全文获取类型
收费全文 | 2310篇 |
免费 | 106篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 48篇 |
妇产科学 | 34篇 |
基础医学 | 318篇 |
口腔科学 | 59篇 |
临床医学 | 118篇 |
内科学 | 645篇 |
皮肤病学 | 42篇 |
神经病学 | 212篇 |
特种医学 | 66篇 |
外科学 | 437篇 |
综合类 | 19篇 |
预防医学 | 43篇 |
眼科学 | 26篇 |
药学 | 143篇 |
中国医学 | 3篇 |
肿瘤学 | 194篇 |
出版年
2023年 | 22篇 |
2022年 | 32篇 |
2021年 | 42篇 |
2020年 | 30篇 |
2019年 | 42篇 |
2018年 | 52篇 |
2017年 | 28篇 |
2016年 | 45篇 |
2015年 | 41篇 |
2014年 | 56篇 |
2013年 | 59篇 |
2012年 | 90篇 |
2011年 | 151篇 |
2010年 | 91篇 |
2009年 | 62篇 |
2008年 | 105篇 |
2007年 | 100篇 |
2006年 | 108篇 |
2005年 | 116篇 |
2004年 | 101篇 |
2003年 | 116篇 |
2002年 | 100篇 |
2001年 | 103篇 |
2000年 | 99篇 |
1999年 | 100篇 |
1998年 | 28篇 |
1997年 | 18篇 |
1996年 | 20篇 |
1995年 | 12篇 |
1994年 | 11篇 |
1992年 | 46篇 |
1991年 | 30篇 |
1990年 | 33篇 |
1989年 | 47篇 |
1988年 | 32篇 |
1987年 | 33篇 |
1986年 | 33篇 |
1985年 | 23篇 |
1984年 | 15篇 |
1983年 | 14篇 |
1979年 | 12篇 |
1978年 | 11篇 |
1977年 | 10篇 |
1974年 | 6篇 |
1973年 | 6篇 |
1971年 | 10篇 |
1969年 | 8篇 |
1968年 | 9篇 |
1967年 | 8篇 |
1966年 | 11篇 |
排序方式: 共有2426条查询结果,搜索用时 15 毫秒
81.
Kazuo Kobayashi Masao Toyoda Nobuo Hatori Takayuki Furuki Hiroyuki Sakai Tomoya Umezono Shun Ito Daisuke Suzuki Hiroshi Takeda Fuyuki Minagawa Hisakazu Degawa Hareaki Yamamoto Hideo Machimura Keiichi Chin Toshimasa Hishiki Masahiro Takihata Kouta Aoyama Shinichi Umezawa Kohsuke Minamisawa Togo Aoyama Yoshiro Hamada Yoshiro Suzuki Masahiro Hayashi Yutaka Hatori Kazuyoshi Sato Masaaki Miyakawa Kouichi Tamura Akira Kanamori 《Journal of diabetes investigation.》2021,12(1):74-81
Aims/IntroductionSodium–glucose cotransporter 2 inhibitors (SGLT2i) improve renal outcome in patients with type 2 diabetes mellitus, but the mechanism is not fully understood. The aim of this retrospective study was to assess the association of achieved blood pressure with renal outcomes in Japanese type 2 diabetes mellitus patients with chronic kidney disease.Materials and MethodsWe assessed 624 Japanese type 2 diabetes mellitus patients with chronic kidney disease taking SGLT2i for >1 year. The patients were classified as those with post‐treatment mean arterial pressure (MAP) of ≥92 mmHg (n = 344) and those with MAP of <92 mmHg (n = 280) for propensity score matching (1:1 nearest neighbor match with 0.04 of caliper value and no replacement). The end‐point was a composite of progression of albuminuria or a decrease in the estimated glomerular filtration rate by ≥15% per year.ResultsBy propensity score matching, a matched cohort model was constructed, including 201 patients in each group. The incidence of renal composite outcome was significantly lower among patients with MAP of <92 mmHg than among patients with MAP of ≥92 mmHg (n = 11 [6%] vs n = 26 [13%], respectively, P = 0.001). The change in estimated glomerular filtration rate was similar in the two groups; however, the change in the albumin‐to‐creatinine ratio was significantly larger in patients with MAP of <92 mmHg.ConclusionsIn Japanese type 2 diabetes mellitus patients with chronic kidney disease, blood pressure after SGLT2i administration influences the renal composite outcome. Blood pressure management is important, even during treatment with SGLT2i. 相似文献
82.
