全文获取类型
收费全文 | 1165篇 |
免费 | 115篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 99篇 |
妇产科学 | 12篇 |
基础医学 | 172篇 |
口腔科学 | 17篇 |
临床医学 | 131篇 |
内科学 | 221篇 |
皮肤病学 | 14篇 |
神经病学 | 36篇 |
特种医学 | 67篇 |
外科学 | 150篇 |
综合类 | 26篇 |
现状与发展 | 1篇 |
预防医学 | 52篇 |
眼科学 | 137篇 |
药学 | 52篇 |
中国医学 | 12篇 |
肿瘤学 | 86篇 |
出版年
2023年 | 5篇 |
2022年 | 24篇 |
2021年 | 61篇 |
2020年 | 34篇 |
2019年 | 31篇 |
2018年 | 33篇 |
2017年 | 32篇 |
2016年 | 30篇 |
2015年 | 42篇 |
2014年 | 46篇 |
2013年 | 50篇 |
2012年 | 75篇 |
2011年 | 63篇 |
2010年 | 52篇 |
2009年 | 56篇 |
2008年 | 43篇 |
2007年 | 48篇 |
2006年 | 55篇 |
2005年 | 52篇 |
2004年 | 36篇 |
2003年 | 46篇 |
2002年 | 26篇 |
2001年 | 20篇 |
2000年 | 14篇 |
1999年 | 19篇 |
1998年 | 26篇 |
1997年 | 21篇 |
1996年 | 27篇 |
1995年 | 21篇 |
1994年 | 16篇 |
1993年 | 8篇 |
1992年 | 8篇 |
1991年 | 12篇 |
1990年 | 17篇 |
1989年 | 22篇 |
1988年 | 17篇 |
1987年 | 18篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1984年 | 9篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1972年 | 2篇 |
1948年 | 2篇 |
排序方式: 共有1289条查询结果,搜索用时 15 毫秒
21.
Hirotsugu Uemura Dingwei Ye Ravindran Kanesvaran Edmund Chiong Bannakij Lojanapiwat Yeong-Shiau Pu Sudhir Kumar Rawal Azad Hassan Abdul Razack Hao Zeng Byung Ha Chung Noor Ashani Md Yusoff Chikara Ohyama Choung Soo Kim Sunai Leewansangtong Yuh-Shyan Tsai Yanfang Liu Weiping Liu Maximiliano van Kooten Losio Marxengel Asinas-Tan 《BJU international》2020,125(4):541-552
22.
Nail involvement is estimated to affect 80–90% of patients with psoriasis at some point in their lives and is often associated with severe disease. Patients with nail involvement experience pain, functional impairment and social stigma, with significant restriction of daily activities and quality of life. Nail psoriasis is also considered a risk factor for the development of psoriatic arthritis (PsA). Management of nail psoriasis is deemed challenging and as a result, it is often left untreated by physicians. Assessing the severity of nail disease can also be difficult in clinical practice. While the Nail Psoriasis Severity Index is used widely in trials, it is time‐consuming and rarely used in the clinic, highlighting the need to develop a simplified disease severity score for nail psoriasis. All patients should be advised to keep their nails short, wear gloves for wet and dirty work, and regularly apply emollient to the nail folds and nail surface. Patients with mild nail psoriasis, without signs of severe cutaneous psoriasis or PsA, may benefit from topical treatment, while systemic treatment is indicated in patients with severe nail involvement. Evidence suggests that all anti‐tumour necrosis factor (TNF)‐α, anti‐interleukin (IL)‐17, and anti‐IL‐12/23 antibodies available for plaque psoriasis and PsA are highly effective treatments for nail psoriasis. This article aims to provide an up‐to‐date review of the therapeutic options currently available for the management of nail psoriasis in patients with or without skin psoriasis. Therapeutic options for the management of nail psoriasis in children will also be discussed. 相似文献
23.
AF Jorm H Christensen AS Henderson PA Jacomb AE Korten A Mackinnon 《Age and ageing》1996,25(2):126-129
Formal assessment of cognitive decline with cognitive tests can be difficult, requiring either two measurement points or a comparison of 'hold' with 'don't hold' tests. Informant-based assessment provides an alternative approach because informants can adopt a longitudinal perspective and directly rate cognitive change. A study was carried out to assess the validity of informant ratings collected by means of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). A community sample of 500 subjects aged 74 or over underwent four cognitive tests on two occasions 3½ years apart. On the second occasion, informants filled out the IQCODE. Subjects rated as having moderate or severe decline were found to have greater change on the cognitive tests. These findings support the validity of informant ratings of cognitive decline. 相似文献
24.
