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31.
ALICE PHAN M.D. STÉPHANE DALLE M.D. BRIGITTE BALME M.D. LUC THOMAS M.D. PH.D. 《Pediatric dermatology》2009,26(3):363-364
Abstract: Scabies is a common human parasitic infection in infants and children. But diagnosis pitfalls are frequent in infants, in whom the clinical presentation is usually atypical and different from adults. We report a misleading case of a 5-month-old child, who presented with pruritic brown–red macules of the trunk showing a positive Darier's sign, suggestive of an urticaria pigmentosa. 相似文献
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GILLES MICHEL BRIGITTE LVY MARIE-THRSE CHAUVET JACQUELINE CHAUVET ROGER ACHER 《Chemical biology & drug design》1990,36(3):302-307
Vasotocin-associated neurophysin (MSEL-neurophysin) has been purified from goose neurohypophysis through molecular sieving and high-pressure reverse-phase liquid chromatography (HPLC). The protein has a molecular mass (measured by SDS-polyacrylamide gel electrophoresis) of 17kDa in contrast to 10kDa found for the mammalian MSEL-neurophysins. Complete amino acid sequence (131 residues) has been determined mainly through tryptic or staphylococcal proteinase peptides derived from carboxyamido-methylated neurophysin, isolated by HPLC and microsequenced. N- and C-terminal sequences have been established by Edman degradation or action of carboxypeptidase Y, respectively, applied on the native protein. Goose MSEL-neurophysin is homologous to the two-domain “big” MSEL-neurophysin previously identified in the frog. It appears that in non-mammalian tetrapods, namely birds and amphibians, the proteolytic processing of the pro-vasotocin involves only one cleavage, releasing the hormone moiety and a “big” neurophysin with two domains homologous to mammalian MSEL-neurophysin and copeptin, respectively. Comparison of the avian protein with its mammalian and amphibian counterparts reveals that the first half of the polypeptide chain is evolutionarily much less variable than the second and that the goose protein resembles the frog protein much more than the mammalian one. 相似文献
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The Centre for Behavioural Research in Cancer (CBRC) is one of two research centres housed at the Anti-Cancer Council of Victoria, the other being an epidemiological research centre. The CBRC's main focus for research is in smoking behaviour. A feature of the Centre is its close organisational and professional links with Victoria's large publicly funded smoking prevention programme. This provides opportunities to conduct programme-related research, to influence the nature of tobacco reduction interventions and to evaluate outcomes. 相似文献
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CHRISTINE E. CLAYTON D.L. SACKS BRIDGET M. OGILVIE BRIGITTE A. ASKONAS 《Parasite immunology》1979,1(3):241-249
African trypanosomiasis in mice leads to profound changes in lymphoid tissues. In an attempt to define the nature of the trypanosome stimulus, we have studied the effect of radio-attenuated trypanosomes and their subcellular fractions in vivo. We find that relatively low doses of irradiated Trypanosoma brucei S42 injected into (CBA/H x C57B1/6)F1 mice mimicked the previously reported effects of infective parasites. 2 x 10(7) irradiated trypanosomes caused a greater than two-fold increase in spleen weight accompanied by a roughly 10-fold increase in background plaque forming cells (PFC) to sheep red blood cells (SRBC). The primary response to SRBC was significantly enhanced when priming was carried out on the day of trypanosome injection, but significantly suppressed when carried out 3 days later. Disruption of trypanosomes by freeze-thawing did not destroy their mitogenic or immunosuppressive activities. A membrane fraction collected by high speed centrifugation (150 000 x g) after removal of larger organelles at 12 000 x g retained both mitogenic and suppressive activities. The high speed supernatant lost the ability to enhance background PFC, but still caused partial immunosuppression with a much lower potency than the membrane pellet. Whether immunosuppression and enhanced PFC levels relate to the same parasite product is not clear as yet, but both effects can be ascribed to a membrane fraction of the parasite. 相似文献
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BRANDSTETTER ANNA M. PICARD BRIGITTE GEAY YVES 《Journal of muscle research and cell motility》1997,18(1):57-62
The objectives of the present study were to elaborate an intra-muscular profile of metabolic enzyme equipment, contractile
and morphometric features along the longitudinal axis of m. semitendinosus at various ages throughout the growth phase. Thirty-seven
male Montbeliard cattle, about half of them castrated, were representatively allocated to various slaughter dates, scheduled
at 4, 8, 12 and16 months of age. Samples were collected from proximal, medial and distal locations of m. semitendinosus. Isocitrate
dehydrogenase (aerobic metabolism) and lactate dehydrogenase (anaerobic metabolism) were measured spectrophotometrically.
Contractile muscle type was classified by quantification of myosin heavy chain I isoform proportion using the sensitive enzyme-linked
immunosorbent assay. Mean muscle fibre area was obtained on histologically-stained cross-sections utilizing animage analysis
system. Our results indicated the existence of a regular intra-muscular pattern of muscle fibre traits along the length of
m. semitendinosus, with decreasing glycolytic activities and concomitantly an increase in oxidative capacity towards the distal
extremity. The metabolic characteristics were in good agreement with decreasing cross-sectional muscle fibre areas and the
slow myosin heavy chain I isoform proportion becoming gradually more abundant from proximal to distal regions of the muscle.
Moreover, the observed gradient was found to be closely related to age and diminished with advanced physiological maturity.
At the final slaughter age (16 months) no differences among the distinct portions were detected, m. semitendinosus was longitudinally
homogeneous in all the characteristics studied
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献