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Gökce Orhan MD Merle Bock MSc Dorien Schepers MSc Elena I. Ilina MSc Stephanie Nadine Reichel BSc Heidi Löffler Nicole Jezutkovic Sarah Weckhuysen MD Simone Mandelstam MB ChB Arvid Suls PhD Timm Danker PhD Elke Guenther PhD Ingrid E. Scheffer MBBS PhD Peter De Jonghe MD PhD Holger Lerche MD Snezana Maljevic PhD 《Annals of neurology》2014,75(3):382-394
96.
Tony Hope Janet Keene Kathy Gedling Sandra Cooper Christopher Fairburn Robin Jacoby 《International journal of geriatric psychiatry》1997,12(11):1062-1073
Objective. This article analyses behaviour changes in dementia at the point of entry to a longitudinal study. Design. Prospective, longitudinal study of behaviour in dementia, with autopsy follow-up. Setting. Subjects with dementia, living at home with a carer. All lived in Oxfordshire, UK. Participants. Ninety-seven people with dementia (Alzheimer's disease and/or vascular dementia) who were living at home with a carer. Measures. At 4-monthly intervals, the carers were interviewed and the subjects with dementia were assessed cognitively. Subjects' behaviour was assessed using the Present Behavioural Examination. This is an investigator-based, semi-structured interview consisting of eight main sections covering many different aspects of behaviour. The 121 main questions, with 66 further ‘nested’ questions, have been shown to have high reliability. Results. This article analyses the types of behaviour change reported by carers at the point of entry to this long-term study. Few correlations were found between behaviour and age, gender and time since onset of dementia. Some types of behaviour were significantly more prevalent in those with greater cognitive impairment. Conclusions. Many of these changes create problems for carers, for example increased aggressive behaviour, wandering, wakefulness at night, incontinence and persecutory ideas. In general, they are more prevalent in people with more severe dementia. © 1997 John Wiley & Sons, Ltd. 相似文献
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Arvid Nikolai Kildahl Sissel Berge Helverschou Trine Lise Bakken Hanne Weie Oddli 《Journal of mental health research in intellectual disabilities》2020,13(3):201-230
ABSTRACT
Introduction
Individuals with autism spectrum disorder (ASD) and intellectual disability (ID) seem to be at increased risk for post-traumatic stress disorder (PTSD), but knowledge is sparse regarding its identification in this population. Previous research indicates that certain symptoms of PTSD may be more easily recognized, and that identifying reexperiencing and avoidance is particularly challenging. 相似文献98.
Lene Plhaugen Carole H Sudre Sandra Tecelao Arne Nakling Ina S Almdahl Lisa F Kalheim M Jorge Cardoso Stein H Johnsen Arvid Rongve Dag Aarsland Atle Bjrnerud Per Selnes Tormod Fladby 《Journal of cerebral blood flow and metabolism》2021,41(5):1162
White matter hyperintensities (WMHs) are associated with vascular risk and Alzheimer’s disease. In this study, we examined relations between WMH load and distribution, amyloid pathology and vascular risk in 339 controls and cases with either subjective (SCD) or mild cognitive impairment (MCI). Regional deep (DWMH) and periventricular (PWMH) WMH loads were determined using an automated algorithm. We stratified on Aβ1-42 pathology (Aβ+/−) and analyzed group differences, as well as associations with Framingham Risk Score for cardiovascular disease (FRS-CVD) and age. Occipital PWMH (p = 0.001) and occipital DWMH (p = 0.003) loads were increased in SCD-Aβ+ compared with Aβ− controls. In MCI-Aβ+ compared with Aβ− controls, there were differences in global WMH (p = 0.003), as well as occipital DWMH (p = 0.001) and temporal DWMH (p = 0.002) loads. FRS-CVD was associated with frontal PWMHs (p = 0.003) and frontal DWMHs (p = 0.005), after adjusting for age. There were associations between global and all regional WMH loads and age. In summary, posterior WMH loads were increased in SCD-Aβ+ and MCI-Aβ+ cases, whereas frontal WMHs were associated with vascular risk. The differences in WMH topography support the use of regional WMH load as an early-stage marker of etiology. 相似文献
99.
Predictors of First‐Line Treatment Success in Children and Adolescents Visiting an Infusion Center for Acute Migraine 下载免费PDF全文
Serena L. Orr MD MSc FRCPC Marielle A. Kabbouche MD Paul S. Horn PhD Hope L. O'Brien MD FAHS FAAN Joanne Kacperski MD Susan LeCates MSN APRN CNP Shannon White DNP CNP Jessica Weberding MSN CNP Mimi N. Miller MSN APRN CNP Scott W. Powers PhD ABPP FAHS Andrew D. Hershey MD PhD FAHS 《Headache》2018,58(8):1194-1202