Short-term complications after surgically induced abortions: a register-based study of 56 117 abortions

BACKGROUND: Performing an induced abortion is a rather simple medical procedure which is frequently done and side-effects will have public health implications unless they are very rare. We estimated the incidence of side-effects detected during the stay at the hospital and 2 weeks after the discharge. We only include side-effects reported by clinics or hospitals. METHODS: Altogether 56 117 induced abortions performed by public hospitals in Denmark from 1980 to 1994 were analyzed in this study. The study combined results from the mandatory reporting of side-effects to the National Induced Abortion Registry and all diagnoses reported to the Hospital Discharge Registry. RESULTS: Side-effects in the form of bleeding, infections or re-evacuation were recorded for about 5%. We found more side-effects in teenage women and for abortions performed late in pregnancy. We found nothing to indicate that the frequency of side-effects following an abortion changed over time. CONCLUSIONS: About 5% have side-effects registered by hospitals following an induced abortion. The long-term consequences of this are not known.     

Phospholipids reduce adhesion formation in the rabbit uterine horn model

Objective: To access the ability of intraperitoneal phospholipids to reduce adhesions in a standardized model for gynecologic operations.

Design: A randomized, experimental, blinded study using the double uterine horn model.

Setting: Academic animal research laboratory.

Animal(s): Thirty-three Chinchilla rabbits.

Intervention(s): Phospholipids or Ringer’s lactate were intraperitoneally administered after bilateral uterine horn injury.

Main Outcome Measure(s): After 10 days, adhesions were evaluated concerning area and strength as well as scores describing tenacity and degree.

Result(s): Phospholipids (median 102.1 mm²) significantly reduce adhesion areas in comparison to surgical controls (median 392.2 mm²) and Ringer group (median 323.8 mm²). Scores reflecting severity and degree of adhesions support this finding.

Conclusion(s): These results prove the efficacy of phospholipids in the double uterine horn model. Future clinical studies are recommended.     

Activity of enzymes involved in energy production in the small intestine during suckling-weaning transition of pigs

The effect of weaning on a potential metabolic capacity of key enzymes involved in the energy production by porcine enterocytes was investigated. The activity of citrate synthase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, glutamate dehydrogenase, alanine aminotransferase and aspartate aminotransferase was determined in the small intestine epithelium of piglets during suckling-weaning transition. Investigations were performed on 5-week-old (suckling), 6-week-old (1st week after weaning) and 7-week-old (2nd week after weaning) piglets. The activity of glutamate dehydrogenase decreased (p < 0.05) during the 1st week after weaning, and remained numerically lower during the 2nd week after weaning than in suckling piglets. The activities of isocitrate dehydrogenase and alanine aminotransferase showed the same pattern as the glutamate dehydrogenase activity and decreased numerically during the 1st and 2nd weeks. The activities of citrate synthase and alpha-ketoglutarate dehydrogenase were numerically lower in post-weaned piglets (1st and 2nd weeks) than in suckling piglets. In contrast, the activity of aspartate aminotransferase was high and remained unchanged from week 5 to the 2nd week post-weaning. The activities of alanine and aspartate aminotransferase were positively correlated in suckling piglets (r = 0.98, p < 0.05) and at the 1st week after weaning (r = 0.99, p < 0.01). Also, both aminotransferases were positively correlated to the activity of alpha-ketoglutarate dehydrogenase in suckling piglets (r = 0.95, p < 0.05 and r = 0.95, p < 0.05) and to the activity of isocitrate dehydrogenase during the 1st week after weaning (r = 0.99, p < 0.001 and r = 0.99, p < 0.01). The results indicate additional capacity of the tricarboxylic acid (TCA) cycle for transformation of alpha-ketoglutarate from other sources than acetyl-CoA such as glutamine, glutamate and other amino acids. Further, the high activity of aspartate aminotransferase also suggests a high capacity of porcine small intestinal epithelium to provide the TCA cycle with oxaloacetate during the suckling-weaning transition.     

Directivity of different hearing aid microphone locations

In this study, we present a new method to derive a single-number measure of the directivity of hearing aids. The method is an extension of the conventional directivity index (DI), and is called overall directivity index (ODI). The directivities of five different hearing aid styles were compared with that of the open ear. The behind-the-ear (BTE) style showed the lowest directionality compared to the other hearing aid styles and the open ear. There were only minor differences in directivity between any of the four different hearing aid styles placed in the ear and of the open ear canal. The conventional measure of DI is less suitable for hearing aids, because it ignores sound coming from other than the frontal direction. To quantify directionality of a hearing aid in a real-life situation, we suggest the single-number ODI, weighted with the articulation index and related to a listening segment of 0-30 degrees. An application of the data is shown for a BTE with a directional microphone.     

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The expression of EGFR family ligands in breast carcinomas

Expression of EGF, HB-EGF, TGF-alpha, HRG-alpha, HRG-beta1, and HRG-beta3 in 100 frozen breast carcinoma materials was immunohistochemically studied. Among these tumors, 67% were positive for EGF, 53% for HB-EGF, 57% for TGF-alpha, 60% for HRG-alpha, 53% for HRG-beta1, and 63% for HRG-beta3 in the neoplastic epithelial cells. No significant associations between expression of the growth factors and clinicopathological features like tumor size, histologic grade, node status, ploidy, ER status, and c-erbB-4 expression were observed, with the exceptions that significant relations were present between EGF expression and tumor size (p = 0.01) and between HRG-beta3 expression and node status (p = 0.02). The expressions of these growth factors showed no association with cancer-specific survival by the Kaplan Meier analysis.     

Third molar agenesis in Down syndrome

The frequency, gender, and maxillary/mandibular occurrences of third molar agenesis have been studied in a Danish population of Down syndrome individuals (39 F and 31 M). The study was based on radiological examination and compared with 2 control groups of normal Caucasian populations. We found that the occurrence of third molar agenesis in Down syndrome individuals was around 4 times greater than in a normal population and higher than in corresponding previous studies. The agenesis occurred more often in the maxilla than in the mandible, and the frequency was not significantly higher in females than in males. The present study stresses the importance of focusing on the dental germs in the phenotypic discussion, as different genes are involved in tooth formation. The absence of teeth can contribute to an understanding of the interaction between genotype and phenotype.     

Utilization of dental health services among middle-aged people in Sweden and Denmark

In 1999, questionnaires were sent to random samples of 1001 Swedish citizens aged 55-79 years and 1175 Danish citizens aged 45-69 years. Various questions were asked concerning dental conditions, dental visit frequency per year, and money spent annually on dental care, etc. The objectives were to assess differences in the utilization of dental services and to compare out-of-pocket costs for dental care in Sweden and Denmark with control for age, gender, dental conditions and income. More than 80% of the subjects reported that a dentist had examined them less than 1 year previously. However, 77% of the Danes reported dental visits twice a year or more compared to 28% of the Swedes. Although the Danes reported a more frequent use of dental services, they had poorer dental conditions compared to the Swedes. Even though the Swedes used dental services less often than the Danes did, more subjects reported high 12-month out-of-pocket costs. In the present study, separate models were constructed for the two countries because there could be different mechanisms at play, as indicated by the results. The different insurance systems along with different degrees of commercialization in the two countries might be the most decisive factors in this context.