全文获取类型
收费全文 | 1527篇 |
免费 | 80篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 93篇 |
妇产科学 | 103篇 |
基础医学 | 121篇 |
口腔科学 | 42篇 |
临床医学 | 165篇 |
内科学 | 320篇 |
皮肤病学 | 45篇 |
神经病学 | 24篇 |
特种医学 | 145篇 |
外科学 | 112篇 |
综合类 | 135篇 |
预防医学 | 93篇 |
眼科学 | 10篇 |
药学 | 91篇 |
1篇 | |
中国医学 | 75篇 |
肿瘤学 | 36篇 |
出版年
2021年 | 15篇 |
2020年 | 10篇 |
2018年 | 12篇 |
2017年 | 18篇 |
2016年 | 15篇 |
2015年 | 33篇 |
2014年 | 42篇 |
2013年 | 42篇 |
2012年 | 49篇 |
2011年 | 46篇 |
2010年 | 54篇 |
2009年 | 44篇 |
2008年 | 44篇 |
2007年 | 33篇 |
2006年 | 36篇 |
2005年 | 16篇 |
2004年 | 18篇 |
2003年 | 12篇 |
2002年 | 11篇 |
2001年 | 21篇 |
1999年 | 19篇 |
1998年 | 43篇 |
1997年 | 54篇 |
1996年 | 47篇 |
1995年 | 42篇 |
1994年 | 55篇 |
1993年 | 35篇 |
1992年 | 15篇 |
1991年 | 14篇 |
1990年 | 14篇 |
1989年 | 28篇 |
1988年 | 27篇 |
1987年 | 30篇 |
1986年 | 25篇 |
1985年 | 16篇 |
1984年 | 16篇 |
1983年 | 16篇 |
1982年 | 13篇 |
1981年 | 23篇 |
1980年 | 16篇 |
1977年 | 9篇 |
1959年 | 35篇 |
1958年 | 58篇 |
1957年 | 87篇 |
1956年 | 45篇 |
1955年 | 75篇 |
1954年 | 67篇 |
1953年 | 17篇 |
1952年 | 14篇 |
1949年 | 10篇 |
排序方式: 共有1620条查询结果,搜索用时 0 毫秒
31.
目的探讨子宫内膜微创术对不孕症妇女体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法选择2010年1月-2012年6月在新疆医科大学第一附属医院生殖助孕中心74例接受IVF-ET/卵胞浆内单精子注射(ICSI)的不孕症患者,以采用子宫内膜微创术的41例患者作为治疗组,在促排周期月经来潮24h内进行子宫内膜微创术;以未进行子宫内膜微创术的33例为对照组,比较两组的胚胎种植率及临床妊娠率。结果治疗组与对照组胚胎种值率分别26.51%和11.43%,差异有统计学意义(P<0.05);治疗组与对照组临床妊娠率分别为43.90%和21.21%,差异有统计学意义(P<0.05)。结论不孕症妇女进行子宫内膜微创术后能够显著提高IVF-ET/ICSI周期的胚胎种植率及临床妊娠率,改善妊娠结局。 相似文献
32.
目的 探讨米非司酮对雌激素受体α(ERα)和孕激素受体(PR)在不同月经周期的子宫腺肌症中表达的影响.方法 47例行全子宫切除术的子宫腺肌症患者分为米非司酮组(n=24)和未用药组(n=23);无腺肌症的正常子宫内膜作为对照组(n=15).运用免疫组化的方法测定异位和在位子宫内膜及正常子宫内膜在不同月经周期的腺上皮及间质细胞中ERα和PR水平.结果 未用药组ERα和PR在异位子宫内膜腺上皮及间质细胞中的表达均低于在位内膜及对照组正常内膜(P<0.05).对照组及未用药组ERα和PR在在位内膜腺上皮细胞中的表达,增生期高于分泌期(P<0.05),而在未用药组异位内膜,差异无统计学意义(P>0.05).ERα和PR在异位和在位子宫内膜中的表达,米非司酮组低于未用药组(P<0.05).结论 ERα和PR在异位子宫内膜中的表达与在位子宫内膜不同;异位内膜丧失了正常内膜的周期性变化规律;米非司酮通过下调其性激素受体(ERα和PR)含量治疗子宫腺肌症. 相似文献
33.