Keijiro Nakamura Takahito Takagi Norihiro Kogame Hikari Hashimoto Masako Asami Yasutake Toyoda Yoshinari Enomoto Hidehiko Hara Mahito Noro Kaoru Sugi Masao Moroi Masato Nakamura 《Journal of atherosclerosis and thrombosis》2021,28(6):590
Aim: Arterial stiffness results in elevated left ventricular filling pressure and can promote atrial remodeling due to chronic pressure overload. However, the impact of arterial stiffness on the process of atrial remodeling in association with atrial fibrillation (AF) has not been fully evaluated. Methods: We enrolled 237 consecutive patients diagnosed with AF who had undergone ablation; data from 213 patients were analyzed. Cardio-ankle vascular index (CAVI) was used as a marker of arterial stiffness. The left atrial (LA) and right atrial (RA) volumes were determined by computed tomography imaging; atrial conduction and voltage amplitude were evaluated using a three-dimensional electromapping system used to guide the ablation procedure. Result: In univariate analysis, CAVI significantly correlated with atrial structural and electrical remodeling (LA volume index, r =0.297, P =0.001; RA volume index, r =0.252, P =0.004; LA conduction velocity, r =0.254, P = 0.003; LA mean voltage, r =−0.343, P =0.001, RA mean voltage; r =−0.245, P =0.015). Multivariate regression analysis revealed that CAVI and plasma levels of N-terminal B-type natriuretic peptide were independent determinants of LA and RA remodeling, respectively. On the other hand, age and LA conduction velocity were independent variables with respect to CAVI. Age-adjusted CAVI was highest in long-standing persistent AF when compared with measures of persistent or paroxysmal AF. Conclusion: CAVI was closely associated with biatrial remodeling in patients diagnosed with AF. These results suggest that arterial stiffness may play a significant role with respect to disease progression. 相似文献
83.
Yuichi Morishima Yasuyoshi Toyoda Tadaomi Fukada Ichiro Suzuki Yasuo Aoki Yoichi Tazawa Jun Kobayashi Tsuguhiko Tashiro 《Esophagus》2005,2(3):165-168
A 72-year-old man with non-Hodgkin’s lymphoma at the tracheal bifurcation node received combination chemotherapy and subsequently developed a fistula in spite of remission of the lymphoma. Conservative therapy did not heal the fistula formation, and we chose bypass surgery using a gastric tube without thoracotomy. Ten months postoperatively, there is no evidence of lymphoma relapse and the patient lives a normal life. We consider this procedure as an available treatment for esophagobronchial fistula in case of failure to cure fistula communication by conservative therapy. 相似文献
84.
N Toyoda M Nishikawa M Horimoto N Yoshikawa Y Mori M Yoshimura H Masaki K Tanaka M Inada 《Endocrinology》1990,127(3):1199-1205
The effects of T3 and T4 on the iodothyronine 5'-deiodinase (5'-D) activity in FRTL-5 rat thyroid cells were investigated. T3 and T4 stimulated the 5'-D activity in a dose-dependent manner. Kinetic studies showed that the stimulation of the 5'-D by T3 was associated with an increase in maximum velocity (Vmax) in [11.9 +/- 0.2 (mean +/- SE) and 25.4 +/- 0.9 pmol I-released/mg protein.min, respectively, in control and cultured with 10(-9) M T3 for four days] but without a change in apparent Michaelis-Menten constant (Km) (94.8 +/- 5.3 nM and 105.4 +/- 12.1 nM, respectively). Furthermore, cycloheximide (5 microM) completely abolished the stimulatory effect of T3 on the 5'-D activity. T3 and T4 also enhanced the 5'-D activity stimulated by TSH in a dose-dependent manner. Kinetic studies showed that the stimulatory effect of T3 on the 5'-D stimulated by TSH was again associated with an increase in Vmax (86.0 +/- 4.0 and 166.5 +/- 1.9 pmol I- released/mg protein.min, respectively, cultured with 0.3 U/liter TSH and cultured with TSH plus 10(-9) M T3 for four days) without a change in apparent Km (114.0 +/- 7.4 nM and 111.6 +/- 12.5 nM, respectively). Cycloheximide (5 microM) completely abolished the stimulatory effect of TSH plus T3 on the 5'-D activity. There were no significant differences observed between cells cultured with TSH and with TSH plus T3 in either the intra- or extracellular cAMP contents. Furthermore, T3 enhanced the 5'-D activity stimulated by (Bu)2 cAMP. These results strongly suggest that T3 or T4 was synergistic with TSH in stimulating the 5'-D activity in FRTL-5 cells, and that cAMP production would be an important component of the synergism. 相似文献
85.
