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101.
Johannes Breyer Michael Gierth Sanzhar Shalekenov Atiqullah Aziz Julius Schäfer Maximilian Burger Stefan Denzinger Ferdinand Hofstädter Christian Giedl Wolfgang Otto 《World journal of urology》2016,34(5):709-716
Purpose
To determine whether the immunohistochemical markers survivin and E-cadherin can predict progress at initially diagnosed Ta bladder cancer.Methods
We retrospectively searched for every initially diagnosed pTa urothelial bladder carcinoma having been treated at our single-center hospital in Germany from January 1992 up to December 2004. Follow-up was recorded up to June 2010, with recurrence or progress being the endpoints. Immunohistochemical staining and analysis of survivin and E-cadherin of the TURB specimens were performed. Outcome dependency of progression and no progression with immunohistochemical staining was analyzed using uni- and multivariate regression analysis, Kaplan–Meier analysis and uni- and multivariate Cox regression analysis.Results
Overall, 233 patients were included. Forty-two percent of those were tumor free in their follow-up TURBs, 46 % had at least one pTa recurrence and 12 % even showed progress to at least pT1 bladder cancer. Aberrant staining of E-cadherin was found within 71 % of patients with progression in contrast to only 40 % in cases without progression (p = 0.004). Of all progressed patients, 92 % showed overexpression of survivin in their initial pTa specimen compared to 61 % without progression (p = 0.001). Kaplan–Meier analysis revealed aberrant E-cadherin staining to be associated with worse progression-free survival (PFS) (p = 0.005) as well as overexpression of survivin (p = 0.003). In multivariate Cox regression analysis, strong E-cadherin staining was an independent prognosticator for better PFS (p = 0.033) and multifocality (p = 0.046) and tumor size over 3 cm (p = 0.042) were prognosticators for worse PFS.Conclusion
Adding the immunohistochemical markers survivin and E-cadherin could help to identify patients at risk of developing a progressive disease in initial stage pTa bladder cancer.102.
103.
104.
Oncogenic role of JC virus in lung cancer 总被引:1,自引:0,他引:1
Zheng H Abdel Aziz HO Nakanishi Y Masuda S Saito H Tsuneyama K Takano Y 《The Journal of pathology》2007,212(3):306-315
The JC virus (JCV) infects a large proportion of the population world wide and can cause progressive multifocal leucoencephalopathy in the context of immunodeficiency. Recent reports provide evidence that it may also be oncogenic. Here, JCV was examined by targeting its T-antigen in lung carcinomas (n=103) and normal lung tissues (n=18) by nested-PCR followed by Southern blot, real-time PCR, immunohistochemistry, in situ hybridization and in situ PCR. Additionally, expression of Ki-67, caspase-3, beta-catenin, p53, and Rb was analysed by immunohistochemistry on tissue microarrays of lung carcinomas. Copy numbers of JCV were compared with clinicopathological features. Normal lung tissue was positive significantly less frequently, and contained a lower copy number of JCV than lung carcinomas (p<0.05), and copies were lower in lung adenocarcinomas than in squamous, small or large cell carcinomas (p<0.05). In situ PCR and immunolabelling revealed JCV positivity in the nuclei of lung carcinoma cells. The JCV copy number correlated closely with sex, and expression of Ki-67 and membrane beta-catenin (p<0.05), but not with age, tumour size, pleural invasion, lymph node metastasis, expression of caspase-3, cytoplasmic beta-catenin, p53 or Rb, prognosis, smoking or cancer family history (p>0.05). Age and UICC staging were independent prognostic factors for lung carcinoma patients. These data suggest that JCV may be involved in lung carcinogenesis, especially in tumour types other than adenocarcinoma. Lung carcinomas with higher JCV copy numbers display high proliferation and down-regulation of cell adhesion mediated by membrane beta-catenin. 相似文献
105.
