Intestinal and multivisceral transplantation

Intestinal transplantation is carried out in only a handful of centers in the world. However, patients with such transplantation may be seen at almost any institution and radiologists should be familiar with the expected normal anatomy and complications of intestinal transplantation and its variants. In this paper, we discuss the anatomy and complications following intestinal and multivisceral transplantations. We review the literature and present the findings in a cohort of 46 patients who underwent these procedures at our institution. It is important not to misinterpret the normal adaptation of the transplanted intestine for disease. Some of the complications, including infections, vascular complications, and recurrent tumor, are conclusively diagnosed on imaging studies. Imaging studies may raise the diagnosis of complications such as rejection, graft-versus-host disease, posttransplant lymphoproliferative disease, and sclerosing peritonitis.     

The value of registration correction in the attenuation correction of myocardial SPECT studies using low resolution computed tomography images

BACKGROUND: Artifacts caused by tissue attenuation create problems in the interpretation of myocardial perfusion studies. In a previous study we evaluated attenuation correction using 'Hawkeye' and noted that the incidence of anterior/apical defects increased after attenuation correction. This increased incidence appeared to be associated with mis-registration between emission and transmission images. The main aim of this study was to determine whether correction of mis-registration between emission and transmission scans reduced the incidence of these anterior/apical defects. METHODS: Ninety-four patients (64 men, 30 women) underwent stress/rest myocardial perfusion imaging using (99m)Tc-tetrofosmin (188 studies). Bull's-eye perfusion plots were created using proprietary software (QPS). RESULTS: The marked reduction in defect size, particularly obvious in male patients, in the inferior wall after attenuation correction was not significantly changed by the addition of registration correction. In the anterior and apical walls attenuation correction produced a confusing pattern particularly in females with an overall tendency to increase the defect size. After registration correction fewer anterior/apical defects were created. CONCLUSION: Attenuation correction using 'Hawkeye' reduces the incidence of inferior myocardial perfusion defects but can create anterior and/or apical artifacts. It is essential to evaluate registration carefully in three dimensions before reporting the images. Correction of mis-registration reduces the incidence of anterior/apical defects and can restore the appearance of the anterior/apical area to pre-correction levels.     

Eosinophilic gastroenteritis presenting as acute abdomen

Many causes of acute abdomen are diagnosed on computed tomography (CT). We present two cases of eosinophilic gastroenteritis that showed mural thickening of the stomach, duodenum, and/or proximal jejunum on CT. The correct diagnosis was made by checking the eosinophil count, and, in one case, unnecessary surgery was avoided.     

Analysis of ischemic stroke MR images by means of brain atlases of anatomy and blood supply territories

RATIONALE AND OBJECTIVES: A method for atlas-assisted analysis of stroke magnetic resonance images that is a part of a stroke computer-assisted diagnosis system supporting rapid and quantitative checking of thrombolysis conditions is presented. MATERIALS AND METHODS: Two brain atlases are used for analysis: atlas of anatomy (AA) and atlas of blood supply territories (BSTs). To map these atlases onto scans, two methods are used at present: (1) fast Talairach transformation and (2) midsagittal plane and brain's bounding box matching. After atlas-to-scan mapping, both atlases are superimposed onto the studied images and can be used to get their underlying anatomy and BSTs. To speed up the process of analysis, the system automatically analyzes entire regions occupied by the infarct and penumbra. RESULTS: By using both atlases, the system calculates the following values for each infarct and penumbra region: (1) names of all anatomic structures and BSTs within the region, (2) volumes of occupancy for each structure and territory, and (3) percentages of occupancy for each structure and territory. In addition, the system calculates the infarct-middle cerebral artery (MCA) territory ratio for diffusion-weighted images and the penumbra-MCA territory ratio for perfusion images. Atlas-assisted analysis is fast, and calculations take less than 10 seconds. CONCLUSION: This method potentially facilitates and speeds up stroke data analysis, as well as supports decision making.     

Comparison of 5 methods of QT interval measurements on electrocardiograms from a thorough QT/QTc study: effect on assay sensitivity and categorical outliers

Introduction

We studied moxifloxacin-induced QT prolongation and proportion of categorical QTc outliers when 5 methods of QT measurement were used to analyze electrocardiograms (ECGs) from a thorough QT study.

Methods

QT interval was measured by the threshold, tangent, superimposed median beat, automated global median beat, and longest QT methods in a central ECG laboratory in 2730 digital ECGs from 39 subjects during placebo and moxifloxacin treatment.

Results

All 5 methods were able to demonstrate statistically significant moxifloxacin-induced QTcF prolongation. However, lower bound of 95% 1-sided confidence interval of QTcF prolongation did not exceed 5 milliseconds with the longest QT method. More QTcF outliers were observed with the longest QT and tangent methods, whereas the other 3 methods were comparable. QTcF values greater than 500 milliseconds were observed only with moxifloxacin by the tangent method, and with moxifloxacin and placebo by the longest QT method.

Conclusion

The method of QT measurement must be considered when interpreting individual thorough QT/QTc studies.     

Reader variability in QT measurement due to measurement error and variability in leads selection: A simulation study comparing 2-way vs. 3-way interaction ANOVA model

Reader variability (RV) results from measurement differences or variability in lead used for QT measurements; the latter is not reflected in conventional methods for estimating RV. Mean and SD of QT intervals in 12 leads of 100 ECGs measured twice were used to simulate data sets with inter-RV of 5, 10, 15, 20, and 25 ms and intra-RV of 3, 6, 9, 12, and 15 ms. Six hundred twenty-five data sets were simulated such that different leads were used in Read1 and Read2 in 0, 10%, 20%, 30%, 40% of ECGs by 25 readers. RV was estimated using ANOVA interaction models: three-way model using Reader, ECG and lead as factors, and 2-way model using reader and ECG as factors. Estimates from three-way model accurately matched inter- and intra-RV that were introduced during simulation regardless of percent of ECGs with lead selection variability. The two-way model provides identical estimates when both reads are in same leads, but higher, more realistically estimates when measurements are made in different leads.