86.
We report a case of an extrahepatic bile duct metastasis from a gallbladder cancer that mimicked Mirizzi's syndrome on cholangiography. A 67-yr-old woman was admitted to our hospital with a diagnosis of acute calculous cholecystitis. As obstructive jaundice developed after the admission, percutaneous transhepatic biliary drainage was performed to ameliorate the jaundice and to evaluate the biliary system. Tube cholangiography revealed bile duct obstruction at the hepatic hilus, and extrinsic compression of the lateral aspect of the common hepatic duct, with nonvisualization of the gallbladder. No impacted cystic duct stone was visualized on CT or ultrasonography. Laparotomy revealed a gallbladder tumor as well as an extrahepatic bile duct tumor. We diagnosed that the latter was a metastasis from the gallbladder cancer, based on the histopathological features. This case is unique in that the extrahepatic bile duct metastasis obstructed both the common hepatic duct and the cystic duct, giving the appearance of Mirizzi's syndrome on cholangiography. Metastatic bile duct tumors that mimic Mirizzi's syndrome have not been previously reported. The presence of this condition should be suspected in patients with the cholangiographic features of Mirizzi's syndrome, when the CT or ultrasonographic findings fail to demonstrate an impacted cystic duct stone. 相似文献
87.
Moriwaki Y Sugiyama M Uchida K Kosuge T Karube N Toyoda H Yamamoto T Hasegawa S Kanaya K Matsuda G Yamagishi S Yoshida K 《Hepato-gastroenterology》2003,50(54):2117-2120
BACKGROUND/AIMS: To clarify changes in the hepatic oxygen metabolism and tissue damage resulting from oxygen-derived free radical generation from polymorphonuclear cells during a hepatic arterial clamp. METHODOLOGY: Subjects were 32 male Wistar rats. Hepatic tissue blood flow, and hepatic venous chemiluminescence, indicating oxygen-derived free radicals from polymorphonuclear cells, and liver lipid peroxide were measured, and hepatic and portal venous blood gas analysis were performed before and after 130 minutes of hepatic arterial clamping. RESULTS: Hepatic tissue blood flow decreased by hepatic arterial clamp. The values of hepatic arterial oxygen pressure (HTBF), hepatic venous oxygen saturation (ShvO2), and O2 contents after hepatic arterial clamp were lower than those before hepatic arterial clamp (P = 0.035, 0.024, and 0.028, respectively). Hepatic venous chemiluminescence decreased and the lipid peroxide level of the liver increased by hepatic arterial clamp (P = 0.001). CONCLUSIONS: ShvO2 is useful for the evaluation of hepatic oxygen metabolism and hepatic tissue blood flow during acute hepatic arterial clamp. This condition should prepare the following tissue damage due to oxygen-derived free radicals from polymorphonuclear cells. 相似文献
88.
Yuki Yokobori Minoru Toyoda Koichi Sakakura Kyoichi Kaira Yoshito Tsushima 《Acta oto-laryngologica》2015,135(5):494-499
Conclusion: The maximum standardized uptake value (SUVmax) of early oral squamous cell carcinoma (OSCC) may have a role as an imaging biomarker for assessment of malignant potential, including cell metabolism and angiogenesis. Objective: The usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been proven in various cancers, including OSCC. Moreover, in several carcinomas, the SUVmax of the tumor has been shown to correlate with the histological type, tumor stage, differentiation, and prognosis. Here, we investigated whether the SUVmax of early OSCC was associated with the biological features. Methods: Twenty-seven patients with newly diagnosed early OSCC who underwent preoperative FDG-PET and curative surgical resection were included in this study. Tumor sections were stained by immunohistochemistry for glucose transporter 1 (GLUT1), L-type amino acid transporter 1 (LAT1), CD98, microvessels (CD34), cell proliferation marker (Ki-67), and cell cycle regulator (p53). The correlation between SUVmax and clinicopathological findings or the expression level of these molecules was analyzed. Results: SUVmax of primary OSCC was significantly higher in patients with T2 stage. Moreover, patients whose tumors showed vascular invasion had a tendency to show higher SUVmax. A significant correlation was observed between SUVmax and the expression of LAT1 or microvessel density. 相似文献
89.
90.
Tomomi Toyoda Shinya Tosaka Reiko Tosaka Takuji Maekawa Sungsam Cho Susumu Eguchi Masahiro Nakashima Koji Sumikawa 《The Journal of surgical research》2014