全文获取类型
收费全文 | 514篇 |
免费 | 29篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 59篇 |
妇产科学 | 12篇 |
基础医学 | 39篇 |
口腔科学 | 29篇 |
临床医学 | 69篇 |
内科学 | 95篇 |
皮肤病学 | 24篇 |
神经病学 | 35篇 |
特种医学 | 15篇 |
外科学 | 54篇 |
综合类 | 17篇 |
预防医学 | 15篇 |
眼科学 | 5篇 |
药学 | 37篇 |
中国医学 | 15篇 |
肿瘤学 | 14篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 12篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 12篇 |
2017年 | 12篇 |
2016年 | 15篇 |
2015年 | 28篇 |
2014年 | 29篇 |
2013年 | 39篇 |
2012年 | 47篇 |
2011年 | 55篇 |
2010年 | 18篇 |
2009年 | 29篇 |
2008年 | 35篇 |
2007年 | 42篇 |
2006年 | 38篇 |
2005年 | 50篇 |
2004年 | 22篇 |
2003年 | 10篇 |
2002年 | 18篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1982年 | 1篇 |
排序方式: 共有544条查询结果,搜索用时 0 毫秒
81.
82.
Objective.— We attempted to investigate the relationship between migraine without aura (MwoA) and bronchial hyper‐reactivity to postulate inflammation as an underlying mechanism in migraine. Background.— Comorbidity of migraine and atopic diseases such as asthma has been an argument for suspected immune system dysfunction in migraineurs. Methods.— Twenty patients with MwoA and 5 control subjects without history of atophy and asthma were included in study. Subjects with abnormal physical examination and chest radiographs were excluded. After a normal spirometry, methacholine bronchoprovocation test was performed in all subjects and controls according to 5 breath dosimeter methods. Results.— Sixteen of 20 patients and 2 of 5 control subjects were women. Mean ages were 37.5 (19‐56) and 33.8 (26‐43) years, respectively. Methacholine bronchoprovocation test was positive in 3 patients (15%) but was normal in all controls (0%). Conclusions.— The relationship between MwoA and bronchial hyper‐reactivity may help to postulate the inflammation in migraine as an underlying mechanism. 相似文献
83.
84.
85.
Bagislar S Ustuner I Cengiz B Soylemez F Akyerli CB Ceylaner S Ceylaner G Acar A Ozcelik T 《The Australian & New Zealand journal of obstetrics & gynaecology》2006,46(5):384-387
BACKGROUND: The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of recurrent spontaneous abortion (RSA) but the results obtained were conflicting. AIMS: We therefore investigated the XCI patterns in peripheral blood DNA obtained from 80 patients who had RSA and 160 age-matched controls. METHODS: Pregnancy history, age, karyotype, and disease information was collected from all subjects. The methylation status of a highly polymorphic cytosine-adenine-guanine repeat in the androgen-receptor (AR) gene was determined by use of methylation-sensitive restriction enzyme HpaII and polymerase chain reaction. RESULTS: Skewed XCI (> 85% skewing) was observed in 13 of the 62 patients informative for the AR polymorphism (20.9%), and eight of the 124 informative controls (6.4%) (P = 0.0069; chi2 test). More importantly, extremely skewed XCI, defined as > 90% inactivation of one allele, was present in 11 (17.7%) patients, and in only two controls (P = 0.0002; chi2 test). CONCLUSIONS: These results support the interpretation that disturbances in XCI mosaicism may be involved in the pathogenesis of RSA. 相似文献
86.
87.
Citak EC Oguz A Karadeniz C Karaoglan B Tan MO Okur V Cansu A 《Journal of pediatric hematology/oncology》2008,30(1):61-62
Vincristine commonly induces peripheral neuropathy but rarely causes voiding dysfunction. In this report, we describe a case of neurogenic bladder and peripheral neuropathy caused by the neurotoxic effect of vincristine and documented by urodynamic testing and electromyography. Neurologic evaluation aided in monitoring and understanding this problem. 相似文献
88.
F. Visal Okur Aynur Oguz Ceyda Karadeniz Caglar Citak Aylar Poyraz Oznur Boyunaga 《Pediatric hematology and oncology》2013,30(1):25-31
The authors describe a 6-year-old boy diagnosed with mediastinal Burkitt lymphoma with tumor invasion into bone marrow and both kidneys. After receiving chemotherapy according to NHL BFM-95 protocol for the high-risk disseminated lymphoma, the patient reached complete remission. He relapsed in the mediastinum at 5 months from the diagnosis. He underwent thoracotomy and tumor mass was removed by inferior lobectomy of right lung. Residual tumor progressed rapidly. Autologous stem cell transplantation could not be performed because of unresponsiveness to cytoreductive chemotherapy. Twenty-three days after the last chemotherapy course, he received rituximab at a dose of 375 mg/m 2 by intravenous infusion weekly, for a total of 8 dose. However, multiple intra-abdominal metastatic lesions were detected at the end of the therapy. Palliative radiotherapy was applied to these sites. He died because of disease progression, 11 months after the diagnosis. 相似文献
89.
F. Güçlü Pınarlı Aynur Oğuz Ceyda Karadeniz Ömer Uluoğlu Nalan Akyürek 《Pediatric hematology and oncology》2013,30(6):543-548
Retinoblastoma is the primary ocular malignancy affecting children under 6 years of age. The development of second malignant tumors in survivors of hereditary retinoblastoma is a well-known clinical entity and a major cause of morbidity and mortality. Rhabdomyosarcomas as second primary tumors have been only rarely described. The authors report a patient with bilateral retinoblastoma who developed a myogenic sarcoma of the orbit after 5.5 years of diagnosis. The short latency period may be explained by tumor histology with the contribution of radiotherapy and chemotherapy. The prognosis of second tumors is poor despite aggressive treatment. 相似文献
90.
Aynur Oguz Ceyda Karadeniz Meltem Pelit Alev Hasanoglu 《Pediatric hematology and oncology》2013,30(1):35-41
Malnutrition in children with cancer is reported to be relatively uncommon at the time of diagnosis. However, in most studies nutritional status measurement has relied almost exclusively on weight-related indices. This can be misleading, because in children with malignancy, tumor masses can reach more than 10% of total body weight. A controlled study was performed in 62 patients using arm anthropometry to provide a more accurate evaluation of the nutritional status of children with cancer at presentation. Height, weight, midupper arm circumference (MUAC), and triceps skinfold thickness (TSFT) were measured in all patients (40 boys, 22 girls) and controls (18 boys, 13 girls). Weight for height (W FH) of each patient was compared with the national standards. MUAC and TSF T were also interpreted according to the standards developed by A. Roberto Frisancho. The mean ages were 6.5 3.7 years (range 0.08-13) and 5.7 4.7 years (range 0.25-15) in patients and control group, respectively. Results showed that although the W FH values for patients were normal, MUAC and TSF T values were significantly less than control values (P < 0.001). Moreover, 27% of patients showed malnutrition (they had MUAC and TSF T below 5th percentile). Patients with intraabdominal solid tumors had significantly lower MUAC and TSF T values than those with extraabdominal solid tumors (P < 0.05). The data strongly indicate that malnutrition is common at the time of diagnosis in children with cancer, and arm anthropometry should replace the use of weight-related indices to identify malnutrition in children. 相似文献