therapy of human gliomas 总被引:3,自引:0,他引:3
Bakshi A Mukherjee D Bakshi A Banerji AK Das UN 《Nutrition (Burbank, Los Angeles County, Calif.)》2003,19(4):305-309
OBJECTIVES: We investigated the effect of intratumoral administration of gamma-linolenic acid (GLA) in human gliomas. METHODS: We evaluated the effect of the administration of 1 mg of GLA for 7 d via a cerebral reservoir placed into the tumor bed or by direct intratumoral delivery in nine patients who had grade 4 disease and recurrent glioma after surgery, radiation, or chemotherapy. RESULTS: There was some, but not dramatic, improvement in patients' survival. No significant prolongation of life span was expected considering the advanced nature of the disease. Nevertheless, it was encouraging that GLA produced no significant side effects in any patient. Regression of the cerebral gliomas was visualized on computed tomography and magnetic resonance imaging. CONCLUSIONS: Based on results of the present and previous studies, we believe that GLA is a safe antitumor agent and that higher doses of GLA should be investigated in future studies. 相似文献
64.
Pai VR Mazumdar AT Deshmukh CD Bakshi AV Parikh DM Parikh PM Mistry RC Pathak KA 《Medical oncology (Northwood, London, England)》2003,20(1):1-5
Advanced head and neck cancer is a major therapeutic problem in India. Ifosfamide has shown significant activity as a single
agent in head and neck squamous carcinoma. In this study, we present our experience with two cycles of ifosfamide and cisplatin
in the neoadjuvant setting given to a total of 519 patients. The complete response rate was 20% and the overall response rate
was 80%. The treatment was well tolerated, there was no need for dose reduction, and there were no life-threatening side effects.
We feel that this high response rate is sufficient to warrant more studies using ifosfamide-based combinations in a neoadjuvant
setting for squamous carcinoma of the head and neck. 相似文献
65.
Deep gray matter damage may be an important component of the multiple sclerosis (MS) disease process. We tested whether caudate atrophy occurs in MS, and whether it correlates with conventional MRI or clinical markers of disease progression. Caudate nuclei of 24 MS patients and 10 age-matched healthy controls were traced, normalized, reconstructed and visualized from MRI scans. Normalized bicaudate volume was 19% lower in MS controls ( p< 0.001), an effect that persisted after adjusting for whole-brain atrophy ( p< 0.008). Caudate volume did not correlate with disease duration, physical disability score, whole-brain atrophy, or total T2 hyperintense or T1 hypointense lesion load (all p > 0.05). We conclude that selective caudate atrophy is associated with MS and may occur through direct mechanisms. 相似文献
66.
67.
Genetic approaches used for in-vivo studies of bacterial pathogenesis are providing insights into how bacteria disrupt host defences and exploit host molecules for their own advantage. Signature tagged mutagenesis (STM) provides a means of identifying the genes involved in the process of infection, particularly those genes that are important for bacterial proliferation in-vivo. In this review, the application of STM to the understanding of bacterial pathogenesis and findings from work on three human pathogens, Salmonella typhimurium, Mycobacterium tuberculosis and Neisseria meningitidis, are discussed. The next challenge is to understand how these and other genes influence the infective process at the molecular and cellular levels and to design novel interventions to block the progression of disease. 相似文献
68.
69.
Radiologically guided balloon catheters were used to dilate 94 gastrointestinal strictures in 92 patients over a 6-year period. Fifty strictures were esophageal and 44 nonesophageal (22 gastroenterostomies, 11 antral-pyloric strictures, four colorectal strictures, four enteroenterostomies, and three miscellaneous strictures). Factors influencing the success of stricture intubation included patient age, stricture location (esophageal vs. nonesophageal and proximal vs. distal esophageal), and association with a surgical anastomosis. Malignancy was associated with greater postdilation irregularity and a smaller increase in stricture diameter, as measured radiographically. Procedural failures occurred in 8% of cases (2% of esophageal and 30% of nonesophageal lesions). Two small, asymptomatic mucosal tears were seen after dilation (one esophageal and one colonic); no other procedural complications occurred. Following successful dilation, 16 patients (17%; six with esophageal and ten with non-esophageal strictures) had recurrence of symptoms during short-term (30-day) follow-up. 相似文献