Coexistence of benign phyllodes tumor and invasive ductal carcinoma in distinct breasts: case report
Guerino Barbalaco Neto Claudia Rossetti Natalia A Souza Fernando LA Fonseca Ligia Ajaime Azzalis Virginia Berlanga Campos Junqueira Vitor E Valenti Luiz Carlos de Abreu 《European journal of medical research》2012,17(1):8
This report describes a rare case of coexistence of benign phyllodes tumor, which measured 9 cm in the right breast, and invasive ductal carcinoma of 6 cm in the left breast, synchronous and independent, in a 66-year-old patient. The patient underwent a bilateral mastectomy due to the size of both lesions. Such situations are rare and usually refer to the occurrence of ductal or lobular carcinoma in situ when associated with malignant phyllodes tumors, and more often in ipsilateral breast or intra-lesional. 相似文献
34.
Global vascular expression of murine CD34, a sialomucin-like endothelial ligand for L-selectin 总被引:19,自引:2,他引:19
Extravasation of leukocytes into organized lymphoid tissues and into sites of inflammation is critical to immune surveillance. Leukocyte migration to peripheral lymph nodes (PLN), mesenteric lymph nodes (MLN) and Peyer's patches (PP) depends on L-selectin, which recognizes carbohydrate-bearing, sialomucin-like endothelial cell surface glycoproteins. Two of these ligands have been identified at the molecular level. One is the potentially soluble mucin, GlyCAM 1, which is almost exclusively produced by high endothelial venules (HEV) of PLN and MLN. The second HEV ligand for L-selectin is the membrane-bound sialomucin CD34. Historically, this molecule has been successfully used to purify human pluripotent bone marrow stem cells, and limited data suggest that human CD34 is present on the vascular endothelium of several organs. Here we describe a comprehensive analysis of the vascular expression of CD34 in murine tissues using a highly specific antimurine CD34 polyclonal antibody. CD34 was detected on vessels in all organs examined and was expressed during pancreatic and skin inflammatory episodes. A subset of HEV-like vessels in the inflamed pancreas of nonobese diabetic (NOD) mice are positive for both CD34 and GlyCAM 1, and bind to an L-selectin/immunoglobulin G (IgG) chimeric probe. Finally, we found that CD34 is present on vessels of deafferentiated PLN, despite the fact that these vessels are no longer able to interact with L-selectin or support lymphocyte binding in vitro or trafficking in vivo. Our data suggest that the regulation of posttranslational carbohydrate modifications of CD34 is critical in determining its capability to act as an L-selectin ligand. Based on its ubiquitous expression, we propose that an appropriately glycosylated form of vascular CD34 may act as a ligand for L-selectin-mediated leukocyte trafficking to both lymphoid and nonlymphoid sites. 相似文献
35.
36.
37.
Andrea LA?TOVKOVá Pavlina KLUSá?KOVá Zdenka FENCLOVá Vincent BONNETERRE Daniela PELCLOVá 《Industrial health》2015,53(6):562-568
The objective of this study is to describe a case-series of potassium aluminium
tetrafluoride (KAlF4)-induced occupational asthma (OA) and/or occupational
rhinitis (OR). The study involves five patients from a heat-exchanger production line who
were examined (including specific inhalation challenge tests) for suspected OA and/or OR
caused by a flux containing almost 100% KAlF4 − with fluorides’ workplace air
concentrations ranging between 1.7 and 2.8 mg/m3. No subject had a previous
history of asthma. All five patients had a positive specific challenge test (three
patients were diagnosed with OA alone, one with OR and one with both OR and OA). At the
follow-up visit, after three years on average, all patients needed permanent
corticosteroid therapy (four topical, one oral). After elimination from the exposure, only
one of the observed subjects gave an indication of an improvement, two subjects stabilized
and two worsened. Our case series focuses on the correlation between patients’ exposure to
fluorides in air-conditioner production and the subsequent occurrence of OR/OA. Currently,
it is uncertain whether these OR/OA were caused by hypersensitivity or irritation. 相似文献
38.
