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151.
J. H. Heimdal H. J. Aarstad A. Aakvaag J. Olofsson 《European archives of oto-rhino-laryngology》1997,254(7):318-322
T-lymphocyte cell function was studied in vitro in peripheral blood mononuclear cells (PBMC) from 61 male patients with head
and neck squamous cell carcinomas compared to 46 control patients. Patients older than 80 years or with reduced tumor-related
performance status as measured by Karnofsky score less than 75 were excluded. In contrast to previous similar studies, control
subjects ensured a minimum stress load by sampling all patients on the day of either diagnostic or therapeutic surgery. PBMC
were separated by density-gradient centrifugation and subsequently cultured with autologous sera in vitro. The mitogen concanavalin
A (Con A), which stimulates all T-cell clones, was employed. Findings showed that increased Con A stimulation and PBMC proliferation
occurred with PBMC from cancer patients compared to that from control patients. In contrast, no differences could be detected
with respect to the stimulated supernatant level of interleukin-2, interleukin-4 or interferon-γ between the groups. These
results suggest that T-lymphocytes from PBMC are generally affected by neoplastic disease through either a supporting cell
or serum factor. 相似文献
152.
Bjørn T. Gjertsen Christopher J. Logothetis Timothy J. McDonnell 《Cancer metastasis reviews》1998,17(4):345-351
Many of the common molecular alterations associated with prostate cancer progression involve genes known to regulate cell death susceptibility. The significance of these molecular events is discussed in the context of developing and implementing new strategies designed to restore cell death susceptibility in prostate cancer cells and overcome therapeutic resistance. 相似文献
153.
Astrid K. Wahl Tone Rustøen Berit R. Hanestad Anners Lerdal Torbjørn Moum 《Quality of life research》2004,13(5):1001-1009
The main aim of the present study was to derive norms or reference values from the general Norwegian population for the Norwegian version of the Quality of Life Scale (QOLS-N). In addition, associations between socio-demographic and health variables on the level of quality of life were examined. The sample consisted of 1893 subjects from a total of 4000 randomly selected Norwegian citizens representative of the entire Norwegian population, aged 19-81. The subjects received a mailed questionnaire containing the QOLS-N. Results show that the mean quality of life score was 84.1 (SD 12.5). Women reported a higher quality of life than men. People with higher levels of education reported a higher quality of life. Those who were married or cohabitating reported the highest quality of life and those who were unemployed reported a lower quality of life than those who worked. In addition, people reporting long-term diseases or health problems scored significantly lower on quality of life. These results could serve as reference values for the level of quality of life, as measured by the QOLS-N in the Norwegian population. 相似文献
154.
Osteosarcoma relapse after combined modality therapy: an analysis of unselected patients in the Cooperative Osteosarcoma Study Group (COSS). 总被引:4,自引:0,他引:4
Beate Kempf-Bielack Stefan S Bielack Heribert Jürgens Detlev Branscheid Wolfgang E Berdel G Ulrich Exner Ulrich G?bel Knut Helmke Gernot Jundt Hartmut Kabisch Mathias Kevric Thomas Klingebiel Rainer Kotz Rainer Maas Rudolf Schwarz Michael Semik J?rn Treuner Andreas Zoubek Kurt Winkler 《Journal of clinical oncology》2005,23(3):559-568
PURPOSE: To evaluate the impact of patient, tumor, and treatment-related factors on outcome in unselected patients with recurrent osteosarcoma. PATIENTS AND METHODS: Five hundred seventy-six consecutive patients who had achieved a first complete surgical remission (CR) during combined-modality therapy on neoadjuvant Cooperative Osteosarcoma Study Group (COSS) protocols and then developed recurrent osteosarcoma were analyzed (median time from biopsy to relapse, 1.6 years; range, 0.1 to 14.3 years). There were 501 patients with metastases, 44 with local recurrences, and 31 with both. Metastases involved lungs (469 patients), bones (90 patients), and/or other sites (54 patients). RESULTS: After a median follow-up of 1.2 years for all patients and 4.2 years for survivors, actuarial overall survival (OS) rates at 2, 5, and 10 years were 0.38, 0.23, and 0.18, respectively. Five-year OS was 0.39 for 339 patients with and 0.00 for 229 patients without a second surgical CR (P < .0001). A long time to relapse, a solitary lesion, and, in the case of pulmonary metastases, unilateral disease and the absence of pleural disruption, were of positive prognostic value in uni- and multivariate analyses, as were a second surgical CR and the use of second-line chemotherapy. Radiotherapy was associated with moderately prolonged survival in patients without a second CR. The very limited prognostic differences associated with the use of second-line chemotherapy appeared to be more pronounced with polychemotherapy. CONCLUSION: Time to relapse and tumor burden correlate with postrelapse outcome in osteosarcoma. Complete surgery is an essential component of curative second-line therapy. Chemotherapy, particularly chemotherapy with more than one agent, may contribute to limited improvements in outcome. 相似文献
155.
156.
Patients’ experience of partial tooth loss and expectations to treatment: a qualitative study in Danish and Swedish patients
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Knowledge of impairments, wishes and expectations is essential to make correct decisions regarding oral rehabilitation. The purpose of this study was to investigate discomforts, wishes and expectations in patients’ with partial edentulism before entering oral rehabilitation. In Copenhagen, Denmark, and Malmö, Sweden, respectively, 20 patients with partial edentulism seeking rehabilitation were interviewed in a semistructured qualitative manner. The interviews were transcribed and analysed yielding overall domains. Six themes appeared as overall domains: (i) experienced impairments, (ii) experienced social awareness, (iii) expectation to treatment, (iv) expectation to durability/survival, (v) coping strategies dealing with the tooth loss including explanations of the tooth loss and (vi) modifications to experienced impairment. The impairments were mostly experienced as problems in social settings. Most participants expressed a simple wish to function normally; a fixed solution was preferred. Many Danish participants accepted a removable solution whereas only few Swedish participants did so. The domains ‘coping strategies’ and ‘modifications’ were not part of the chosen topics of interest, indicating a high wish of the participants to explain their tooth loss and how they coped with it. In conclusion, a large degree of social impairment was found in the patient group along with several coping strategies. The impairments were modified by a number of factors indicating that highly individualised care and treatment is needed. A state of normality was described as the primary treatment wish with a higher acceptance of removable solutions in Denmark than in Sweden. For final decision‐making, surrounding factors seemed to influence the patients’ choices. 相似文献
157.
158.
159.
Kaare Solheim Knut A. Evensen Bjørn Høivik Steinar Karlsen Arne R. Rosseland 《Scandinavian cardiovascular journal : SCJ》2013,47(1):61-64
AbstractTwo operated cases of aorto-caval fistula due to ruptured abdominal aneurysm are reported. This is a rare and real surgical emergency and is fatal without operation. The classical symptoms of high-output failure occurring simultaneously with the findings of an expansible abdominal mass with thrill and bruit should facilitate clinical diagnosis. 相似文献
160.
Björn Arnljots Torbjörn Söderström Henry Svensson 《Journal of plastic surgery and hand surgery》2013,47(1):105-108
The surgical management of ulcers in the lower extremity is traditionally conservative, and includes debridement and split thickness skin grafting. In the most intractable cases, however, this management is often not enough. In this report of three patients with non-healing ulcers of the lower extremity successfully treated with free muscle flaps, we advocate a more active surgical approach to the treatment of such conditions. This is also appropriate in patients for whom a microsurgical approach might not be considered because of advanced age, peripheral arterio-occlusive disease, or the presence of other risk factors. 相似文献