全文获取类型
收费全文 | 451篇 |
免费 | 35篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 18篇 |
妇产科学 | 19篇 |
基础医学 | 66篇 |
口腔科学 | 21篇 |
临床医学 | 53篇 |
内科学 | 95篇 |
皮肤病学 | 18篇 |
神经病学 | 52篇 |
特种医学 | 6篇 |
外科学 | 53篇 |
综合类 | 6篇 |
预防医学 | 23篇 |
眼科学 | 14篇 |
药学 | 27篇 |
中国医学 | 5篇 |
肿瘤学 | 9篇 |
出版年
2024年 | 1篇 |
2023年 | 15篇 |
2022年 | 17篇 |
2021年 | 23篇 |
2020年 | 20篇 |
2019年 | 13篇 |
2018年 | 33篇 |
2017年 | 27篇 |
2016年 | 32篇 |
2015年 | 42篇 |
2014年 | 31篇 |
2013年 | 47篇 |
2012年 | 36篇 |
2011年 | 34篇 |
2010年 | 30篇 |
2009年 | 21篇 |
2008年 | 19篇 |
2007年 | 12篇 |
2006年 | 7篇 |
2005年 | 11篇 |
2004年 | 7篇 |
2003年 | 6篇 |
2002年 | 1篇 |
2001年 | 3篇 |
2000年 | 3篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
排序方式: 共有494条查询结果,搜索用时 15 毫秒
61.
Erkingül Shugaiv Asl? K?yat-Atamer Erdem Tüzün Murat Kürtüncü I??n Baral-Kulaks?zo?lu Gül?en Akman Demir 《Medical principles and practice》2013,22(6):550-554
Objective
This study was conducted to characterize the prevalence and clinical features of kleptomania, an impulse control disorder, in patients with Behçet''s disease involving the central nervous system.Subjects and Methods
Medical records of 350 patients with neuro-Behçet''s disease were evaluated, and clinical and neuropsychological features of patients with kleptomania were noted.Results
Of the 350 neuro-Behçet''s disease patients 6 (1.7%) had presented with symptoms that fulfilled the criteria of kleptomania according to the revised 4th version of the Diagnostic and Statistical Manual of Mental Disorders. The 6 patients (5 men, 1 woman) had parenchymal lesions and had developed kleptomania during remission. Magnetic resonance imaging done on the 6 patients before the onset of kleptomania mostly revealed brainstem lesions. Psychiatric assessment did not show any comorbid psychiatric disorders and neuropsychological evaluation showed executive dysfunction in all patients.Conclusion
The 6 patients with kleptomania had developed a frontal lobe syndrome.Key Words: Neuro-Behçet''s disease, Meningoencephalitis, Kleptomania, Impulse control disorder 相似文献62.
63.
Ali Yal??nda? Asl?han Uzun F. Nilüfer Yal??nda? Nam?k Deliba? 《Inflammation research》2012,61(11):1241-1246
Background/aims
To determine serum vitronectin levels in Beh?et patients with and without ocular involvement, and to evaluate the relationship between vitronectin concentrations and clinical manifestations of Beh?et’s disease (BD).Methods
Sixty-five patients with BD and 21 control subjects were included. All patients were queried for the clinical manifestations of BD. Serum vitronectin concentrations were determined by using in vitro enzyme immunoassay kits.Results
Serum vitronectin levels between the patients and the control subjects were not different. There was no statistically significant difference between vitronectin levels in Beh?et patients with and without ocular involvement. No correlation was found between vitronectin concentrations and clinical manifestations.Conclusion
This is the first study evaluating vitronectin levels in Beh?et patients. Further studies involving larger numbers of subjects would be useful to improve our understanding of the functions of vitronectin in BD. 相似文献64.
Salar S Yeni N Gündüz A Güler A Gökçay A Velioğlu S Gündoğdu A Hande Çağlayan S 《Epilepsy research》2012,98(2-3):273-276
Lafora disease (LD) is a type of autosomal recessive, progressive myoclonus epilepsy resulting mostly from mutations in the EPM2A and NHLRC1 genes. Mutational analysis in both genes was initiated with the aim of establishing LD DNA diagnosis in Turkey. Four novel NHLRC1 (p.G131X, p.P69S and p.D82H) and EPM2A (p.V7A) and two recurrent NHLRC1 (p.D146N) and EPM2A (p.R241X) mutations were identified in six families. The delineation of causative mutations in patients provided early disease diagnosis for other family members and contributed to the knowledge of LD pathogenesis. 相似文献
65.
Helda Tutunchi Alireza Ostadrahimi Maryam Saghafi‐Asl Vahid Maleki 《Obesity reviews》2019,20(7):1057-1069
Non‐alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease. Recently, some novel compounds have been investigated for the prevention and treatment of NAFLD. Oleoylethanolamide (OEA), an endogenous PPAR‐α agonist, has exhibited a plethora of pharmacological properties for the treatment of obesity and other obesity‐associated metabolic complications. This systematic review was performed with a focus on the effects of OEA on the risk factors for NAFLD. PubMed, Scopus, Embase, ProQuest, and Google Scholar databases were searched up to December 2018 using relevant keywords. All articles written in English evaluating the effects of OEA on the risk factors for NAFLD were eligible for the review. The evidence reviewed in this article illustrates that OEA regulates multiple biological processes associated with NAFLD, including lipid metabolism, inflammation, oxidative stress, and energy homeostasis through different mechanisms. In summary, many beneficial effects of OEA have led to the understanding that OEA may be an effective therapeutic strategy for the management of NAFLD. Although a wide range of studies have demonstrated the most useful effects of OEA on NAFLD and the associated risk factors, further clinical trials, from both in vivo studies and in vitro experiments, are warranted to verify these outcomes. 相似文献
66.