目的探讨腹腔镜手术对不孕症患者的诊断及治疗价值。方法回顾性分析新疆医科大学第一附属医院2010年9月-2014年5月收治的319例不孕症患者的临床资料,对所有患者行腹腔镜下诊断及相应的手术治疗(包括盆腔粘连分解、输卵管造口术、输卵管灼断术等)。结果 319例患者腹腔镜术中检查与术前子宫输卵管碘油造影结果的符合率为72.1%(230/319),其中有43例术中发现子宫肌瘤,56例术中发现输卵管系膜囊肿,8例患者术中发现子宫内膜异位症,有2例患者诊断为盆腔结核,1例术中发现结肠肌瘤(术前考虑卵巢囊肿),其余为不同程度的盆腔慢性炎症。轻度粘连69例,妊娠21例,宫外孕2例,妊娠率33.33%。中重度粘连250例,其中行灼断术34例,灼断术患者后行体外受精及胚胎移植(IVF-ET),妊娠13例,妊娠率38.23%(13/34)。其余216例,失访3例,妊娠31例,宫外孕3例、妊娠率15.9%。结论腹腔镜对诊断输卵管性不孕及盆腔疾病有重要价值,子宫输卵管造影仅能初级筛查,诊断价值有限。在治疗输卵管粘连梗阻中,腹腔镜的治疗价值有待进一步探讨,临床预后与盆腔炎症的程度有关,应个体化选择手术方案。 相似文献
39.
A New Variant of Hereditary Hemolytic Anemia With Stomatocytosis and Erythrocyte Cation Abnormality 总被引:4,自引:1,他引:4
MILLER DENIS R.; RICKLES FREDERICK R.; LICHTMAN MARSHALL A.; LA CELLE PAUL L.; BATES JONATHAN; WEED ROBERT I. 《Blood》1971,38(2):184-204
A new variant of congenital hemolyticanemia associated with stomatocytosis,reticulocytosis, decreased osmotic fragility, type I autohemolysis and shortened erythrocyte survival without specific splenic sequestration was discoveredin three siblings of Swiss-German ancestry. Increased intracellular sodium(two to three times normal) and slightlydecreased intracellular potassium weredetected. Total sodium efflux was eight-fold greater than normal but total potassium influx was normal and ouabain-sensitive potassium influx was decreased.The ouabain-sensitive sodium efflux:potassium influx ratio was 26:1 ratherthan the 3:2 ratio noted in normal cells.The consanguineous parents, four othersiblings, and 44 other family membershad mild stomatocytosis, reticulocytosis,and, when studied, decreased osmoticfragility, increased autohemolysis, intermediate abnormalities of cation content,cation flux, and moderate shortening oferythrocyte survival. Autosomal dominant inheritance was suggested. Noabnormalities of RBC enzymes, hemoglobin or lipids were observed. No abnormalities of membrane protein weredetected on acrylamide gel. Substratedepletion of these hypermetabolic cellsresulted in intracellular dehydrationwith potassium loss in excess of sodiumgain and decreased deformability. Although the exact nature of the defectresponsible for hemolysis is unknown,this syndrome differs from other hereditary hemolytic anemias associated withstomatocytosis. Submitted on December 21, 1970 Revised on March 16, 1971 Accepted on March 29, 1971 相似文献
40.
目的 对比分析单纯后路内固定+一期经腰椎间孔病椎间病灶清除(TLIF)与经典的前后联合手术在布氏杆菌性脊柱炎患者中的临床疗效及安全性。 方法 对我院2015年1月至2017年12月收治的93例布病性脊柱炎患者的临床资料进行分析。按手术方式分为观察组(45例)和对照组(48例)。对两组患者的基础数据、临床指标、术前术后各项指标水平以及术后并发症、植骨治愈情况。 结果 观察组与对照组基础数据比较,差异无统计学意义(P>0.05)。观察组患者的手术时间、住院天数、术中出血量及术后下床时间均明显低于对照组(P<0.01)。两组患者术后3个月的ODI、VAS、CRP、ESR及Cobb角均明显低于术前(P<0.05);术后3个月,观察组患者的ODI、VAS、CRP、ESR及Cobb角均明显低于对照组(P<0.05)。观察组术后并发症发生率(4.4%)明显低于对照组(25.0%)(Χ2=7.674,P<0.01)。 结论 TLIF治疗布氏杆菌性脊柱炎患者的临床疗效突出,安全性较好,更有利于患者术后身体的恢复。 相似文献