Sameena Shah Rabab Zehra Jafri Khalil Mobin Rabeea Mirza Kashmira Nanji Fatima Jahangir Sufian Jawed Patel Muzamil Shabana Ejaz Iman Qaiser Hira Iftikhar Komal Aziz Wajiha Khan Humza S. Maqbool Hassaan Ahmed 《BMC family practice》2018,19(1):198
Background
Nocturnal enuresis (NE) is a common symptom in children worldwide. International Children’s Continence Society (ICCS) defines enuresis as either mono-symptomatic, NE with lower urinary tract symptoms and NE with co-morbid conditions. The objectives of this study were to determine the frequencies and types of NE and associated symptoms and conditions in children aged 5 to 16?years based on ICCS criteria.Methods
A multi-center cross sectional study was conducted between November 2012 and December 2013 in the primary care clinics of four hospitals in Karachi. Children aged five to fifteen years were included through consecutive sampling. Informed consent was obtained from the parents and a pre-coded semi-structured questionnaire was used to obtain the information. Data was entered on SPSS version 20.0 and multivariable logistic regression analysis was used for data analysis.Results
Out of 429 children aged between five and sixteen years, 243(56.9%) were boys and the remaining 186(43.1%) were girls. One hundred and eighty three children (43%) had nocturnal enuresis (NE). Forty four (10.3%), had mono-symptomatic NE, 57(31.1%) had associated lower urinary tract symptoms (NE-LUTS), whereas 30 (16.3%) had NE with a co-morbid condition. Fifty two (28.4%) NE’s had at least one of both LUTS and a co-morbid condition. Out of the 246(57%) non-enuretic’s, 31(12.6%) had a LUTS, 95(38.6%) had a co-morbid condition and 57(23.2%) had at least one of both LUTS and a co-morbid condition. The remaining 63 (25.6%) were symptom free. Increased voiding frequency, urgency, dysuria, suprapubic pain and daytime incontinence were the LUTS significantly associated with NE. Co-morbid conditions significantly associated with NE included constipation, congenital defects, developmental delay, and learning and sleep problems.Conclusion
Although NE can be an only symptom, it is often associated with lower urinary tract symptoms like dysuria, urgency, suprapubic pain, and daytime incontinence. Children presenting with NE often have co-morbid conditions like constipation, urinary tract infection, sleep disorders, and developmental delay. Many children presenting with these conditions as the primary complaint may also have NE. It should be addressed as unrecognized and untreated NE can cause additional morbidity and distress.106.
Point‐of‐care testing facilitates screening and treatment for anaemia in women and children in rural Pakistan 下载免费PDF全文
107.
Mucosal secretion changes during radiotherapy in the oral cavity 总被引:1,自引:1,他引:0
Mucositis in the oral cavity is a serious complication during radiation therapy for head and neck cancer, causing local discomfort
and pain. In severe cases, hospitalization and interruption of radiotherapy may be necessary. The pathogenesis of this mucositis
is not clear. With the purpose of getting more understanding of the pathogenesis of the mucositis, we examined the mucosal
secretion from ten patients during radiotherapy with an imprint technique. In the secretion we studied the cellular composition
and cellular function. In eight of ten treated patients the numbers of granulocytes increased in the secretion after 2 weeks
of radiation therapy. The granulocytes, however, did not show any signs of phagocytosis. The patients all developed mucositis.
We propose that the granulocytes in the secretion might play an important role in the development of mucositis during radiotherapy. 相似文献
108.
Aziz Hassan Segalini Nicole Ahmed Zubair Ahmad Shahzaib Goodman Martin D. Hertl Martin 《World journal of surgery》2022,46(3):524-530
World Journal of Surgery - Guidelines call for cholecystectomy during the index hospitalization for patients with gallstone pancreatitis. Therefore, the study sought to determine the trends for... 相似文献
109.
An Observational Study of Paediatric Preoperative Transfusion Practice in a Resource-Limited Setting
Charuvila Somy Aziz Tasmiah Tahera Davidson Sarah E. Naznin Ummay Sinha Shiuly Ahmed Sabbir Lakhoo Kokila Banu Tahmina 《World journal of surgery》2022,46(3):709-717
World Journal of Surgery - Paediatric anaemia is highly prevalent in low–middle-income countries and can negatively impact postoperative outcomes. Currently, there are no guidelines for the... 相似文献
110.