67.
68.
Giray Bozkaya Ozge Fenercioglu İsmail Demir Aslı Guler Behnaz Aslanipour 《Gynecological endocrinology》2020,36(10):849-853
AbstractNeudesin is a neuropeptide hormone involves in female reproduction system via promoting effects of progesterone. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder associated with hypothalamic-pituitary-ovarian axis abnormalities and impaired negative feedback mechanism of progesterone upon gonadotropin-releasing hormone secretion. Our aims were to discover whether neudesin levels were altered in PCOS women comparing to controls and to determine the link of neudesin with hormonal-metabolic parameters in PCOS women. The current research was designed as a case-control study. Sixty-eight subjects with PCOS and 67 age- and body mass index (BMI)-matched subjects as controls were enrolled into the study. Circulating neudesin levels were measured by ELISA. Neudesin levels were significantly lower in PCOS subjects compared to controls (4.07?±?1.22 vs. 6.02?±?2.07?ng/ml, p?<?.001). Neudesin exhibited an inversely independent link with luteinizing hormone, free-androgen index, and BMI whereas it showed a positively independent link with progesterone in women with PCOS. Logistic regression analysis revealed that decreased neudesin levels were parallel with increased risk of having PCOS. Decreased neudesin levels were associated with hormonal disturbances in PCOS women, suggesting that neudesin may play a role in pathophysiology of PCOS. 相似文献
69.
Korosh Heydari Massoud Saidijam Mohammad reza Sharifi Fatemeh Karimi dermani Sara Soleimani Asl Nooshin Shabab Rezvan Najafi 《Pathology oncology research : POR》2018,24(1):145-151
5-Fluorouracil (5-FU) as a chemotherapeutic drug is used to treat colorectal cancer (CRC). However, 5-FU is associated with acquired CRC resistance, which decreases the therapeutic potential of 5-FU. Several studies indicated that miR-200c is also involved in chemotherapeutic drug resistance, but the exact mechanism of miR-200c mediated chemoresistance has not yet been fully understood. In this study, we examined the effect of inhibition of miR-200c on the sensitivity of HCT-116 cells to 5-FU. HCT-116 cells were transfected with LNA-anti- miR-200c for 48 h. mRNA expression of miR-200c was investigated by qRT-PCR. The protein expression of phosphatase and tensin homolog (PTEN) and E-cadherin were evaluated by western blotting. Annexin V/ PI staining and caspase 3 activity were used to detect apoptosis. LNA-anti-miR-200c inhibited the miR-200c expression in the transfected cells compared with that in the control group. LNA-anti-miR-200c suppressed the expression of PTEN and E-cadherin independent of the presence of the chemotherapeutic drug 5-FU. LNA-anti-miR-200c reduced the 5-FU-induced apoptosis and caspase 3 activity. miR-200c, as a novel prognostic marker in CRC, can be a potential therapeutic approach to overcome chemoresistance during 5-FU chemotherapy. 相似文献
70.
Işın Sinem Bağcı Mehmet Salih Gürel Ayşe Esra Koku Aksu Aslı Turgut Erdemir Esma İnan Yüksel Yeliz Karakoca Başaran 《Lasers in medical science》2017,32(7):1497-1506
Lips display various benign and malignant lesions. Considering their functional and cosmetic importance, noninvasive diagnostic methods are required. In vivo reflectance confocal microscopy (RCM) has already been reported to be useful in the evaluation of various skin lesions. The aim of this study was to define the RCM features of nonmelanocytic lip lesions, compare them with healthy lip, and demonstrate the applicability of RCM as a noninvasive diagnostic method for nonmelanocytic lip lesions. Sixty-seven patients with premalignant/malignant, inflammatory, and infectious lip lesions and twenty-one healthy volunteers were included in the study. Following clinical and RCM examination, histopathological confirmation was obtained in all lesions except herpes labialis, verrucae, and aphthae. RCM features of individual lesions and corresponding groups were evaluated and compared. Pleomorphism was the common feature of premalignant/malignant lesions. Dermal invasion of dyskeratotic keratinocytes was visualized in all squamous cell carcinoma lesions. Spongiosis and inflammatory cells were the common features of inflammatory lesions. Hypergranulosis and necrotic keratinocytes were highly specific for lichen planus. The most specific features for discoid lupus erythematosus were irregular pattern, follicular plugs, and perifollicular inflammatory cells. Virus-infected keratinocytes were visualized in herpes and verrucae. RCM features showed high sensitivity and specificity to detect nonmelanocytic lip lesions. Although the penetration is limited to the papillary dermis in nonmucosal skin, imaging down to the mid-dermis with satisfactory resolution was possible on the lips. 相似文献