Restriction of cell lysis by homologous complement: II. Protection of erythrocytes against lysis by newly activated complement 总被引:1,自引:0,他引:1
Our previous work revealed that homologous complement (C) was ineffective in lysing antibody-sensitized erythrocytes (EA) even at high concentrations. It was also shown that activation of complement on homologous EA resulted in the binding of C9 and the formation of EA bearing complement proteins C1 through C9 (EAC1-9), yet few hemolytic sites were formed. Instead, as shown here, the formation of homologous EAC1-9 caused the cells to become resistant to lysis even by heterologous complement during a second incubation. In contrast, when homologous EAC1-8 were produced by incubating EA with C9-depleted serum, such intermediates were not protected against lysis by heterologous complement during a second incubation. Furthermore, homologous C9 on EAC1-9 was able to reduce the hemolytic efficiency of heterologous complement without blocking C activation and the formation of new C5b-9 complexes. Protection was not modified when homologous EAC1-9 were produced in one step, by incubation of EA with serum, or sequentially by adding C9 to EAC1-8. The minimum number of 9-sites required to confer a protective effect on EAC1-9 was less than 200 per cell. Thus, in addition to its known effect in heterologous cell killing, homologous C9 is capable of protecting homologous cells against inadvertent complement lysis. 相似文献
25.
Katherine R. Amato Marie-Claire Arrieta Meghan B. Azad Michael T. Bailey Josiane L. Broussard Carlijn E. Bruggeling Erika C. Claud Elizabeth K. Costello Emily R. Davenport Bas E. Dutilh Holly A. Swain Ewald Paul Ewald Erin C. Hanlon Wrenetha Julion Ali Keshavarzian Corinne F. Maurice Gregory E. Miller Geoffrey A. Preidis Laure Segurel Burton Singer Sathish Subramanian Liping Zhao Christopher W. Kuzawa 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(25)
Individuals who are minoritized as a result of race, sexual identity, gender, or socioeconomic status experience a higher prevalence of many diseases. Understanding the biological processes that cause and maintain these socially driven health inequities is essential for addressing them. The gut microbiome is strongly shaped by host environments and affects host metabolic, immune, and neuroendocrine functions, making it an important pathway by which differences in experiences caused by social, political, and economic forces could contribute to health inequities. Nevertheless, few studies have directly integrated the gut microbiome into investigations of health inequities. Here, we argue that accounting for host–gut microbe interactions will improve understanding and management of health inequities, and that health policy must begin to consider the microbiome as an important pathway linking environments to population health. 相似文献
26.
27.
Brijesh Takkar Vinod Kumar Renu Agrawal Raghav Ravani Shorya Azad 《Saudi Journal of Ophthalmology》2015,29(4):315-316
Small intraocular foreign body in the outer coats of the eye may be wrongly interpreted as optic nerve head on ultrasound imaging. Such errors can be avoided by performing multiple sonography scans in different axes. 相似文献
28.
Jila Yavarian Farshid Rezaei Azadeh Shadab Mahmood Soroush Mohammad Mehdi Gooya Talat Mokhtari Azad 《Emerging infectious diseases》2015,21(2):362-364
During January 2013–August 2014, a total of 1,800 patients in Iran who had respiratory illness were tested for Middle East respiratory syndrome coronavirus. A cluster of 5 cases occurred in Kerman Province during May–July 2014, but virus transmission routes for some infections were unclear. 相似文献
29.
R. Bhatnagar Y. R. Sharma R. B. Vajpayee M. Madan V. K. Chhabra N. Ram K. Mukesh R. V. Azad R. Sharma 《Digestive diseases and sciences》1989,34(11):1745-1750
We undertook a prospective study to test Simoons' hypothesis that in certain susceptible races milk exerts a cataractogenic effect. Overall milk intake in low lactase deficiency areas did not correlate with cataract occurrence. Subgrouping of cataract patients revealed that greater milk intake did show positive correlation with cortical cataracts. Cortical cataracts were also markedly more common in females. Analysis of data from three different regions showed greater milk intake in cortical cataract patients only. Our data indicate the importance of specifying cataract type in cataract studies and highlight the problem this approach brings forth. We noted no different trends in subjects from northwest and southeast India, although the number of subjects from the southeast was considerably less. Patients with early cortical cataracts may be advised to restrict milk intake.Part of this material was presented at second cataract epidemiology meeting at Bonn in March 1988. A brief report has been accepted for publication in the proceedings of the meeting to be published inDevelopment of Ophthalmology, Vol. 17, 1988. 相似文献
30.